University of Vermont

College of Medicine

Department of Pharmacology

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Totman Medical Research Trust


A premier research center on brain blood vessels, the Totman Medical Research Trust supports an interdepartmental, highly interactive research group focused on key aspects of brain artery function from molecules to clinical applications.



Ms. Arlene Howard - Malone, NY

Mr. Donald Stone Jr. - Vienna, VA

Mr. Jeffrey Stone - Waterford, NY


Advisory Board

W. Jonathan Lederer, M.D., Ph.D. Professor and Director, Medical Biotechnology Center, University of Maryland; Visiting Professor, Department of Pharmacology, University of Vermont

Robert W. Hamill, M.D.
Professor, Department of Neurological Sciences

Fredrick C. Morin III, M.D.
Dean, College of Medicine

Brian Cote
Associate Dean for Finance and Administration, College of Medicine




Mark T. Nelson, Ph.D. Professor and Chair, Department of Pharmacology; Professor, Department of Molecular Physiology & Biophysics

George C. Wellman, Ph.D. Professor, Departments of Pharmacologyand Surgery (Division of Neurosurgery)

Joseph E. Brayden, Ph.D. Professor, Department of Pharmacology

Marilyn J. Cipolla, Ph.D. Professor, Departments of Neurology, Obstetrics & Gynecology, and Pharmacology

Wolfgang R. Dostmann, Ph.D. Professor, Departments of Pharmacology and Molecular Physiology & Biophysics

Thomas A. Longden, Ph.D., Research Assistant Professor, Department of Pharmacology

Karen M. Lounsbury, Ph. D. Professor, Department of Pharmacology

Adrian D. Bonev, Ph.D. Research Assistant Professor, Department of Pharmacology

Thomas Heppner, Ph.D. Research Assistant Professor, Department of Pharmacology

David Hill-Eubanks, Ph.D. Research Assistant Professor, Department of Pharmacology

Fabrice Dabertrand, Ph.D. Research Assistant Professor, Department of Pharmacology

Masayo Koide, Ph.D. Research Assistant Professor, Department of Pharmacology

Nathan R. Tykocki, Ph.D. Research Assistant Professor, Department of Pharmacology



Research Technical Support

Jamie Deutsch
Research Technician, Nelson Laboratory

Laurel Haines
Research Technician, Cipolla Laboratory

Maxwell Ross
Research Technician, Nelson Laboratory

Sheila Russell
Researcher/Analyst, Department of Surgery

Jessica Sheehe
Research Technician, Dostmann Laboratory

Sarah Tremble
Research Technician, Cipolla Laboratory

Terry Wellman
Senior Research Technician, Lounsbury and Erdos Laboratories


Post-Doctoral Trainees

Majid Ahmed, MBChB, MRes.
Postdoctoral Associate, Nelson Laboratory

Daniel Collier, Ph.D.
Postdoctoral Associate, Nelson Laboratory

Albert Gonzales, Ph.D.
Postdoctoral Fellow, Nelson Laboratory

Osama Harraz, Ph.D.
Postdoctoral Associate, Nelson Laboratory

Thomas Moon, Ph.D.
Postdoctoral Associate, Dostmann Laboratory

Nuria Villalba Isabel, Ph.D.
Postdoctoral Associate, Wellman/Freeman Laboratories


2015 Totman Lecturer

David Kleinfeld, Ph.D.
Distinguished Professor, Experimental Biophysics Endowed Chair, University of California at San Diego, CA

2014 Totman Lecturer

J. Kevin Foskett, Ph.D.
Professor and Chair, Department of Physiology, University of Pennsylvania, Philadelphia, PA


Mark T. Nelson, Ph.D.

1. *Balbi M, Ghosh M, Longden TA, Jativa Vega M, Gesierich B, Hellal F, Lourbopoulos A, Nelson MT, Plesnila N. Dysfunction of mouse cerebral arteries during early aging. J Cereb Blood Flow Metab. 2015 June 10. PMID: 26058694

2. *Collier DM, Hill-Eubanks DC, Nelson MT. Orchestrating Ca2+ influx through CaV1.2 and CaV3.x channels in human cerebral arteries. J Gen Physiol. 2015 Jun: 145(6): 481-483. PMID: 26009543

3. *Joutel A, Haddad I, Ratelade J, Nelson MT. Perturbations of the cerebrovascular matrisome: a convergent mechanism in small vessel disease of the brain? J Cereb Blood Flow Metab. 2015 Apr 8. PMID: 25853907.

4. *Longden TA, Nelson MT.  Vascular Inward Rectifier K+ Channels as External K+ Sensors in the Control of Cerebral Blood Flow. Microcirculation. 2015 Jan 31. PMID: 25641345

5. *Hill-Eubanks DC, Gonzales AL, Sonkusare SK, Nelson MT.  Vascular TRP Channels: Performing Under Pressure and Going with the Flow. Physiology Review, 2014 Sept: 29(5): 343-360. PMID: 25180264, PMCID: PMC4214829

6. *Mingin GC, Peterson A, Erickson CS, Nelson MT, Vizzard MA. Social stress induces changes in urinary bladder function, bladder NGF content and generalized bladder inflammation in mice. Am J Physiol Regul Integr Comp Physiol.. 2014 Aug 6. PMID: 25100077, PMCID: PMC4187184

7. *Sokusare SK, Dalsgaard T, Bonev AD, Hill-Eubanks DC, Kotlikoff MI, Scott JD, Santana LF, Nelson MT.  AKAP150-dependent vasodilation and is disrupted in hypertension. Science Signaling. 2014 July 8; 7(333): ra66. Journal cover. PMID: 25005230, with Perspective: Pooneh B, Garland CJ. Scaffolding Builds to Reduce Pressure, Science Signaling. 2014 July 8; 7(333) pe 16.

8. *Nausch B, Rode F, Jorgensen S, Nardi A, Korsgaard MP, Hougaard C, Brown WD, Bonev AD, Dyhring T, Strobeak D, Olesen SP, Christophersen P, Grunnet M, Nelson MT, Ronn LC. NS19504 A Novel BK channel activator with relaxing effect on bladder smooth muscle spontaneous phasic contractions. J Pharmacology Exp Ther. 2014 Sep: 350(3): 520-530. PMID: 24951278, PMCID: PMC4152884

9. *Gonzales AL, Yang Y, Sullivan MN, Sanders L, Dabertrand F, Hill-Eubanks DC, Nelson MT, Earley S. A PLC γ1-Dependent, Force-Sensitive Signaling Network in the Myogenic Constriction of Cerebral Arteries. Science Signaling. 2014 May 27; 7(327): ra49. PMID: 24866019, PMCID: PMC4170587

George C. Wellman, Ph.D.

1. *Pappas AC, Koide M, Wellman GC. Astrocyte calcium signaling drives inversion of neurovascular coupling after subarachnoid hemorrhage. (Under revsion for the Journal of Neuroscience.)

2. *Balbi, Koide M, Schwarzmaier S, Wellman GC, Plesnila N. Acute changes in neurovascular reactivity after subarachnoid hemorrhage in vivo. (Revised manuscript submitted to J Cereb Blood Flow Metab.)

3. *Pappas A, Wellman GC. Setting the pace for GI motility: ryanodine receptors and IP3 receptors within interstitial cells of Cajal. Focus on "Intracellular Ca2+ release from endoplasmic reticulum regulates slow wave currents and pacemaker activity of interstitial cells of Cajal". Am J Physiol Cell Physiol. 2015 April 15; 308(8): C606-607. PMID: 25696810, PMCID: PMC4398849

4. *Koide M., Wellman GC. SAH-induced MMP activation and K V current suppression is mediated via both ROS-dependent and ROS-independent mechanisms. Acta Neurochir Supply. 2015: 120: 89-94. PMID: 25366605

5. *Koide M, Wellman GC. Activation of TRPV4 channels does not mediate inversion of neurovascular coupling after SAH. Acta Neurochir Supply. 2015: 120:111-116. PMID: 25366609

6. *Koide M, Syed AU, Braas KM, May V, Wellman GC. Pituitary adenylate cyclase activating polypeptide (PACAP) dilates cerebellar arteries through activation of large-conductance Ca2+ - activated (BK) and ATP-sensitive (KATP) K+ channels. J Mol Neurosci. 2014 Nov: 54(3): 443-450. PMID: 24744252

7. *Neill LA, Saundry CM, Hyman HN, Wellman GC. Evidence against a systemic arterial defect in patients with inflammatory bowel disease. J Surg Res. 2014 Oct; 191(2): 318-322. PMID: 24819742


Joseph E. Brayden, Ph.D.

1. *Earley S, Brayden J. Transient Receptor Potential channels in the vasculature. Physiol Rev. 2015 Apr; 95(2): 645-690, PMID: 25834234

2. *Dabertrand F, Kroigaard C, Bonev AD, Cognat E, Dalsgaard T, Domenga-Denier V, Hill-Eubanks DC, Brayden J, Joutel A, Nelson MT. Potassium channelopathy-like defect unerlies early-stage cerebrovascular dysfunction in a genetic model of small vessel disease. Proc Natl Acad Sci, USA. 2015 Feb 2. pii: 201420765 PMID: 25646445, PMCID: PMC4343103

3. *Syed A, Koide M, Brayden J, Wellman G. Regulation of middle menigeal artery diameter by ATP-sensitive potassium channels. FASEB Journal. 2015 Apr. 29: 943-945.

4. *Li Y, Brayden JE. Rho kinase regulates myogenic depolarization of cerebral parenchymal arterioles. FASEB Journal. 2015 Apr. 29: 780-789.

5. *Li Y, Baylie RL, Tavares MJ, Brayden JE. TRPM4 channels couple purinergic receptor mechanoactivation and myogenic tone development in cerebral parenchymal arterioles. J Cerebr Blood Flow Metab. 2014 Oct: 34(10): 1706-1714. PMID: 25099756, PMCID: PMC4269733


Marilyn J. Cipolla, Ph.D.

1. *Wallace K, Tremble SM, Owens MY, Morris R, Cipolla MJ. Plasma From Patients With HELLP Syndrome Increases Blood-Brain Barrier Permeability. Reprod Sci. 2015 Mar; 22(3): 278-284., PMID: 25194151, PMCID: PMC4352144

2. *Johnson AC, Tremble SM, Chan SL, Moseley J, LaMarca B, Nagle KJ, Cipolla MJ. Magnesium sulfate treatment reverses seizure susceptibility and decreases neuroinflammation in a rat model of severe preeclampsia. PLoS One. 2014 Nov 19; 9(11): e113670. PMID: 25409522, PMCID: PMC4237502

3. *Cipolla MJ, Chan SL, Sweet J, Tavares MJ, Gokina N and Brayden JE. Postischemic reperfusion causes smooth muscle calcium sensitization and vasoconstriction of parenchymal arterioles. Stroke. 2014 Aug; 45(8): 2425-2430. PMID: 24968928, PMCID: PMC4144269

Invited Reviews:

1. *Johnson AC, Cipolla MJ. (2015): The cerebral circulation during pregnancy: Adapting to maintain normalcy. Physiology 30(2): 139-147.


Wolfgang R. Dostmann, Ph.D.

1. *Lee DI, Zhu G, Saski T, Cho GS, Hamdani N, Holewinski R, Jo SH, Danner T, Zhang M, Rainer PP, Bedja D, Kirk JA, Ranek MJ, Dostmann WR, Kwon C, Margulies KB, Van Eyk JE, Paulus WJ, Takimoto E, Kass DA. Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease. Nature. 2015 Mar 26; 519(7544): 472-476. PMID: 25799991, PMCID: PMC4376609

Karen M. Lounsbury, Ph.D.

1. *Wo P, Wellman TF, Howe AK, Francklyn CS, Lounsbury KM. Non-canonical activity of threonyl-tRNA synthetase promotes angiogenesis and invasion in a mouse model of ovarian cancer. (In preparation, 2015.)

2. *Mirando AC, Fang P, Williams TF, Baldor LC, Howe AK, Ebert AM, Wilkinson B, Lounsbury KM, Guo M, Francklyn CS.  Molecular mechanism of tRNA syntetase angiogenesis function revealed by a bioenineered macrolide inhibitor. (Revision submitted to Nat. Sci. Rpts 2015.)

3. *Wellman TF, Williams TF, Wong C, Rincon M, Ashikaga T, Mount SL, Francklyn CS, Lounsbury KM.  Threonyl-tRNA synthetase overexpression correlates with angiogenesis and progression of human ovarian cancer. BMC Cancer. 2014 Aug 27; 14:620. PMID: 25163878, PMCID: PMC4155084

4. *Mirando AC, Francklyn CS, Lounsbury KM. Regulation of Angiogenesis by AminoacyltRNA Synthetases. Int J of Mol Sci. 2014 Dec. 19; 15: 23725-23748. Review. ISSN 1422-0067


Kalev Freeman, M.D.

1. *Mann KG, Freeman K. TACTIC: Trans-Agency Consortium for Trauma-Induced Coagulopathy, J Thromb and Haemostatis. 2015 Jun. 13(Suppl. 1): S63-S71.

2. *Wylie GR, Freeman K, Thomas A, Shpaner M, OKeefe M, Watts R, Naylor MR. Cognitive Improvement after Mild Traumatic Brain Injury Measured with Functional Neuroimaging during the Acute Period. PLoS One. 2015 May 11: 10(5): e0126110.2015. PMID: 25962067, PMCID: PMC4427352

3: *Villalba N, Sonkusare SK, Longden TA, Tran TL, Nelson MT, Wellman GC, Freeman K. Traumatic brain injury disrupts cerebrovascular tone through endothielial inducible nitric oxide synthase expression and nitric oxide gain of function. J AM Heart Assoc, 2014 Dec 19; 3(6), pii: e001474. PMID: 25527626 

4: *Watts R, Thomas A, Filippi CG, Nickerson JP, Freeman K. Potholes and molehills: Bias in diagnostic performace of diffusion-tensor imaging in concussion. Radiology. 2014, July. PMID: 24635677, PMCID: PMC4263643

*Totman Medical Research Fund Acknowledged

Last modified June 10 2016 09:06 AM