University of Vermont

College of Medicine

Department of Pharmacology

Bio for Benedek Erdos
Benedek Erdos

Benedek Erdos


Contact Information
E-mail: Benedek.Erdos@uvm.edu
Phone:
802-656-0988
Office Location:
89 Beaumont Ave, Given E315A, Burlington, VT 05405

Education

1999-2004  Ph.D.  Semmelweis University, School of Medicine, Budapest, Hungary
1993-1999  M.D.   Semmelweis University, School of Medicine, Budapest, Hungary

Professional Positions

2014-Present  Assistant Professor, Department of Pharmacology, University of Vermont

2011-2014  Research Assistant Professor, Department of Physiology and Functional Genomics, University of Florida, College of Medicine, Gainesville, FL
2008-2011  Research Assistant Professor, Department of Pharmacology and Therapeutics, University of Florida, College of Medicine, Gainesville, FL
2006-2008  Assistant Instructor, Department of Pharmacology and Therapeutics, University of Florida, College of Medicine, Gainesville, FL
2005-2011  Research Coordinator,  Hypertension and Aging Laboratory, Malcom Randall VA Medical Center, Gainesville, FL
2004-2006  Postdoctoral Associate, Department of Pharmacology and Therapeutics, University of Florida, College of Medicine, Gainesville, FL
2001-2004  Postdoctoral Associate, Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston-Salem, NC
1994-2001  Research Assistance, Institute of Human Physiology and Clinical Experimental Research, Semmelweis University, Budapest, Hungary

Research Grants

American Heart Association, 7/1/2011 - 6/30/2015, Scientist Development Grant  "Hydrogen peroxide and age-related sympathetic nervous system dysregulation"
American Federation for Aging Research,  07/1/2011 - 06/30/2013, "Hydrogen peroxide and age-related sympathetic nervous system dysregulation", pursuing one aim: to determine whether caloric restriction prevents age-related sympathetic nervous system dysregulation by maintaining adequate catalase expression, low hydrogen peroxide levels and normal catecholaminergic neurotransmission in the hypothalamus and brainstem.

Presentations

2012  Invited Speaker  Burnett School of Biomedical Sciences, University of Central Florida
2012  Invited Speaker  Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida
2012  Invited Speaker  Department of Physiological Sciences, College of Veterinary Medicine, University of Florida
2010  Invited Speaker  Department of Food Science and Human Nutrition, University of Florida
2010  Invited Speaker  Geriatric Research, Education, and Clinical Center at Gainesville, FL
2009  Invited Speaker  Department of Physiology and Functional Genomics, University of Florida, Gainesville, FL
2007  Invited Speaker  Department of Physiology, Medical College of Georgia, Augusta, GA
2007  Invited Speaker  Institute on Aging and GRECC seminar series,  University of Florida, Gainesville, FL
2006  Invited Speaker  Microcirculatory Society, Young Investigator Symposium, Experimental Biology, San Francisco, CA

Professional Activities

Professional Memberships:
    American Journal of Physiology Society
    American Heart Association
Journal Referee:
    American Journal of Physiology - Heart and Circulatory Physiology
    British Journal of Pharmacology
    Circulation
    Diabetes
    Experimental Physiology
    Frontiers in Physiology
    International Journal of Developmental Neuroscience
    Journal of the Renin-Angiotensin-Aldosterone System
    Kidney International
    Letters in Drug Design & Discovery
Grant Study Section:
    American Heart Association - Greater Southeast Affiliate, Vascular Biology & Blood Pressure Study
    Group (2009 - present)

Publications (Peer Reviewed)

For a complete listing of publications go to PubMed.

2013  Tumer N, Svetlov S, Whidden M, Kirichenko N, Prima V, Erdos B, Sherman A, Kobeissy F, Yezierski R, Scarpace PJ, Vierck C, Wang KK.  "Overpressure blast-wave induced brain injury elevates oxidative stress in the hypothalamus and catecholamine biosynthesis in the rat adrenal medulla"  Neurosci Lett.  2013 Jun 7; 544:  62-67  PMID:  23570732

2012  Daubert DL, McCowan M, Erdos B, Scheuer DA.  "Nucleus of the solitary tract catecholaminergic neurons modulate the cardiovascular response to psychological stress in rats"  J Physiol.  2012 Oct 1;  590(Pt 19):  4881-4895   PMID:  22753543

2012  Erdos B, Kirichenko N, Whidden M, Basgut B, Woods M, Cudykier I, Tawil R, Scarpace PJ, Tumer N.  "Effect of age on high-fat diet-induced hypertension"  Am J Physiol Heart Circ Physiol.  2011 Jul: 301(1):  H164-H172  PMID:  21551274

2011  Whidden MA, Kirichenko N, Halici Z, Erdos B, Foster TC, Tumer N.  "Lifelong caloric restriction prevents age-induced oxidative stress in the sympathoadrenal system of Fischer 344 x Brown Norway rats"  Biochem Biophys Res Commun.  2011 May 13; 408(3):  454-458  PMID:  2152745

2010  Zang Y, Rodrigues E, Gao YX, King M, Cheng KY, Erdos B, Gumer N, Carter C, Scarpace PG.  "Pro-opiomelanocortin gene transfer to the nucleus of the solitary track but not arcuate nucleus ameliorates chronic diet-induced obesity"  Neuroscience.  2010 Sep 15: 169(4):  1662-1671.  PMID:  20538045

2010  Erdos B, Cudykier I, Woods M, Basgut B, Whidden M, Tawil R, Cardounel AJ, Tumer N.  "Hypertensive effects of central angiotensin II infusion and restraint stress are reduced with age"  J Hyperten.  2010 Jun; 28(6):  1298-1306  PMID:  20308921

2009  Erdos B, Broxson CS, Cudykier I, Basgut B, Whidden M, Landa T, Scarpace PJ, Tumer N.  "Effect of high-fat diet feeding on hypothalamic redox signaling and central blood pressure regulation"  Hypertens Res.  2009 Nov; 32(11):  983-988  PMID:  19713964

2009  Manfredsson FP, Tumer N, Erdos B, Landa T, Broxson CS, Sullivan LF, Rising AC, Foust KD, Zhang Y, Muzyczka N, Gorbatyuk OS, Scarpase PJ, Mandel RJ.  "Nigrostraital rAAV-mediated GDNK overexpression induces robust weight loss in a rat model of age-related obesity"  Mol Ther.  2009 Jun; 17(6):  980-991  PMID:  19277011

2008  Erdos B, Erdem SR, Erdem A, Broxson CS, Tumer N.  "Effect of age on angiotensin II-mediated downregulation of adrenomedullary catecholamine biosynthetic enzymes"  Exp Gerontol.  2008 Aug; 43(8):  806-809  PMID:  1822866

2007  Tumer N, Erdos B, Matheny M, Cudykier I, Scarpace PJ.  "Leptin antagonist reverses hypertension caused by leptin overexpression, but fails to normalize obesity-related hypertension"  J Hypertens.  2007 Dec; 25(12):  2471-2478  PMID:  17984669

2007  Erdos B, Broxson CS, Landa T, Scarpace PJ, Leeuwenburgh C, Zhang Y, Tumer N.  "Effects of life-long caloric restriction and voluntary exercise on age-related changes in levels of catecholamine biosynthetic enzymes and angiotensin II receptors in the rat adrenal medulla and hypothalamus"  Exp Gerontol.  2007 Aug; 42(8):  745-752  PMID:  17540525

2007  Mersich T, Szelke E, Erdos B, Lacza Z, Komjati K, Sandor P.  "Somatosensory pain does not affect total cerebral blood volume"  Neuroreport.  2007 May 7; 18(7):  649-652  PMID:  17426592

2006  Busija DW, Miller AW, Katakam P, Erdos B.  "Adverse effects of reactive oxygen species on vascular reactivity in insulin resistance"  Antioxid Redox Signal.  2006 Jul-Aug; 8(7-8):  1131-1140  PMID:  16910761

2006  Erdos B, Broxson CS, King MA, Scarpace PJ, Tumer N.  "Acute pressor effect of central angiotensin II is mediated by NAD(P)H-oxidase-dependent production of superoxide in the hypothalamic cardiovascular regulator nuclei"  J Hypertens.  2006 Jan; 24(1):  109-116  PMID:  16331108

2006  Erdos B, Snipes JA, Tulbert CD, Katakam P, Miller AW, Busija DW.  "Rosuvastatin improves cerebrovascular function in Zucker obese rats by inhibiting NAD(P)H oxidase-dependent superoxide production"  Am J Physiol Heart Circ Physiol.  2006 Mar; 290(3):  H1264-H1270  PMID:  16284235

2005  Krizbai IA, Lenzser G, Szatmari E, Farkas AE, Wilhelm I, Fekete Z, Erdos B, Bauer H, Bauer HC, Sandor P, Komjati K.  "Blood-brain barrier changes during compensated and decompensated hemorrhagic shock"  Shock.  2005 Nov; 24(5):  428-433  PMID:  16247328

2005  Busija DW, Miller AW, Katakam P, Erdos B.  "Insulin resistance and associated dysfunction of resistance vessels and arterial hypertension"  Minerva Med.  2005 Aug; 96(4):  223-232  PMID:  16179890

2005  Simandle SA, Erdos B, Snipes JA, Miller AW, Busija DW.  "Insulin resistance does not impair contractile responses of cerebral arteries"  Life Sci.  2005 Sep 16; 77(18):  2262-2272  PMID:  15958270
2005  Katakam PV, Tulbert CD, Snipes JA, Erdos B, Miller AW, Busija DW.  "Impaired insulin-induced vasodilation in small coronary arteries of Zucker obese rats is mediated by reactive oxygen species"  Am J Physiol Heart Circ Physiol.  2005 Feb; 228(2):  H854-H860  PMID:  15650157