University of Vermont

College of Medicine

Department of Pharmacology

Bio for Benedek Erdos
Benedek Erdos

Benedek Erdos


Contact Information
E-mail: Benedek.Erdos@uvm.edu
Phone:
802-656-0988
Office Location:
89 Beaumont Ave, Given E315A, Burlington, VT 05405

Education

1999-2004  Ph.D.  Semmelweis University, School of Medicine, Budapest, Hungary
1993-1999  M.D.   Semmelweis University, School of Medicine, Budapest, Hungary

Professional Positions

2014-Present  Assistant Professor, Department of Pharmacology, University of Vermont

2011-2014  Research Assistant Professor, Department of Physiology and Functional Genomics, University of Florida, College of Medicine, Gainesville, FL
2008-2011  Research Assistant Professor, Department of Pharmacology and Therapeutics, University of Florida, College of Medicine, Gainesville, FL
2006-2008  Assistant Instructor, Department of Pharmacology and Therapeutics, University of Florida, College of Medicine, Gainesville, FL
2005-2011  Research Coordinator,  Hypertension and Aging Laboratory, Malcom Randall VA Medical Center, Gainesville, FL
2004-2006  Postdoctoral Associate, Department of Pharmacology and Therapeutics, University of Florida, College of Medicine, Gainesville, FL
2001-2004  Postdoctoral Associate, Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston-Salem, NC
1994-2001  Research Assistance, Institute of Human Physiology and Clinical Experimental Research, Semmelweis University, Budapest, Hungary

Research Grants

American Heart Association, 7/1/2011 - 6/30/2015, Scientist Development Grant  "Hydrogen peroxide and age-related sympathetic nervous system dysregulation"
American Federation for Aging Research,  07/1/2011 - 06/30/2013, "Hydrogen peroxide and age-related sympathetic nervous system dysregulation", pursuing one aim: to determine whether caloric restriction prevents age-related sympathetic nervous system dysregulation by maintaining adequate catalase expression, low hydrogen peroxide levels and normal catecholaminergic neurotransmission in the hypothalamus and brainstem.

Presentations

2012  Invited Speaker  Burnett School of Biomedical Sciences, University of Central Florida
2012  Invited Speaker  Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida
2012  Invited Speaker  Department of Physiological Sciences, College of Veterinary Medicine, University of Florida
2010  Invited Speaker  Department of Food Science and Human Nutrition, University of Florida
2010  Invited Speaker  Geriatric Research, Education, and Clinical Center at Gainesville, FL
2009  Invited Speaker  Department of Physiology and Functional Genomics, University of Florida, Gainesville, FL
2007  Invited Speaker  Department of Physiology, Medical College of Georgia, Augusta, GA
2007  Invited Speaker  Institute on Aging and GRECC seminar series,  University of Florida, Gainesville, FL
2006  Invited Speaker  Microcirculatory Society, Young Investigator Symposium, Experimental Biology, San Francisco, CA

Professional Activities

Professional Memberships:
    American Journal of Physiology Society
    American Heart Association
Journal Referee:
    American Journal of Physiology - Heart and Circulatory Physiology
    British Journal of Pharmacology
    Circulation
    Diabetes
    Experimental Physiology
    Frontiers in Physiology
    International Journal of Developmental Neuroscience
    Journal of the Renin-Angiotensin-Aldosterone System
    Kidney International
    Letters in Drug Design & Discovery
Grant Study Section:
    American Heart Association - Greater Southeast Affiliate, Vascular Biology & Blood Pressure Study
    Group (2009 - present)

Publications (Peer Reviewed)

For a complete listing of publications go to PubMed.

2015  Erdos B, Clifton RR, Liu M, Li H, McCowan ML, Sumners C, Scheuer DA.  Novel mechanism within the paraventricular nucleus reduces both blood pressure and hypothalamic pituitary-adrenal axis responses to acute stress.  Am J Physiol Heart Circ Physiol.  doi: 10.1152/ajpheart.00207.2015.  PMID:  26071542

2015  Erdos B, Backes I, McGowan ML, Hayward LF, Scheuer DA.  Brain-derived neurotrophic factor modulates angiotensin signaling in the hypothalamus to increase blood pressure in rats.  Am J Physiol Heart Circ Physiol.  doi:  10.1152/ajpheart.00776.2014.  PMID:  25576628, PMCID:  PMC4360054

2013  Tumer N, Svetlov S, Whidden M, Kirichenko N, Prima V, Erdos B, Sherman A, Kobeissy F, Yezierski R, Scarpace PJ, Vierck C, Wang KK.  "Overpressure blast-wave induced brain injury elevates oxidative stress in the hypothalamus and catecholamine biosynthesis in the rat adrenal medulla"  Neurosci Lett.  doi:  10.1016/j.neulet.2013.03.042.  PMID:  23570732

2012  Daubert DL, McCowan M, Erdos B, Scheuer DA.  "Nucleus of the solitary tract catecholaminergic neurons modulate the cardiovascular response to psychological stress in rats"  J Physiol.  doi:  10.1113/jphysiol.2012.23231.  PMID:  22753543, PMCID:  PMC3487043

2012  Erdos B, Kirichenko N, Whidden M, Basgut B, Woods M, Cudykier I, Tawil R, Scarpace PJ, Tumer N.  "Effect of age on high-fat diet-induced hypertension"  Am J Physiol Heart Circ Physiol.  doi:  10.1152/ajpheart.01289.2010.  PMID:  21551274

2011  Whidden MA, Kirichenko N, Halici Z, Erdos B, Foster TC, Tumer N.  "Lifelong caloric restriction prevents age-induced oxidative stress in the sympathoadrenal system of Fischer 344 x Brown Norway rats"  Biochem Biophys Res Commun.  doi:  10.1016/j.bbrc.2011.04.051.  PMID:  2152745, PMCID:  PMC3098886

2010  Zang Y, Rodrigues E, Gao YX, King M, Cheng KY, Erdos B, Gumer N, Carter C, Scarpace PG.  "Pro-opiomelanocortin gene transfer to the nucleus of the solitary track but not arcuate nucleus ameliorates chronic diet-induced obesity"  Neuroscience.  2010 Sep 15: 169(4):  1662-1671.  PMID:  20538045

2010  Erdos B, Cudykier I, Woods M, Basgut B, Whidden M, Tawil R, Cardounel AJ, Tumer N.  "Hypertensive effects of central angiotensin II infusion and restraint stress are reduced with age"  J Hyperten.  doi:  10.1097/HJH.0b013e328338a075.  PMID:  20308921

2009  Erdos B, Broxson CS, Cudykier I, Basgut B, Whidden M, Landa T, Scarpace PJ, Tumer N.  "Effect of high-fat diet feeding on hypothalamic redox signaling and central blood pressure regulation"  Hypertens Res.  doi:  10.1038/hr.2009.129.  PMID:  19713964

2009  Manfredsson FP, Tumer N, Erdos B, Landa T, Broxson CS, Sullivan LF, Rising AC, Foust KD, Zhang Y, Muzyczka N, Gorbatyuk OS, Scarpase PJ, Mandel RJ.  "Nigrostraital rAAV-mediated GDNK overexpression induces robust weight loss in a rat model of age-related obesity"  Mol Ther.  doi:  10.1038/mt.2009.45.  PMID:  19277011

2008  Erdos B, Erdem SR, Erdem A, Broxson CS, Tumer N.  "Effect of age on angiotensin II-mediated downregulation of adrenomedullary catecholamine biosynthetic enzymes"  Exp Gerontol.  doi:  10.1016/j.exger.2008.04.012.  PMID:  1822866

2007  Tumer N, Erdos B, Matheny M, Cudykier I, Scarpace PJ.  "Leptin antagonist reverses hypertension caused by leptin overexpression, but fails to normalize obesity-related hypertension"  J Hypertens.  PMID:  17984669

2007  Erdos B, Broxson CS, Landa T, Scarpace PJ, Leeuwenburgh C, Zhang Y, Tumer N.  "Effects of life-long caloric restriction and voluntary exercise on age-related changes in levels of catecholamine biosynthetic enzymes and angiotensin II receptors in the rat adrenal medulla and hypothalamus"  Exp Gerontol.  doi:  10.1016/j.exger.2007.04.007.  PMID:  17540525, PMCID:  PMC2034493

2007  Mersich T, Szelke E, Erdos B, Lacza Z, Komjati K, Sandor P.  "Somatosensory pain does not affect total cerebral blood volume"  Neuroreport.  PMID:  17426592