1980-1983 Easton Area High School, Easton, PA
1983-1987 B.S. Biochemistry; The Pennsylvania State University, University Park, PAResearch Mentor: Dr. Richard Bernlohr, Ph.D.1987-1993 Ph.D. Pharmacology; Department of PharmacologyThe University of Pennsylvania, Philadelphia, PADissertation Advisor: Dr. David Manning, Ph.D.
1993-1996 Post-doctoral Fellow; Department of Pathology and Vermont Cancer Center, The niversity of Vermont, Burlington, VT. Supervisor: Dr. Ian Macara, Ph.D.1996-1997 Post-doctoral Associate; Department of PharmacologyThe University of Vermont, Burlington, VTSupervisor: Dr. Mark Nelson, Ph.D. and Dr. Joseph Brayden, Ph.D.
Signal Transduction in Vascular Remodeling: Signaling through transcription factors during normal or pathological cell growth; tumor angiogenesis; hypertension and atherosclerosis; regulation by calcium, growth factors and hypoxia/ischemia; control of timed cell division; nuclear transport kinetics; subcellular imaging of signaling molecules; manipulation of recombinant protein structure/function.
1999 - Present Cell and Molecular Biology Faculty; University of Vermont, Burlington, VT
1998 - Present Member Vermont Cancer Center; University of Vermont, Burlington, VT1998 - 2004 Assistant Professor of Pharmacology, University of Vermont, Burlington, VT
2010 - Present Professor of Pharmacology, University of Vermont, Burlington, VT2004 - 2010 Associate Professor of Pharmacology, University of Vermont, Burlington, VT
For a complete list of Karen M. Lounsbury's publications, please visit PubMed.2014 Shao Y, Wellman TL, Lounsbury KM, Zhao FQ. Differential regulation of GLUT1 and GLUT8 expression by hypoxia in mammary epithelial cells. Am J Physiol Regul Integr Comp Physiol. 2014 Aug 1: 307(3): R237-247. doi: 10.1152/ajpregu.00093.2014. PMID: 24920730
2013 Williams TF, Mirando AC, Wilkinson B, Francklyn CS, Lounsbury KM. Secreted Threonyl-tRNA synthetase stimulates endothelial cell migration and angiogenesis. Sci Rep. 2013; 3:1317. doi: 10.1038/srep01317. PMID: 23425968, PMCID: PMC3578223
2011 Cassavaugh JM, Hale SA, Wellman TL, Howe AK, Wong C, Lounsbury KM. Negative Regulation of HIF-1alpha by an FBW7-mediated degradation pathway during hypoxia. J Cell Biochem. 2011 Dec; 112(12): 3882-3890. doi: 10.1002/jcb.23321. PMID: 21964756, PMCID: PMC3202039
2011 Olson N, Hristova M, Heintz NH, Lounsbury KM, van der Vliet A. Activation of hypoxia-inducible factor-1 protects airway epithelium against oxidant-induced barrier dysfunction. Am J Physiol Lung Cell Mol Physiol. 2011 Dec; 301(6): L993-L1002. doi: 10.1152/ajplung.00250.2011. PMID: 21926263, PMCID: PMC3233830
2011 Cassavaugh J, Lounsbury KM. Hypoxia-mediated biological control. J Cell Biochem. 2011 Mar; 112(3): 735-744. doi: 10.1002/jcb.22956. PMID: 21328446
2009 Buder-Hoffmann SA, Shukla A, Barrett TF, Macpherson MB, Lounsbury KM, Mossman BT. A Protein Kinase Cdelta-Dependent Protein Kinase D Pathway Modulates ERK1/2 and JNK1/2 Phosphorylation and Bim-Associated Apoptosis by Asbestos. Am. J. Pathol. 2009 Feb; 174(2): 449-459. doi: 10.2353ajath.2009.080180. PMID: 19116364, PMCID: PMC2630554
2008 Bove PF, Hristova M, Wesley UV, Olson N, Lounsbury KM, van der Vliet A. Inflammatory levels of nitric oxide inhibit airway epithelial cell migration by inhibition of the kinase ERK1/2 and activation of hypoxia-inducible factor-1alpha. J Biol Chem. 2008 Jun 27; 283(26): 17919-17928. doi: 10.1074/jbc.M709914200. PMID: 18424783, PMCID: PMC24406002008 Barlow, CA, Kitiphongspattana, K, Siddiqui, N, Roe, MW, Mossman, BT, and Lounsbury, KM. Protein kinase A-mediated CREB phosphorylation is an oxidant-induced survival pathway in alveolar type II cells. Apoptosis, 13:681-92, 2008.
2008 Lounsbury KM. Preventing stenosis by local inhibition of KCa3.1: a finger on the phenotypic switch. Arterioscler Thromb Vasc Biol. 2008 Jun; 28(6): 1036-8. doi: 10.1161/ATVBAHA.108.164988. PMID: 18495973