University of Vermont

College of Medicine

Department of Pharmacology

Bio for Wolfgang Dostmann, Ph.D.
Wolfgang Dostmann, Ph.D.

Wolfgang Dostmann, Ph.D.

Professor
Department of Pharmacology


Contact Information
E-mail: wdostman@uvm.edu
Phone:
(802)656-0223
Office Location:
Given B333

Website

Lab

Education

1976 Abitur, Gymnasium 'Kurt-Schumacher-Allee', Bremen, Germany

1976-1983 University of Bremen, Germany. Department of Chemistry:

1983 Dipl. Chem. (M.S.), Institute of Organic Chemistry, University of Bremen, Germany.

1987 Dr. rer. nat. (Ph.D.), Institute of Organic Chemistry, University of Bremen, Germany.

1996 Dr. med. habil. (Habilitation), Institute of Pharmacology & Toxicology, Technical University of Munich, Germany.

Academic Appointments

2009 - Present Professor (tenure), Department of Pharmacology, University of Vermont, College of Medicine,

2004 – 2009 Associate Professor (tenure), Department of Pharmacology, University of Vermont, College of Medicine,

1998 - 2004 Assistant Professor, Department of Pharmacology, University of Vermont, College of Medicine,

1997 - 1998 Privatdozent (Senior Lecturer), Institute of Pharmacology and Toxicology, Faculty of Medicine, Technical University of Munich, Germany

1991 - 1997 Assistant (Lecturer), Institute of Pharmacology and Toxicology, Technical University of Munich, Germany

1989 - 1991 Research Associate, University of California at San Diego, California

1987 - 1989 Post-Doctoral Fellow, University of California at San Diego, California

1983 - 1987 Graduate Student and Teaching Assistant, University of Bremen, Institute of Organic Chemistry, Bremen, Germany

Research Grants

1998 - 2018 Research Grant, R37 DK053832, Co-investigator (PI: Mark T. Nelson). National Institute of Health, NIH/NIDDK. Ca2+ sparks and urinary bladder smooth muscle excitability. $215,000

2008 - 2013 Research Grant, R01 HL68991-02. Principal Investigator. National Institute of Health, NIH/NHLBI. Title: Exploring vasomotor mechanism using new PKG inhibitors and cGMP biosensors. $250,000

2010 - 2012 Internal Research Grant (IGP), College of Medicine, UVM. Title: The crystal structure of cGMP-dependent protein kinase

2008 - 2012 Research Grant, R01 HL085646-01, Co-investigator (PI: Albert van der Vliet). National Institute of Health, NIH/NHLBI. Title: Dual Oxidase in Airway Epithelial Repair and Remodeling. $250,000

2001 - 2012 Research Grant, R01 DK56644, Co-investigator (PI: Steven Lidofsky). National Institute of Health, NIH/NIDDK. Title: Mechanisms of cell volume regulation in liver. $212,500

2006 - 2011 Research Grant BayerHealthcare, Germany. Principal Invesigator. Title: Characterization of PKG Activators and Crystallization of PKG and Co-Crystallisation with PKG Activators. $50,000

2007 - 2009 Research Grant BayerHealthcare, Germany. Principal Investigator. Title: Analyzing the redox equilibrium of soluble guanylyl cyclase in vascular smooth muscle using BAY 58-2667 and cGMP biosensors. $37,000

Awards and Honors

1998 Lead-User Award (Surface Plasmon Resonance), BioTul Inc, Munich, Germany

1997 Venia legendi, (Privatdozent), Munich/Bavaria, Germany

1987 Doctor Graduation with honors, summa cum laude, Bremen, Germany

1985 Research Award, Sandoz Inc., East Hanover, New Jersey
1983 Masters Graduation with honors, magna cum laude, Bremen, Germany

Publications (Peer Reviewed)

2010 Batchelor AM, Bartus K, Reynell C, Constantinou S, Halvey EJ, Held KF, Dostmann WR, Vernon J, Garthwaite J. Exquisite sensitivity to subsecond, picomolar nitric oxide transients conferred on cells by guanylyl cyclase-coupled receptors. Proc Natl Acad Sci USA, in press, 2010.

2010 Lavogina D, Nickl CK, Enkvist E, Raidaru G, Lust M, Vaasa A, Uri A, Dostmann WR. Adenosine analogue-oligo-arginine conjugates (ARCs) serve as high-affinity inhibitors and fluorescence probes of type I cGMP-dependent protein kinase (PKGIalpha). Biochim Biophys Acta. 1804:1857-1868, 2010.

2010 Nickl CK, Raidas SK, Zhao H, Sausbier M, Ruth P, Tegge W, Brayden JE, and Dostmann WR, (D)-amino acid analogues of DT-2 as highly selective and superior inhibitors of cGMP-dependent protein kinase Ia. Biochim Biophys Acta, 1804:524-32, 2010.

2009 Steiner JA, Carneiro AM, Wright J, Matthies HJ, Prasad HC, Nicki CK, Dostmann WR, Buchanan CC, Corbin JD, Francis SH, Blakely RD. cGMP-dependent protein kinase Ialpha associates with the antidepressant-sensitive serotonin transporter and dictates rapid modulation of serotonin uptake. Mol Brain, 5;2(1):26, 20093

2009 Pinkse MW, Rijkers DT, Dostmann WR, Heck AJ. Mode of Action of cGMP-dependent Protein Kinase-specific Inhibitors Probed by Photoaffinity Cross-linking Mass Spectrometry. J Biol Chem, 284:16354-16368, 2009.

For a complete list of Wolfgang Dostmann's publications, please visit PubMed.