University of Vermont

College of Medicine

Department of Pharmacology

Bio for Joseph E. Brayden, Ph.D.
Joseph E. Brayden, Ph.D.

Joseph E. Brayden, Ph.D.

Department of Pharmacology

Contact Information
Office Location:
Given B303




1973 B.S. (Biology) - Union College, Schenectady, N.Y.

1982 Ph.D. (Physiology & Biophysics) - University of Vermont, College of Medicine

Awards and Honors

1968 National Science Foundation Summer Fellowship, Brown University

1969 - 1973 New York State Regents Scholarship

1969 - 1973 Clark Foundation Scholarship (full undergraduate tuition and fees)

1973 Cum Laude graduate, Union College

1983 - 1985 PHS NRSA Postdoctoral Fellowship

1986 - 1989 PHS NIH New Investigator Award

1990 - 1995 Established Investigator of the American Heart Association

1992 - 1996 Member of the Experimental Cardiovascular Sciences study section (Division of Research Grants, NIH)


For a complete list of Joseph E. Brayden's publications, please visit PubMed

2014  Li Y, Baylie RL, Tavares MJ, Brayden JE.  TRPM4 channels couple purinergic receptor mechanoactivation and myogenic tone development in cerebral parenchymal arterioles.  J Cereb Blood Flow Metab.  2014 Aug 6.  doi:  10.1038/jbfm.2014.139.  PMID:  24099756

2014  Cipolla MJ, Chan SL, Sweet J, Tavares MJ, Gokina N, Brayden JE.  Postischemic reperfusion casues smooth muscle calcium sensitization and vasoconstriction of parenchymal arterioles.  Stroke.  2014 Aug;  45(8):  2425-2430.  doi:  10.1161/STROKEAHA.114.005888.  PMID:  24968928

2014  Cipolla MJ, Sweet J, Chan SL, Tavares MJ, Gokina N, Brayden JE.  Increased pressure-induced tone in rat parenchymal arterioles vs. middle cerebral arterioles:  role of ion channels and calcium sensitivity.  J Appl Physiol (1985).  2014 Jul 1;  117(1):  53-59.  doi:  10.1152/japplyphysiol.00253.2014.  PMID:  24790017, PMCID:  PMC4101583

2014  Mercado J, Baylie R, Navedo MF, Yuan C, Scott JD, Nelson MT, Brayden JE, Santana LF.  Local control of RPV4 channels by AKAP150-targeted PKC in arterial smooth muscle.  J Gen Physiol.  2014 May:  143(5):  559-575.  doi:  10.1085/jgp.201311050.  PMID:  24778429, PMCID:  PMC4003184

2013  Dabertrand F, Hannah RM, Pearson JM, Hill-Eubanks DC, Brayden JE, Nelson MT.  Prostaglandin E2, a postulated astrocyte-derived neurovascular coupling agent, constricts rather than dilates parenchymal arterioles.  J Cereb Blood Flow Metab.  2013 Apri;  33(4):  479-482.  doi:  10.1038/jcbfm.2013.9.  PMID:  23385200, PMCID:  PMC3618402

2013  Dabertrand F, Nelson MT, Brayden JE.  Ryanodine receptors, calcium signaling, and regulation of vascular tone in the cerebral parenchymal microcirculation.  Microcirculation.  2013 May; 20(4):  307-316.  doi:  10.1111/micc.12027.  PMID:  23216877, PMCID:  PMC3612564

2013  Brayden JE, Li Y, Tavares MJ.  Purinergic receptors regulate myogenic tone in cerebral parenchymal arterioles.  J Cereb Blood Flow Metab.  2013 Feb;  33(2):  393-399.  doi:  10.1038/jcbfm.2012.169.  PMID:  23168530, PMCID:  PMC3564200

2012  Dabertrand F, Nelson MT, Brayden JE.  Acidosis dilates brain parenchymal arterioles by conversion of calcium waves to sparks to activate BK channels.  Circ Res.  2012 Jan 20;  110(2):  285-294.  doi:  10.1161/CICRESAHA.111.248145.  PMID:  22095728,  PMCID:  PMC3505882

2011 Nystoriak MA, O'Connor KP, Sonkusare SK, Brayden JE, Nelson MT, Wellman GC. Fundamental increase in pressure-dependent constriction of brain parenchymal arteioles from subarachnoid hemorrhage model rats due to membrane depolarization. Am J Physiol Heart Circ Physiol. 300(3):H803-12, 2011.

2011 Koide M, Nystoriak MA, Brayden JE, Wellman GC. Impact of subarachnoid hemorrhage on local and global calcium signaling in cerebral artery myocytes. Acta Neurochir Suppl. 2011;  110(Pt 1):  145-150.  doi:  10.1007/978-3-7091-0353-1_25.  PMID:  21116930, PMCID:  PMC3057755

2011 Baylie RL, Brayden JE. TRPV channels and vascular function. Acta Physiol (Oxf).  2011 Sep: 203(1):  99-116.  doi: 10.1111/j.1748-1716.2010.02217, 2010.  PMID:  21062421, PMCID:  PMC3134601