University of Vermont

College of Medicine

Department of Pharmacology

Bio for Joseph E. Brayden, Ph.D.
Joseph E. Brayden, Ph.D.

Joseph E. Brayden, Ph.D.

Department of Pharmacology

Contact Information
Office Location:
Given B303




1973 B.S. (Biology) - Union College, Schenectady, N.Y.

1982 Ph.D. (Physiology & Biophysics) - University of Vermont, College of Medicine

Awards and Honors

2014 Distinguished Investigator Award, Cardiovascular Institute of Vermont

1992 - 1996 Member of the Experimental Cardiovascular Sciences study section (Division of Research Grants, NIH)

1990 - 1995 Established Investigator of the American Heart Association

1986 - 1989 PHS NIH New Investigator Award

1983 - 1985 PHS NRSA Postdoctoral Fellowship

1973 Cum Laude graduate, Union College

1969 - 1973 Clark Foundation Scholarship (full undergraduate tuition and fees)

1969 - 1973 New York State Regents Scholarship

1968 National Science Foundation Summer Fellowship, Brown University


For a complete list of Joseph E. Brayden's publications, please visit PubMed

2015  Early S, Brayden JE.  Transient receptor potential channels in the vasculature.  Physiol Rev.  doi:  10.1152/physrev.00026.2014.  PMID:  25834234

2015  Dabertrand F, Kroigaard C, Bonev AD, Cognat E, Dalsgaard T, Domenga-Denier V, Hill-Eubanks DC, Brayden JE, Joutel A, Nelson MT.  Potassium channelopathy-like defect underlies early-stage cerebrovascular dysfunction in genetic model of small vessel disease.  Proc Natl Acad Sci USA.  doi:  10.1073/pnas.1420765112.  PMID:  25646445, PMCID:  PMC4343103

2014  Li Y, Baylie RL, Tavares MJ, Brayden JE.  TRPM4 channels couple purinergic receptor mechanoactivation and myogenic tone development in cerebral parenchymal arterioles.  J Cereb Blood Flow Metab.  2014 Aug 6.  doi:  10.1038/jbfm.2014.139.  PMID:  24099756, PMCID:  PMC4269733

2014  Cipolla MJ, Chan SL, Sweet J, Tavares MJ, Gokina N, Brayden JE.  Postischemic reperfusion casues smooth muscle calcium sensitization and vasoconstriction of parenchymal arterioles.  Stroke.  2014 Aug;  45(8):  2425-2430.  doi:  10.1161/STROKEAHA.114.005888.  PMID:  24968928, PMCID:  PMC4144269

2014  Cipolla MJ, Sweet J, Chan SL, Tavares MJ, Gokina N, Brayden JE.  Increased pressure-induced tone in rat parenchymal arterioles vs. middle cerebral arterioles:  role of ion channels and calcium sensitivity.  J Appl Physiol (1985).  2014 Jul 1;  117(1):  53-59.  doi:  10.1152/japplyphysiol.00253.2014.  PMID:  24790017, PMCID:  PMC4101583

2014  Mercado J, Baylie R, Navedo MF, Yuan C, Scott JD, Nelson MT, Brayden JE, Santana LF.  Local control of RPV4 channels by AKAP150-targeted PKC in arterial smooth muscle.  J Gen Physiol.  2014 May:  143(5):  559-575.  doi:  10.1085/jgp.201311050.  PMID:  24778429, PMCID:  PMC4003184

2013  Dabertrand F, Hannah RM, Pearson JM, Hill-Eubanks DC, Brayden JE, Nelson MT.  Prostaglandin E2, a postulated astrocyte-derived neurovascular coupling agent, constricts rather than dilates parenchymal arterioles.  J Cereb Blood Flow Metab.  2013 Apri;  33(4):  479-482.  doi:  10.1038/jcbfm.2013.9.  PMID:  23385200, PMCID:  PMC3618402

2013  Dabertrand F, Nelson MT, Brayden JE.  Ryanodine receptors, calcium signaling, and regulation of vascular tone in the cerebral parenchymal microcirculation.  Microcirculation.  2013 May; 20(4):  307-316.  doi:  10.1111/micc.12027.  PMID:  23216877, PMCID:  PMC3612564

2013  Brayden JE, Li Y, Tavares MJ.  Purinergic receptors regulate myogenic tone in cerebral parenchymal arterioles.  J Cereb Blood Flow Metab.  2013 Feb;  33(2):  393-399.  doi:  10.1038/jcbfm.2012.169.  PMID:  23168530, PMCID:  PMC3564200

2012  Dabertrand F, Nelson MT, Brayden JE.  Acidosis dilates brain parenchymal arterioles by conversion of calcium waves to sparks to activate BK channels.  Circ Res.  2012 Jan 20;  110(2):  285-294.  doi:  10.1161/CICRESAHA.111.248145.  PMID:  22095728,  PMCID:  PMC3505882

2011 Nystoriak MA, O'Connor KP, Sonkusare SK, Brayden JE, Nelson MT, Wellman GC. Fundamental increase in pressure-dependent constriction of brain parenchymal arteioles from subarachnoid hemorrhage model rats due to membrane depolarization. Am J Physiol Heart Circ Physiol. 300(3):H803-12, 2011. doi:  10.1152/ajpheart.00760.2010.  PMID:  21148767, PMCID:  PMC3064296

2011 Koide M, Nystoriak MA, Brayden JE, Wellman GC. Impact of subarachnoid hemorrhage on local and global calcium signaling in cerebral artery myocytes. Acta Neurochir Suppl. 2011;  110(Pt 1):  145-150.  doi:  10.1007/978-3-7091-0353-1_25.  PMID:  21116930, PMCID:  PMC3057755

2011 Baylie RL, Brayden JE. TRPV channels and vascular function. Acta Physiol (Oxf).  2011 Sep: 203(1):  99-116.  doi: 10.1111/j.1748-1716.2010.02217, 2010.  PMID:  21062421, PMCID:  PMC3134601