University of Vermont

College of Medicine

Department of Pharmacology

Bio for Adrian D. Bonev, Ph.D.
Adrian D. Bonev, Ph.D.

Adrian D. Bonev, Ph.D.

Research Assistant Professor
Department of Pharmacology


Contact Information
E-mail: Adrian.Bonev@uvm.edu
Phone:
(802)656-3889
Office Location:
Given C Bldg, C315

Education

Dr. Bonev received his B.A. from University of Sofia, Sofia, Bulgaria and his Ph.D. in Biology from Institute of Physiology, Bulgarian Academy of Sciences. His postdoctoral training was at University of Cologne, Cologne, Germany.

Research Interests

Dr. Bonev’s research is focused on understanding the role of cell membrane and sarcoplasmic reticulum in the control of smooth muscle contractility. A variety of techniques such as patch clamp technique, fluorescent imaging of single vascular smooth muscle cells, laser confocal microscopy are used to study the role of cell membrane ion channels and Ca2+ release (Ca-sparks) from sarcoplasmic reticulum in the regulation of vascular tone and the contractility of some non vascular types of smooth muscle, and their modulation by hormones and neurotransmitters as well.

Publications

For a complete list of Adrian D. Bonev's publications, visit PubMed

2014  Sonkusare SK, Dalsgaard T, Bonev AD, Hill-Eubanks DC, Kotlikoff MI, Scott JD, Santana LF, Nelson MT.  AKAP150-dependent cooperative TRPV4 channel gating is central to endothelium-dependent vasodilation and is disrupted n hypertension.  Sci Signal.  2014 Jul 8; 7(333):  ra66.  doi:  10.1126/scisignal.2005052.  PMCID:  25005230.  Journal cover.

2014  Nausch B, Rode F, Jorgensen S, Nardi A, Korsgaard MP, Hougaard C, Brown WD, Bonev AD, Dyhring T, Strobaek D, Olesen SP, Christophersen P, Grunnet M, Nelson MT, Ronn LC.  NS19504:  a novel BK channel activator with relaxing effect on bladder smooth muscle spontaneous phasic contractions.  J Pharmacol Exp Ther.  2014 Jun 20.  doi:  10.1124/jpet.113.212662.  PMID:  24951278

2013  Gokina NI, Bonev AD, Gokin AP, Goloman G.  Role of impaired endothelial cell Ca(2+) signaling in uteroplacental vascular dysfunction during diabetic rat pregnancy.  Am J Physiol Heart Circ Physiol.  2013 Apr 1;  304(7):  H935-H945.  doi:  10.1152/ajpheart.00513.2012.  PMID:  23376827

2013  Koide M, Bonev AD, Nelson MT, Wellman GC.  Subarachnoid blood converts neutrally evoked vasodilation to vasoconstriction in rat brain cortex.  Acta Neurochir Suppl.  2013;  115:  167-171.  doi:  10.1007/978-3-7091-1192-5_32.  PMID:  22890664

2012  Sonkusare SK, Bonev AD, Ledoux J, Liedtke W, Kotlikoff MI, Heppner TJ, Hill-Eubanks DC Nelson MT.  Elementary Ca2+ signals through endothelial TRPV4 channels regulate vascular function.  Science.  2012 May 4:  336(6081):  597-601.  doi:  10.1126/science.1216283.  PMID:  22556255.  PMCID:  PMC3715993.  Editor's Choice (L.B. Ray, Blood Pressure Gauge. Sci. Signal. 5, ec131), featured in a Perspective in the same issue and a Podcast:  http://podcasts.aaas.org/science_signaling/ScienceSignaling_120508.mp3

2012  Koide M, Bonev AD, Nelson MT, Wellman GC.  Inversion of neurovascular coupling by subarachnoid blood depends on large-conductance Ca2+-activated K+ (BK) channels.  Proc Natl Acad Sci USA.  2012 May 22;  109(21):  E1387-E1395.  doi:  10.1073/pnas.1121359109.  PMID:  22547803, PMCID:  PMC3361424

2012  Nausch LW, Bonev AD, Heppner TJ, Tallini YN, Kotlikoff MI, Nelson MT.  Sympathetic nerve stimulation induces local endothelial calcium signals to oppose vasoconstriction of mouse mesenteric arteries.  Am J Physiol Heart Circ Physiol.  2012 Feb 1:  302(3):  H594-H602.  doi:  10.1152/ajpheart.0073.2011.  PMID:  22140050.  PMCID:  PMC3353782.  Featured in a Podcast:  http://ajpheart.podbean.com/2012/03/14/nerve-induced-ec-ca2-signals-oppose-vasoconstriction/

2011 Hannah RM, Dunn KM, Bonev AD, Nelson MT. Endothelial SK(Ca) and IK(Ca) channels regulate brain parenchymal arteriolar diameter and cortical cerebral blood flow. J Cereb Blood Flow Metab. 2011 May;  31(5):  1175-1186.  doi:  10.1038/jcb fm.2010.214.  PMID:  21179072, PMCID:  PMC3099631.  Featured paper with commentary and journal cover.

2011 Koide M, Nystoriak MA, Krishnamoorthy G, O'Connor KP, Bonev AD, Nelson MT, Wellman GC.  Reduced Ca2+ spark activity after subarachnoid hemorrhage disables BK channel control of cerebral artery tone.  J Cereb Blood Flow Metab. 2011 Jan; 31(1):  3-16.  doi:  10.1038/jcbfm.2010.143.  PMID:  20736958, PMCID:  PMC3049462

2010  Girouard H, Bonev AD, Hannah RM, Meredith A, Aldrich RW, Nelson MT.  Astrocytic endfoot Ca2+ and BK channels determine both arteriolar dilation and constriction.  Proc Natl Acad Sci U S A. 2010 Feb 23;  107(8):  3811-3816.  doi:  10.1073/pnas.0914722107.  PMID:  20133576, PMCID:  PMC2840528

2008  Obata F, Tohyama K, Bonev AD, Kolling GL, Keepers TR, Gross LK, Nelson MT, Sato S, Obrig TG.  Shiga toxin 2 affects the central nervous system through receptor globotriaosylceramide localized to neurons. J Infect Dis.  2008 Nov 1;  198(9):  1398-1406.  doi:  10.1086/591911.  NIHMS102367.  PMID:  18754742, PMCID:  PMC2684825

2008  Ledoux J, Taylor MS, Bonev AD, Hannah RM, Solodushko V, Shui B, Tallini Y, Kotlikoff MI, Nelson MT.  Functional architecture of inositol 1,4,5-triphosphate signaling in restricted spaces of myoendothelial projections. Proc Natl Acad Sci U S A.  2008 Jul 15;  105(28): 9627-9632.  doi:  10.1073/pnas.0801963105.  PMCID:  PMC2474537

2008  Michael SK, Surk HK, Wang Y, Zhu Y, Blanton R, Jamnongjit M, Aronovitz M, Baur W, OhtaniK, Wilerson MK, Bonev AD, Nelson MT, Karas RH, Mendelsohn ME.  High blood pressure arising from a defect in vascular function.  Proc Natl Acad Sci USA.  2008 May 6;  105(18):  6702-6707.  doi:  10.1073/pnas.0802128105.  PMID:  18448676, PMCID:  PMC2373316

2008  Ledoux J, Bonev AD, Nelson MT.  Ca2+-activated K+ channels in murine endothelial cells:  block by intracellular calcium and magnesium.  J Gen Physiol.  2008 Feb;  131(2):  125-135.  doi:  10.1085/jgp.2007-9875.  PMID:  18195387, PMCID:  2213563