Dr. Bonev received his B.A. from University of Sofia, Sofia, Bulgaria and his Ph.D. in Biology from Institute of Physiology, Bulgarian Academy of Sciences. His postdoctoral training was at University of Cologne, Cologne, Germany.
Dr. Bonev’s research is focused on understanding the role of cell membrane and sarcoplasmic reticulum in the control of smooth muscle contractility. A variety of techniques such as patch clamp technique, fluorescent imaging of single vascular smooth muscle cells, laser confocal microscopy are used to study the role of cell membrane ion channels and Ca2+ release (Ca-sparks) from sarcoplasmic reticulum in the regulation of vascular tone and the contractility of some non vascular types of smooth muscle, and their modulation by hormones and neurotransmitters as well.
2011 Hannah RM, Dunn KM, Bonev AD, Nelson MT. Endothelial SK(Ca) and IK(Ca) channels regulate brain parenchymal arteriolar diameter and cortical cerebral blood flow. J Cereb Blood Flow Metab. 31(5):1175-86, 2011.
2011 Koide M, Nystoriak MA, Krishnamoorthy G, O'Connor KP, Bonev AD, Nelson MT, Wellman GC. Reduced Ca2+ spark activity after subarachnoid hemorrhage disables BK channel control of cerebral artery tone. J Cereb Blood Flow Metab. 31(1):3-16, 2011.2010 Girouard H, Bonev AD, Hannah RM, Meredith A, Aldrich RW, Nelson MT. Astrocytic endfoot Ca2+ and BK channels determine both arteriolar dilation and constriction. Proc Natl Acad Sci U S A. 107(8):3811-6, 2010.
2008 Obata F, Tohyama K, Bonev AD, Kolling GL, Keepers TR, Gross LK, Nelson MT, Sato S, Obrig TG. Shiga toxin 2 affects the central nervous system through receptor globotriaosylceramide localized to neurons. J Infect Dis. 198(9):1398-406, 2008.2008 Ledoux J, Taylor MS, Bonev AD, Hannah RM, Solodushko V, Shui B, Tallini Y, Kotlikoff MI, Nelson MT. Functional architecture of inositol 1,4,5-triphosphate signaling in restricted spaces of myoendothelial projections. Proc Natl Acad Sci U S A. 105(28):9627-32, 2008.
For a complete list of Adrian D. Bonev's publications, visit PubMed