University of Vermont

College of Medicine

Department of Pharmacology

Bio for Adrian D. Bonev, Ph.D.
Adrian D. Bonev, Ph.D.

Adrian D. Bonev, Ph.D.

Research Assistant Professor
Department of Pharmacology

Contact Information
Office Location:
Given C Bldg, C315


Dr. Bonev received his B.A. from University of Sofia, Sofia, Bulgaria and his Ph.D. in Biology from Institute of Physiology, Bulgarian Academy of Sciences. His postdoctoral training was at University of Cologne, Cologne, Germany.

Research Interests

Dr. Bonev’s research is focused on understanding the role of cell membrane and sarcoplasmic reticulum in the control of smooth muscle contractility. A variety of techniques such as patch clamp technique, fluorescent imaging of single vascular smooth muscle cells, laser confocal microscopy are used to study the role of cell membrane ion channels and Ca2+ release (Ca-sparks) from sarcoplasmic reticulum in the regulation of vascular tone and the contractility of some non vascular types of smooth muscle, and their modulation by hormones and neurotransmitters as well.


For a complete list of Adrian D. Bonev's publications, visit PubMed

2015  Gokina NI, Bonev AD, Phillips J, Gokin AP, Veilleux K, Oppenheimer K, Goloman G.  Impairment of IKCa Channels Contributes to Uteroplacental Endothelial Dysfunction in Rat Diabetic Pregnancy.  Am J Physiol Heart Circ Physiol.  doi:  10.1152/ajpheart.00901.2014.  PMID:  26092991

2015  Dabertrand F, Kroigaard C, Bonev AD, Cognat E, Dalsgaard T, Domenga-Denier V, Hill-Eubanks DC, Brayden JE, Joutel A, Nelson MT.  Potassium channelopathy-like defect underlies early-stage cerebrovascular dysfunction in a genetic model of small vessel disease.  Proc Natl Acad Sci USA.  doi:  10.1073/pnas.1420765112.  PMID:  25646445,  PMCID:  PMC4343103

2014  Sonkusare SK, Dalsgaard T, Bonev AD, Hill-Eubanks DC, Kotlikoff MI, Scott JD, Santana LF, Nelson MT.  AKAP150-dependent cooperative TRPV4 channel gating is central to endothelium-dependent vasodilation and is disrupted n hypertension.  Sci Signal.  doi:  10.1126/scisignal.2005052.  PMID:  25005230, PMCID:  PMC4403000.  Journal cover.

2014  Nausch B, Rode F, Jorgensen S, Nardi A, Korsgaard MP, Hougaard C, Brown WD, Bonev AD, Dyhring T, Strobaek D, Olesen SP, Christophersen P, Grunnet M, Nelson MT, Ronn LC.  NS19504:  a novel BK channel activator with relaxing effect on bladder smooth muscle spontaneous phasic contractions.  J Pharmacol Exp Ther.  doi:  10.1124/jpet.113.212662.  PMID:  24951278, PMCID:  PMC4152884

2013  Gokina NI, Bonev AD, Gokin AP, Goloman G.  Role of impaired endothelial cell Ca(2+) signaling in uteroplacental vascular dysfunction during diabetic rat pregnancy.  Am J Physiol Heart Circ Physiol.  doi:  10.1152/ajpheart.00513.2012.  PMID:  23376827, PMCID:  PMC3624897

2013  Koide M, Bonev AD, Nelson MT, Wellman GC.  Subarachnoid blood converts neutrally evoked vasodilation to vasoconstriction in rat brain cortex.  Acta Neurochir Suppl.  doi:  10.1007/978-3-7091-1192-5_32.  PMID:  22890664, PMCID:  PMC3684063

2012  Sonkusare SK, Bonev AD, Ledoux J, Liedtke W, Kotlikoff MI, Heppner TJ, Hill-Eubanks DC Nelson MT.  Elementary Ca2+ signals through endothelial TRPV4 channels regulate vascular function.  Science.  doi:  10.1126/science.1216283.  PMID:  22556255.  PMCID:  PMC3715993.  Editor's Choice (L.B. Ray, Blood Pressure Gauge. Sci. Signal. 5, ec131), featured in a Perspective in the same issue and a Podcast:

2012  Koide M, Bonev AD, Nelson MT, Wellman GC.  Inversion of neurovascular coupling by subarachnoid blood depends on large-conductance Ca2+-activated K+ (BK) channels.  Proc Natl Acad Sci USA.  doi:  10.1073/pnas.1121359109.  PMID:  22547803, PMCID:  PMC3361424

2012  Nausch LW, Bonev AD, Heppner TJ, Tallini YN, Kotlikoff MI, Nelson MT.  Sympathetic nerve stimulation induces local endothelial calcium signals to oppose vasoconstriction of mouse mesenteric arteries.  Am J Physiol Heart Circ Physiol.  doi:  10.1152/ajpheart.0073.2011.  PMID:  22140050.  PMCID:  PMC3353782.  Featured in a Podcast:

2011 Hannah RM, Dunn KM, Bonev AD, Nelson MT. Endothelial SK(Ca) and IK(Ca) channels regulate brain parenchymal arteriolar diameter and cortical cerebral blood flow. J Cereb Blood Flow Metab. 2011 May;  31(5):  1175-1186.  doi:  10.1038/jcb fm.2010.214.  PMID:  21179072, PMCID:  PMC3099631.  Featured paper with commentary and journal cover.

2011 Koide M, Nystoriak MA, Krishnamoorthy G, O'Connor KP, Bonev AD, Nelson MT, Wellman GC.  Reduced Ca2+ spark activity after subarachnoid hemorrhage disables BK channel control of cerebral artery tone.  J Cereb Blood Flow Metab.  doi:  10.1038/jcbfm.2010.143.  PMID:  20736958, PMCID:  PMC3049462

2010  Girouard H, Bonev AD, Hannah RM, Meredith A, Aldrich RW, Nelson MT.  Astrocytic endfoot Ca2+ and BK channels determine both arteriolar dilation and constriction.  Proc Natl Acad Sci U S A.  doi:  10.1073/pnas.0914722107.  PMID:  20133576, PMCID:  PMC2840528