University of Vermont

College of Medicine

Department of Pharmacology

Bio for Mark T. Nelson, Ph.D.
Mark T. Nelson, Ph.D.

Mark T. Nelson, Ph.D.

Chair and University Distinguished Professor
Department of Pharmacology

Contact Information
(802) 656-2500
Office Location:
89 Beaumont Ave, Given B333A, Burlington, VT 05405




1973 Undergraduate studies Swarthmore College, Swarthmore, PA
1976 B.A., Mathematics & Biology with Honors Tufts University, Medford, MA
1980 Ph.D., Neural Sciences Washington University, St. Louis, MO  Advisor: Prof. M.P. Blaustein


1990-1991 Consultant for Glaxo (Research Triangle, NC)
1991-1994 Consultant for Lederle Laboratories, American Cyanamid (Pearl River, NY)
1992-1999 Consultant for Zeneca (ICI) Pharmaceuticals, (Wilmington, DE).
1997-1999 Industrial Partnership with Wyeth-Ayerst Pharmaceuticals, Princeton, New Jersey

Academic Appointments

1996 - Present  Chair, Department of Pharmacology, College of Medicine, University of Vermont, Burlington, VT
10/06 - Present  Professor, Institute of Cardiovascular Science, School of Medicine, University of Manchester, Manchester, UK
10/12 - Present  Visiting Professor of Pharmacology, University of Oxford, Oxford, UK
1995 - 1996  Interim Chair, Department of Pharmacology, University of Vermont
1993 - Present  Professor, Department of Molecular Physiology & Biophysics, University of Vermont (Secondary)
1992 - Present  Professor, Department of Pharmacology, College of Medicine, University of Vermont
1990 - 1992  Associate Professor with Tenure, Department of Pharmacology, University of Vermont
1986 - 1990  Assistant Professor, Department of Pharmacology, University of Vermont
1984 - 1986  Assistant Professor, Department of Pharmacology, University of Miami School of Medicine, Miami, FL
1982 - 1984  Research Assistant Professor, Department of Physiology, University of Maryland School of Medicine, Baltimore, MD.
1981 - 1982  Research Fellow of the Alexander von Humboldt Stiftung, Fakultät für Biologie, Universität Konstanz, West Germany.
1980 - 1981  Research Fellow of the American Heart Association, Dept. of Physiology, University of Maryland, Baltimore, MD

Awards and Honors

2013  Keynote Speaker at the 6th International Conference on cGMP, Erfurt, Germany

2012  North American Coordinator, Fondation Leducq Transatlantic Networks of Excellence Grant
2008 - 2018 MERIT Award, NIH
2009 Fellow, Biophysical Society
2009 University Distinguished Professor, University of Vermont
2001 Fellow, American Heart Association and the Council on Basic Cardiovascular Sciences
1998 Vermont Academy of Sciences and Engineering, member
1996 University Scholar, University of Vermont
1985 - 1990 Established Investigator of the American Heart Association
1981 - 1982, 1984 Alexander von Humboldt-Stiftung Fellowship, Universität Konstanz, West Germany
1982 Louis N. Katz Research Prize for Young Investigators, Honorable Mention (AHA)
1980 - 1981 American Heart Association Fellowship, University of Maryland
1978 - 1980 National Institutes of Health Predoctoral Fellowship, Washington University
1974 National Science Foundation Summer Fellowship, Swarthmore College


For a complete list of Mark T. Nelson's publications, please visit PubMed.
For Google Scholar Citations Profile, please visit:   Mark T. Nelson 

2014  Hill-Eubanks DC, Gonzales AL, Sonkusare SK, Nelson MT.  Vascular TRP Channels:  Performing Under Pressure and Going with the Flow.  Physiol Rev. - in press

2014  Nausch B, Rode F, Jorgensen S, Nardi A, Korsgaard MP, Hougaard C, Brown WD, Bonev AD, Dyhring T, Strobaek D, Olesen SP, Christophersen P, Grunnet M, Nelson MT, Ronn LC.  NS19504:  a novel BK channel activator with relaxing effect on bladder smooth muscle spontaneous phasic contractions.  J Pharmacol Exp Ther.  Pii: jpet.113.212662.  PMID:  24951278

2014  Gonsales AL, Yang Y, Sullivan MN, Sanders L.  Dabertrand F, Hill-Eubanks DC, Nelson MT, Earley S.  A PLCy1-Dependent, Force-Sensitive Signaling Network in the Myogenic Constriction of Cerebral Arteries.  Science Signaling.  doi:  10.1126/scisignal.200732.  PMID:  24866019

2014  Longden TA, Dabertrand F, Hill-Eubanks DC, Hammack SE, Nelson MT.  Stress-induced glucocorticoid signaling remodels neurovascular coupling through impairment of cerebrovascular inwardly rectifying K+ channel function.  Proc Natl Acad Sci USA.  doi:  10.1073/pnas.1401811111.  PMID:  24808139, PMCID:  PMC4034203

2014  Mercado J, Baylie R, Navedo MF, Yuan C, Scott JD, Nelson MT, Brayden JE, Santana LF.  Local control of TRPV4 channels by AKAP150-targeted PKC in arterial smooth muscle.  J Gen Physiol.  doi:  10.1085/jgp.201311050.  PMID:  24778429, PMCID:  PMC4003184

2014  Krishnamoorthy G, Sonkusare SK, Heppner TJ, Nelson MT.  Opposing roles of smooth muscle BK channels and ryanodine receptors in the regulation of nerve-evoked constriction of mesenteric resistance arteries.  Am J Physiol Heart Circ Physiol.  doi:  10.1152/ajpheart.00866.2013.  PMID:  24508642, PMCID:  PMC3962638

2013  Dunn KM, Nelson MT.  Neurovascular signaling in the brain and the pathological consequences of hypertension.  Am J Physiol Heart Circ Physiol.  doi:  10.1152/ajpheart.00364.2013.  PMID:  24163077, PMCID:  PMC3920149

2013  Cipolla MJ, Sweet JG, Gokina NI, White SL, Nelson MT.  Mechanisms of enhanced basal tone of brain parenchymal arterioles during early postischemic reperfusion:  Role of ET-1-induced peroxynitrite generation.  J Cereb Blood Flow Metab  June 19, 2013.  doi:  10.1038, jcbfm 207399.  PMID:  23778163

2013  Dunn KM, Hill-Eubanks DC, Liedtke WB, Nelson MT.  TRPV4 channels stimulate Ca2+ induced Ca2+ release in astrocytic endfeet and amplify neurovascular coupling responses.  Proc Natl Acad Sci USA, April 9, 2013; 110(15):  6157-6162.  doi: 10.1073/pnas 1216514110.  PMID:  23530219

2013  Dabertrand F, Hannah RM, Pearson JM, Hill-Eubanks DC, Brayden JE, Nelson MT.  Prostaglandin E2, a postulated astrocyte-derived neurovascular coupling agent, constricts rather than dilates parenchymal arterioles.  J Cereb Blood Flow Metab.  Feb 6, 2013, 10.1038/jcbfm.2013.9  PMID:  23385200

2013  Koide M, Bonev AD, Nelson MT, Wellman GC.  Subarachnoid blood converts neutrally evoked vasodilation to vasoconstriction in rat brain cortex.  Acta Neurchir, Suppl.  2013; 115: 167-171.  PMID:  22890664

2012  Koide M, Bonev AD, Nelson MT, Wellman GC.  Inversion of neurovascular coupling by subarachnoid blood depends on large-conductance Ca2+- activated K+ (BK) channels.  Proc Natl Acad Sci USA.  May 22, 2012:  109(21):  E1387-95.  PMID:  22547803

2012  Sonkusare SK, Bonev AD, Heppner TJ, Ledoux J, Liedtke W, Kotlikoff MI, Hill-Eubanks DC and Nelson MT.  Elementary Ca2+ signals through endothelial TRPV4 channels regulate vascular function.  Science, May 4, 2012.  336(6081):  597-601.  PMID 22556255.  Editor's choice (L.B. Ray, Blood Pressure Gauge.  Sci. Signal 5, ec131).  Featured in a Perspective in the same issue (Lederer, et al.) and a Podcast (

2012  Nausch LW, Bonev AD, Heppner TJ, Tallini YN, Kotlikoff MI, Nelson MT.  Sympathetic nerve stimulation induces local endothelial calcium signals to oppose vasoconstriction of mouse mesenteric arteries.  Am J Physiol Heart Circ Physiol, Feb 1, 2012.  doi 10.1152/ajpheart.00773.2011.  PMID:  22140050.  Featured in a Podcast:  (

2012  Dabertrand F, Nelson MT, Brayden JE.  Acidosis dilates brain parenchymal arterioles by conversion of calcium waves to sparks to activate BK channels.  Circulation Research.  Jan 20, 2012.  110(2): 285-294.  PMID:  22095728

2012  Lavoie B, Nausch B, Zane E, Leonard M, Balemba O, Bartoo A, Wilcox R, Nelson MT, Carey MC, Mawe G.  Disruption of gallbladder smooth muscle function is an early feature in the development of cholesterol gallstone disease.  Neurogastroenterology and Motility, May 24, 2012.  doi:  10.111/j.  1365-2982.2012.01935.x.  PMID:  22621672

2012  Dabertrand F, Nelson MT, Brayden JE.  Ryanodine receptors, calcium signaling and regulation of vascular tone in the cerebral parenchymal microcirculation.  Microcirculation Dec 8, 2012.  doi 10.111/micc:  12027.  PMID:  23216877