University of Vermont

College of Medicine

Department of Pharmacology

Bio for Mark T. Nelson, Ph.D.
Mark T. Nelson, Ph.D.

Mark T. Nelson, Ph.D.

Chair and University Distinguished Professor
Department of Pharmacology


Contact Information
E-mail: Mark.Nelson@uvm.edu
Phone:
(802) 656-2500
Office Location:
89 Beaumont Ave, Given B333A, Burlington, VT 05405

Website

Lab

Education

1973 Undergraduate studies Swarthmore College, Swarthmore, PA
1976 B.A., Mathematics & Biology with Honors Tufts University, Medford, MA
1980 Ph.D., Neural Sciences Washington University, St. Louis, MO  Advisor: Prof. M.P. Blaustein

Expertise

1990-1991 Consultant for Glaxo (Research Triangle, NC)
1991-1994 Consultant for Lederle Laboratories, American Cyanamid (Pearl River, NY)
1992-1999 Consultant for Zeneca (ICI) Pharmaceuticals, (Wilmington, DE).
1997-1999 Industrial Partnership with Wyeth-Ayerst Pharmaceuticals, Princeton, New Jersey

Academic Appointments

1996 - Present  Chair, Department of Pharmacology, College of Medicine, University of Vermont, Burlington, VT
10/06 - Present  Professor, Institute of Cardiovascular Science, School of Medicine, University of Manchester, Manchester, UK
10/12 - Present  Visiting Professor of Pharmacology, University of Oxford, Oxford, UK
1995 - 1996  Interim Chair, Department of Pharmacology, University of Vermont
1993 - Present  Professor, Department of Molecular Physiology & Biophysics, University of Vermont (Secondary)
1992 - Present  Professor, Department of Pharmacology, College of Medicine, University of Vermont
1990 - 1992  Associate Professor with Tenure, Department of Pharmacology, University of Vermont
1986 - 1990  Assistant Professor, Department of Pharmacology, University of Vermont
1984 - 1986  Assistant Professor, Department of Pharmacology, University of Miami School of Medicine, Miami, FL
1982 - 1984  Research Assistant Professor, Department of Physiology, University of Maryland School of Medicine, Baltimore, MD.
1981 - 1982  Research Fellow of the Alexander von Humboldt Stiftung, Fakultät für Biologie, Universität Konstanz, West Germany.
1980 - 1981  Research Fellow of the American Heart Association, Dept. of Physiology, University of Maryland, Baltimore, MD

Awards and Honors

2016  Keynote Speaker, FASEB Smooth Muscle Conference, Lisbon, Portugal
2016  Vermont Academy of Arts and Sciences Fellowship
2016  Paul M. Vanhoutte Distinguished Lecture in Vascular Pharmacology, Experimental Biology 2016 (EB 2016), San Diego, CA, sponsored by ASPET
2015  Thomas C. Vary Distinguished Lecturer, University of Pennsylvania, Hershey, PA
2015  Keynote Speaker, Society of General Physiologists, Symposium on Macromolecular Local Signaling Complexes, Woods Hole, MA
2015  American Physiological Society, Annual Reviews Award for Scientific Reviewing
2015  Kaley Lecture Speaker, Experimental Biology 2015, Boston, MA

2013  Keynote Speaker at the 6th International Conference on cGMP, Erfurt, Germany

2012  North American Coordinator, Fondation Leducq Transatlantic Networks of Excellence Grant
2009 Fellow, Biophysical Society
2009 University Distinguished Professor, University of Vermont
2008 - 2018 MERIT Award, NIH
2001 Fellow, American Heart Association and the Council on Basic Cardiovascular Sciences
1998 Vermont Academy of Sciences and Engineering, member
1996 University Scholar, University of Vermont
1985 - 1990 Established Investigator of the American Heart Association
1981 - 1982, 1984 Alexander von Humboldt-Stiftung Fellowship, Universität Konstanz, West Germany
1982 Louis N. Katz Research Prize for Young Investigators, Honorable Mention (AHA)
1980 - 1981 American Heart Association Fellowship, University of Maryland
1978 - 1980 National Institutes of Health Predoctoral Fellowship, Washington University
1974 National Science Foundation Summer Fellowship, Swarthmore College

Publications

For a complete list of Mark T. Nelson's publications, please visit PubMed.
For Google Scholar Citations Profile, please visit:   Mark T. Nelson 

2016  Capone C, Dabertrand F, Baron-Menguy C, Chalaris A, Ghezali L, Domenga-Denier V, Schmidt S, Huneau C, Rose-John S, Nelson MT, Joutel A.  Mechanistic insights into a TIMP3-sensitive pathway constitutively engaged in the regulation of cerebral hemodynamics.  Elife.  2016 Aug 1.  doi:  10.754/eLife.17536.  PMID:  27476853

2016  Mah W, Sonskusare SK, Wang T, Azeddine B, Pupavac M, Carrot-Zhang J, Hong K, Mejewski J, Harvey EJ, Russell L, Chalk C. Rosenblatt DS, Nelson MT, Séguin C.  Gain-of-function mutation in TRPV4 identified in patients with ostenonecrosis of the femoral head.  J Med Genet.  2016 June 21.  doi:  10.1136/jmedgenet-2016-103829.  PMID:  27330106

2016  Povlsen GK, Longden TA, Bonev AD, Hill-Eubanks DC, Nelson MT.  Uncoupling of neurovascular communication after transient global cerebral ischemia is caused by impaired parenchymal smooth muscle Kir channel function.  J Cereb Blood Flow Metab.  2016 Apr 6.  doi:  10.1177/0271678X16638350.  PMID:  27052838, PMCID:  PMC4929704

2016  Gonzales EJ, Heppner TJ, Nelson MT, Vizzard MA.  Purinergic signalling underlies transforming growth factor-beta mediated bladder afferent nerve hyperexcitability.  J Physiol.  2016 Mar 23.  doi:  10.1113/JP272148.  PMID:  27006168, PMCID:  PMC4929319

2016  Heppner TJ, Tykocki NR, Hill-Eubanks D, Nelson MT.  Transient contractions of urinary bladder smooth muscle are drivers of afferent nerve activity during filling.  J Gen Physiol.  2016 Mar 14.  doi:  10.1085/jgp.201511550.  PMID:  26976828, PMCID:  PMC4810069

2016  Sonkusare SK, Dalsgaard T, Bonev AD, Nelson MT.  Inward rectifier potassium (Kir2.1) channels as end-stage boosters of endothelium-dependent vasodilators.  J Physiol.  2016 Feb 3.  doi:  10.1113/JP271652.  PMID:  26840527, PMCID:  PMC4908010

2016  Villalab N, Sackheim A, Nunez I, Hill-Eubanks D, Nelson MT, Wellman GC, Freeman K.  Traumatic brain injury causes endothelium dysfunction in the systemic microcirculation through arginase-1-dependent uncoupling of endothelial nitric oxide synthase.  J Neurotrauma.  2016 Jan 13.  doi:  10.1089/neu.2015.4340.  PMID:  26757855

2016 Ye W, Chang RB, Bushman JD, Tu YH, Mulhall EM, WIlson CE, Cooper AJ, Chick WS, Hill-Eubanks DC, Nelson MT, Kinnamon SC, Liman ER.  K+ channel Kir2.1 functions in tandem with proton influx to mediate sour taste transduction.  Proc Natl Acad Sci USA.  2016 Jan 12.  doi:  10.1073/pnas.1514282112.  PMID:  26627720, PMCID:  PMC4720319

2015  Longden TA, Hill-Eubanks DC, Nelson MT.  Ion channel networks in the control of cerebral blood flow.  J Cereb Blood Flow Metab.  2015 Nov 9.  doi:  10.1177/0271678X15616138.  PMID:  26661232, PMCID:  PMC4794103

2015  Capone C, Cognat E, Ghezali L, Baron-Menguy C, Aubin D, Mesnard L, Stohr H, Domenga-Denier V, Nelson MT, Joutel A.  Reducing Timp3 or vitronectin ameliorates disease manifestations in CADASIL mice.  Ann Neurol.  2015 Dec 9.  doi:  10.1002/1n1.24573.  PMID:  26648042

2015  Mingin GC, Heppner TJ, Tykocki NR, Erickson CS, Vizzard MA, Nelson MT.  Social stress in mice induces urinary bladder overactivity and increases TRPV1 channel-dependent afferent nerve activity.  Am J Physiol Regul Integr Comp Physiol.  2015 Sept 15.  doi:  10.1152/ajpregu.00013.2015.  PMID:  26224686, PMCID:  PMC4591369

2015  Tykocki NR, Nelson MT.  Location, Location, Location:  Juxtaposed calcium-signaling microdomains as a novel model of the vascular smooth muscle myogenic response.  J Gen Physiol.  2015 Aug.  doi:  10.1085/jgp.201511468.  PMID:  26216858, PMCID:  PMC4516781

2015  Balbi M, Ghosh M, Longden TA, Jativa Vega M, Gesierich B, Hellal F, Lourbopoulos A, Nelson MT, Plesnila N.  Dysfunction of mouse cerebral arteries during early aging.  J Cereb Blood Flow Metab.  doi:  10.1038/jcbfm.2015.107.  PMID:  26058694

2015  Collier DM, Hill-Eubanks DC, Nelson MT.  Orchestrating Ca2+ influx through CaV1.2 and CaV3.x channels in human cerebral arteries.  J Gen Physiol.  doi:  10.1085/jgp.201511411.  PMID:  26009543, PMCID:  PMC4442783

2015 Joutel A, Haddad I, Ratelade J, Nelson MT.  Perturbations of the cerebrovascular matrisome:  a convergent mechanism in small vessel disease of the brain?  J Cereb Blood Flow Metab.  doi:  10.1038/jcbfm.2015.62.  PMID:  25853907, PMCID:  PMC4442783

2015  Dabertrand F, Kroigaard C, Bonev AD, Cognat E, Dalsgaard T, Domenga-Denier V, Hill-Eubanks DC, Brayden JE, Joutel A, Nelson MT.  Potassium channelopathy-like defect underlies early-stage cerebrovascular dysfunction in a genetic model of small vessel disease.  Proc Natl Acad Sci USA. doi:  10.1073/pnas.1420765112.  PMID:  25646445, PMCID:  PMC4343103

2015  Longden TA, Nelson MT.  Vascular Inward Rectifier K+ Channels as External K+ Sensors in the Control of Cerebral Blood Flow.  Microcirculation.  doi:  10.1111/micc.12190.  PMID:  25641345, PMCID:  PMC4404517