University of Vermont

College of Medicine

Department of Pharmacology

Bio for Mark T. Nelson, Ph.D.
Mark T. Nelson, Ph.D.

Mark T. Nelson, Ph.D.

Chair and University Distinguished Professor
Department of Pharmacology

Contact Information
(802) 656-2500
Office Location:
89 Beaumont Ave, Given B333A, Burlington, VT 05405




1973 Undergraduate studies Swarthmore College, Swarthmore, PA
1976 B.A., Mathematics & Biology with Honors Tufts University, Medford, MA
1980 Ph.D., Neural Sciences Washington University, St. Louis, MO  Advisor: Prof. M.P. Blaustein


1990-1991 Consultant for Glaxo (Research Triangle, NC)
1991-1994 Consultant for Lederle Laboratories, American Cyanamid (Pearl River, NY)
1992-1999 Consultant for Zeneca (ICI) Pharmaceuticals, (Wilmington, DE).
1997-1999 Industrial Partnership with Wyeth-Ayerst Pharmaceuticals, Princeton, New Jersey

Academic Appointments

1996 - Present  Chair, Department of Pharmacology, College of Medicine, University of Vermont, Burlington, VT
10/06 - Present  Professor, Institute of Cardiovascular Science, School of Medicine, University of Manchester, Manchester, UK
10/12 - Present  Visiting Professor of Pharmacology, University of Oxford, Oxford, UK
1995 - 1996  Interim Chair, Department of Pharmacology, University of Vermont
1993 - Present  Professor, Department of Molecular Physiology & Biophysics, University of Vermont (Secondary)
1992 - Present  Professor, Department of Pharmacology, College of Medicine, University of Vermont
1990 - 1992  Associate Professor with Tenure, Department of Pharmacology, University of Vermont
1986 - 1990  Assistant Professor, Department of Pharmacology, University of Vermont
1984 - 1986  Assistant Professor, Department of Pharmacology, University of Miami School of Medicine, Miami, FL
1982 - 1984  Research Assistant Professor, Department of Physiology, University of Maryland School of Medicine, Baltimore, MD.
1981 - 1982  Research Fellow of the Alexander von Humboldt Stiftung, Fakultät für Biologie, Universität Konstanz, West Germany.
1980 - 1981  Research Fellow of the American Heart Association, Dept. of Physiology, University of Maryland, Baltimore, MD

Awards and Honors

2015  Thomas C. Vary Distinguished Lecturer, University of Pennsylvania, Hershey, PA
2015  Keynote Speaker, Society of General Physiologists, Symposium on Macromolecular Local Signaling Complexes, Woods Hole, MA
2015  American Physiological Society, Annual Reviews Award for Scientific Reviewing
2015  Kaley Lecture Speaker, Experimental Biology 2015, Boston, MA

2013  Keynote Speaker at the 6th International Conference on cGMP, Erfurt, Germany

2012  North American Coordinator, Fondation Leducq Transatlantic Networks of Excellence Grant
2008 - 2018 MERIT Award, NIH
2009 Fellow, Biophysical Society
2009 University Distinguished Professor, University of Vermont
2001 Fellow, American Heart Association and the Council on Basic Cardiovascular Sciences
1998 Vermont Academy of Sciences and Engineering, member
1996 University Scholar, University of Vermont
1985 - 1990 Established Investigator of the American Heart Association
1981 - 1982, 1984 Alexander von Humboldt-Stiftung Fellowship, Universität Konstanz, West Germany
1982 Louis N. Katz Research Prize for Young Investigators, Honorable Mention (AHA)
1980 - 1981 American Heart Association Fellowship, University of Maryland
1978 - 1980 National Institutes of Health Predoctoral Fellowship, Washington University
1974 National Science Foundation Summer Fellowship, Swarthmore College


For a complete list of Mark T. Nelson's publications, please visit PubMed.
For Google Scholar Citations Profile, please visit:   Mark T. Nelson 

2015  Balbi M, Ghosh M, Longden TA, Jativa Vega M, Gesierich B, Hellal F, Lourbopoulos A, Nelson MT, Plesnila N.  Dysfunction of mouse cerebral arteries during early aging.  J Cereb Blood Flow Metab.  doi:  10.1038/jcbfm.2015.107.  PMID:  26058694

2015  Collier DM, Hill-Eubanks DC, Nelson MT.  Orchestrating Ca2+ influx through CaV1.2 and CaV3.x channels in human cerebral arteries.  J Gen Physiol.  doi:  10.1085/jgp.201511411.  PMID:  26009543, PMCID:  PMC4442783

2015 Joutel A, Haddad I, Ratelade J, Nelson MT.  Perturbations of the cerebrovascular matrisome:  a convergent mechanism in small vessel disease of the brain?  J Cereb Blood Flow Metab.  doi:  10.1038/jcbfm.2015.62.  PMID:  25853907, PMCID:  PMC4442783

2015  Dabertrand F, Kroigaard C, Bonev AD, Cognat E, Dalsgaard T, Domenga-Denier V, Hill-Eubanks DC, Brayden JE, Joutel A, Nelson MT.  Potassium channelopathy-like defect underlies early-stage cerebrovascular dysfunction in a genetic model of small vessel disease.  Proc Natl Acad Sci USA. doi:  10.1073/pnas.1420765112.  PMID:  25646445, PMCID:  PMC4343103

2015  Longden TA, Nelson MT.  Vascular Inward Rectifier K+ Channels as External K+ Sensors in the Control of Cerebral Blood Flow.  Microcirculation.  doi:  10.1111/micc.12190.  PMID:  25641345, PMCID:  PMC4404517

2014  Villalba N, Sonkusare SK, Longden TA, Tran TL, Sackheim AM, Nelson MT, Wellman GC, Freeman K.  Traumatic brain injury disrupts cerebrovascular tone through endothelial inducible nitric oxide synthase expression and nitric oxide gain of function.  J Am Heart Assoc.  doi:  10.1161/JAHA.114.001474.  PMID:  25527626, PMCID:  PMC4338739

2014  Longden TA, Hammack SE, Nelson MT.  Channeling Stress:  inwardly-rectifying K+ channels in stress and disease,  Channels (Austin).  PMID:  2548622

2014  Hill-Eubanks DC, Gonzales AL, Sonkusare SK, Nelson MT.  Vascular TRP Channels:  Performing Under Pressure and Going with the Flow.  Physiol Rev. doi:  10.1152/physiol.00009.2014.  PMID:  25180264, PMCID:  PMC4214829

2014  Mingin GC, Peterson A, Erickson CS, Nelson MT, Vizzard MA.  Social stress induces changes in urinary bladder function, bladder NGF content and generalized bladder inflammation in mice.  Am J Physiol Regul Integr Comp Physiol.  doi:  101152/ajpregu.00500.2013.  PMID:  25100077, PMCID:  PMC4187184

2014  Sonkusare SK, Dalsgaard T, Bonev AD, Hill-Eubanks DC, Kolikoff MI, Scott JD, Santana LF, Nelson MT.  AKAP150-dependent cooperative TRPV4 channel gating is central to endothelium-dependent vasodilation and is disrupted in hypertension.  Science Signaling.  doi:  10.1126/scisignal.2005052.  PMID:  25005230, PMCID:  PMC4403000.  Journal Cover, with Perspective:  Pooneh B, Garland CJ, Scaffolding Builds to Reduce Blood Pressure, Science Signaling 2014 July.  doi:  10.1126/scisignal.2005527

2014  Nausch B, Rode F, Jorgensen S, Nardi A, Korsgaard MP, Hougaard C, Brown WD, Bonev AD, Dyhring T, Strobaek D, Olesen SP, Christophersen P, Grunnet M, Nelson MT, Ronn LC.  NS19504:  a novel BK channel activator with relaxing effect on bladder smooth muscle spontaneous phasic contractions.  J Pharmacol Exp Ther.  doi:  10.1124/jpet.113.212662.  PMID:  24951278, PMCID:  PMC4152884

2014  Gonsales AL, Yang Y, Sullivan MN, Sanders L.  Dabertrand F, Hill-Eubanks DC, Nelson MT, Earley S.  A PLCy1-Dependent, Force-Sensitive Signaling Network in the Myogenic Constriction of Cerebral Arteries.  Science Signaling.  doi:  10.1126/scisignal.200732.  PMID:  24866019, PMCID:  PMC4170587

2014  Longden TA, Dabertrand F, Hill-Eubanks DC, Hammack SE, Nelson MT.  Stress-induced glucocorticoid signaling remodels neurovascular coupling through impairment of cerebrovascular inwardly rectifying K+ channel function.  Proc Natl Acad Sci USA.  doi:  10.1073/pnas.1401811111.  PMID:  24808139, PMCID:  PMC4034203

2014  Mercado J, Baylie R, Navedo MF, Yuan C, Scott JD, Nelson MT, Brayden JE, Santana LF.  Local control of TRPV4 channels by AKAP150-targeted PKC in arterial smooth muscle.  J Gen Physiol.  doi:  10.1085/jgp.201311050.  PMID:  24778429, PMCID:  PMC4003184

2014  Krishnamoorthy G, Sonkusare SK, Heppner TJ, Nelson MT.  Opposing roles of smooth muscle BK channels and ryanodine receptors in the regulation of nerve-evoked constriction of mesenteric resistance arteries.  Am J Physiol Heart Circ Physiol.  doi:  10.1152/ajpheart.00866.2013.  PMID:  24508642, PMCID:  PMC3962638