NIMH R01 MH098073 - 9/1/12 – 8/31/16
Agency: National Institute of Health
Annual Direct Costs: $518,331
“Risk and Resilience in Maltreated Children”
This investigation represents a study within a study; one that will provide rich data for the Research
Domain Criteria (RDoC) project; and one that will also provide invaluable data on risk and resilience in maltreated children. This application delineates plans to examine the RDoC domain Negative Valence Systems, or more specifically, acute threat - “fear;” and proposes to collect data on multiple units of analysis included in the RDoC matrix: genes, circuits, and self-reports of clinical symptoms.
Role: PI (MPI Project)
NIMH 1R01 DK092127 - 9/30/10-8/31/2015
Agency: National Institute of Health
Annual Direct Costs: $2,377,655
“Determinants of Adolescent Exercise Behavior: Towards Evidence-Based Intervention”
This application proposes a combined survey, laboratory, and intervention study using the unique data
collection in the Netherlands Twin Register (NTR) with longitudinal assessment of exercise behavior and many of its potential (environmental) moderators at ages 7, 9, 12, 14, 16, and 18. It aims to determine the causes of individual differences in voluntary exercise behavior from childhood to young adulthood and use this information to develop a novel family-based E-intervention program to change exercise behavior in young adolescents.
NIMH. 1K08MH082116 7/09-7/14
“Child Behavior Checklist-Dysregulation Profile: Genes, Environment, and Life Course”
This proposal describes a 5 year mentored training program to develop a research career in child and Adolescent Psychiatry; Research will focuus on the CBCL-Dysregulation Profiles as a masure of mood instability, attention problesm, and aggression that is often seen in child and adoelscent pscyhiatry clinics, but poorly studies and understood.
Klingenstein Third Generation Foundation, “Donald J. Cohen Medical Student Training Program”
Goals of the program are 1) to crea Donald J. Cohen Medical Student Training Program”
1)positive mentoring relationships between medical students and child psychiatrists,
2)to teach empirically-based and family-centered assessment, and
3) to encourage students to consider a career in child and adolescent psychiatry.
ZonMw TOP (Projectleider en penvoerder):
03/1/2010 – 2/28/2017 € 675,000
Project title: “The Neurobiology and developmental trajectories in Children at Risk for Severe Psychopathology.”
PI: Tonya White, PhD, MD
National Healthcare Group (NHG) - Singapore SIG 1 - 04/01/12-03/31/2014
“Patterns Of Mood And Anxiety Disorders In Parents Of Clinically Referred Children: Laying The Foundation For A
Family-Based Approach To Mental Health In Singapore”
The primary aim of this study is to characterize patterns of psychiatric diagnosis and mental health problems
among the parents of clinically-referred youth with mood and anxiety disorders in Singapore.
PI: Dr. Sharon Cohan Sung
Role: Foreign Collaborator
PENDING RESEARCH – In Review:
NIMH AN:3490882 - 04/1/13-03/31/18 1.2 Cal
Agency: National Institute of Health $ 7,172,443
“Epigenetics, MRI, and Phenotypic Correlates of Child Development”
In this proposal we will explore epigenetic mechanisms and their influence on child health outcomes using a p
rospective design with detailed measurements about fetal and infant exposures, early childhood exposures, and
biological samples for measuring DNA Methylation patterns, expression, GWAS, exome sequencing,
blood-buccal across tissue epigenetics, and detailed phenotype assessments in childhood and later life.
Visscher P, Franic S, Boomsma DI, Hudziak JJ. The Childhood Intelligence Consortium (CHIC). Childhood intelligence is heritable, highly polygeneic and associated with FNBP1L.-in preparation.
Abdellaoui A, Hottenga JJ, de Knijff P, Nivard MG, Xiao X, Scheet P, Brooks A, Ehli EA, Yueshan H, Davies GE, Hudziak JJ, Sullivan P, van Beijsterveldt T, Willemsen G, de Geus EJ, Penninx BWJH, Boomsma DI. Population Structure, Migration, and Diversifying Selection in the Netherlands. Genome Research-In review.
Groen-Blokhuis MM, Franic S, van Beijsterveldt CEM, de Geus E, Davies GE, Ehli E, Xiao X, Scheet P, Bartels M, Althoff R, Hudziak JJ, Middeldorp CM, Boomsma DI. A prospective study of the effects of breastfeeding and FADS2 polymorphisms on cognition and attention problems. PNAS-In review .
Albaugh MD, Ducharme S, Karama S, Althoff RR, Botteron KN, Evans AC, Hudziak JJ, and the Brain Development Cooperative Group. Subclinical anxious-depressed problems qualify the relation between ventral cingulate cortical thickness and normative aggression in healthy youths. Cerebral Cortex-In review.
Baer J, Althoff RR, Rettew DC, Harder VS, Ayer LA, Albaugh MD, Kuny AV, Hudziak JJ, Associations Among Child Temperament, Parenting Behavior, and Child Social Functioning as Measured by the Child Behavior Checklist. J Clin Child Adolesc Psychol-In review.
Ayer LA, Jansen PW, Hudziak JJ, Jaddoe VWV, Hofman A, Verhulst FC, & Tiemeier H. Intergenerational effects of maternal childhood abuse: Mechanisms of risk transmission. Development and Psychopathology-In review.
Franic S,Dolan CV, Borsboom, D, Hudziak JJ, van Beijsterveldt CEM, Boomsma DI, Can Genetics Help Psychometrics? Improving Dimensionality Assessment through Genetic Factor Modeling. Psychological Methods-In review.
Kuny AV, Althoff RR, Copeland W, Bartels M, Van Beijsterveldt CE, Baer J, Hudziak JJ. Separating the domains of oppositional behavior: comparing latent models of the conners’ oppositional subscale. J Am Acad Child Adolesc Psychiatry. 2013 Feb;52(2): 172-183 PMID: 23357444.
Benyamin B, Pourcain B, Davis OS, Davies G, Hansell NK, Brion MJ, Kirkpatrick RM, Cents RA, Franic S, Miller MB, Haworth CM, Meaburn E, Price TS, Evans DM, Timpson N, Kemp J, Ring S, McArdle W, Medland SE, Yang J, Harris SE, Liewald DC, Scheet P, Xiao X, Hudziak JJ, de Geus EJ, Wellcome Trust Case Control Consortium 2 (WTCCC2), Jaddoe VW, Starr JM, Verhulst FC, Pennell C, Tiemeier H, Iacono WG, Palmer LJ, Montgomery GW, Martin NG, Boomsma DI, Posthuma D, McGue M, Wright MJ, Davey Smith G, Deary IJ, Plomin R, Visscher PM. Childhood intelligence is heritable, highly polygenic and associated with FNBP1L. Mol Psychiatry. 2013 Jan 29 (Epub ahead of
print]. PMID: 23358156
Albaugh MD, Ducharme S, Collins DL, Botteron KN, Althoff RR, Evans AC, Karama S. Hudziak JJ, for the Brain Development Cooperative Group. Evidence for a cerebral cortical thickness network anti-correlated with amygdalar volume in healthy youths: implications for the neural substrates of emotion regulation. Neuroimage. 2013 Jan 9 [Epub ahead of print]. PMID 23313419
Hudziak JJ, Novins DK. Illuminating the Complexities of Developmental Psychopathology: Special Series on Longitudinal and Birth Cohort Studies. J Am Acad Child Adolesc Psychiatry. 2013 Jan,52(1). PMID: 23265628.
Tharner A, Dierckx B, Luijk M, van IJzendoorn M, Bakermans-Kranenbeurg M, van Ginkel JR, Moll HA, Jaddoe VWV, Hofman A, Hudziak JJ, Verhulst FC, Tiemeier H. Attachment disorganization moderates the effect of maternal postnatal depressive symptoms on infant autonomic functioning. Psychophysiology 2012 Dec 18 [Epub ahead of print]. PMID: 23252764.
Greaves-Lord K, Eussen M, Verhulst F, Minderaa R, Mandy W, Hudziak J, Steenhuis MP, de Nijs P, Hartman C. Empirically based phenotypic profiles of children with Pervasive Developmental Disorders: interpretation in the light of the DSM-5. Autism, December 8, 2012.
Van Beijsterveldt CE, Groen-Blokhuis M, Hottenga JJ, Franic S, Hudziak JJ, Lamb D, Huppertz C, de Zeeuw E, Nivard M, Schutte N, Swagerman S, Glasner T, van Fulpen M, Brouwer C, Stroet T, Nowotny D, Ehli EA, Davis GE, Scheet P, Orlebeke JF, Kan KJ, Smit D, Dolan CV, Middeldorp CM, de Geus EJ, Bartels M, Boomsma DI. The Young Netherlands Twin Register (YNTR): Longitudinal Twin and Family Studies in Over 70,000 Children. Twin Res Hum Genet. 2012 Nov 28:1-16 [Epub ahead of print.
Tiemeier H, Velders FP, Szekely E, Roza SJ, Dieleman G, Jaddoe VWV, Uitterlinden AG, White TJH, Bakersmans-Kranenburg MJ, Hofman A, Van IJzendoorn HV, Hudziak J, Verhulst FC. The Generation R Study: A Review of Design, Findings to Date and a Study of the 5-HTTLPR by Environment Interaction From Fetal Life Onwards. J Can Acad Child Adolesc Psychiatry 2012 Nov;51(11):119-1135. PMID: 23101739.
Scheet P, Ehli EA, Xiao X, van Beijsterveldt CE, Abdellaoui A, Althoff RR, Hottenga JJ, Willemsen G, Nelson KA, Huizenga PE, Hu Y, Amos CI, Bartels M, Groen-Blokhuis MM, de Geus EJ, Hudziak JJ, Davies GE, Boomsma DI. Twins, Tissue, and Time: An Assessment of SNPs and CNVs. Twin Res Hum Genet. 2012 Sep 28:1-9. PMID: 23021707.Rubin D, Althoff RR, Walkup JT, Hudziak JJ. Cross-informant Agreement on Child and Adolescent Withdrawn Behavior: A Latent Class Approach. Child Psychiatry Hum Dev, 2012 Sept published online. PMID: 22968799.
Verlinden M, Tiemeier H, Hudziak JJ, Jaddoe VW, Raat H, Guxens M, Hofman A, Verhulst FC, Jansen PW. Television Viewing and Externalizing Problems in Preschool Children: The Generation R Study. Arch Pediatr Adolesc Med. 2012 Aug 6:1-7. PMID 22869354.
Huppertz C, Bartels M, van Beijsterveldt CE, Boomsma DI, Hudziak JJ, de Geus EJ. Effects of Shared Environmental Factors on Exercise Behavior from Age 7 to 12. Med Sci Sports Exerc. 2012 Oct, 44(10):2025-32. PMID: 22617397 NIHMS385418.
Ehli EA, Abdellaoui A, Hu Y, Hottenga JJ, Kattenberg M, van Beijsterveldt CEM, Bartels M, Althoff RR, Xiao XJ, Scheet P, de Geus EJ, Hudziak JJ, Boomsma DI, Davies GE. De novo and inherited CNVs in MZ twin pairs selected for discordance and concordance on Attention Problems. European Journal of Human Genetics, April 2012 [Epub ahead of print]. PMID:22490988.
Cents RA, Diamantopoulous S, Hudziak JJ, Jaddoe VW, Hofman A, Verhulst FC, Lambregtse-van den Berg MP, Tiemeier H. Trajectories of maternal depressive symptoms predict child problem behavior: The Generation R Study. Psycho Med. 2012 Apr 11:1-13. [Epub ahead of print]. PMID: 22490169.
Hudziak JJ, Novins DK. Associate Editors Note. Proposed criteria for autism spectrum disorder in the DSM-5. J Am Acad Child Adolesc Psychiatry, 2012 Apr;51(4):343. PMID 22449637.
El Marroun H, Jaddoe VWV, Hudziak JJ, Roza SJ. Steegers EAP, Hofman A, Verhulst FC, White TJH, Stricker BHC, Tiemeier H, Maternal use of selective serotonin reuptake inhibitors, fetal growth and risk of adverse birth outcomes. Arch Genl Psychiatry. 2012 Jul;69(7):706-14. PMID: 22393202.
Ayer LA, Crehan ET, Rettew DC, Baer JR, Hudziak JJ. Temperamental profiles of dysregulated children. Child Psychiatry Hum Dev 2012 Aug;43(4):511-22] PMID: 22271225.
Cents RA, Tiemeier H, Velders FP, Jaddoe VWV, Hofman A, Verhulst FC, Lambregtse-van van den Berg MP, Hudziak JJ. Maternal smoking during pregnancy and child emotional problems: The relevance of maternal and child 5-HTTLPR genotype. Am J Med Genet B Neuropsychiatr Genet. 2012 Jan 18 [Epub ahead of print]. PMID: 22259195.
Ducharme S, Hudziak JJ, Botteron KN, Albaugh M, Nguyen, TV, Karama S Evans AC for the Brain Development Cooperative Group. Decreased Regional Cortical Thickness and Thinning Rate Are Associated With Inattention Symptoms in Healthy Children. J Am Acad Child Adolesc Psychiatry, 2012 January; 51(1):18-27.PMID: 22176936.
Hudziak JJ, Willemsen G, Hudziak V, Bartels M, Boomsma DI. Genetic and environmental contributions to self-reported thoughts of self-harm and suicide. Am J Med Genet B Neuropsychiatr Genet-2012 Jan;159B(1):120-7. PMCID: PMC3254180/ NIHMS346064.