University of Vermont

College of Medicine

Department of Pediatrics

Bio for James Hudziak, M.D.
James Hudziak, M.D.

James Hudziak, M.D.

Professor
Department of Psychiatry


Contact Information
E-mail: James.Hudziak@uvm.edu
Office Location:
Psychiatry, UHC St. Joseph’s Room 3213, 1 South Prospect, Burlington, VT 05401

Education

1979 B.S., St. John's University, Collegeville, Minnesota
1988 M.D., University of Minnesota, Minneapolis, Minnesota
1988-1989 Intern in Psychiatry, Washington University, St. Louis, MO
1989-1991 Resident in Psychiatry, Washington University, St. Louis, MO
1991-1993 Fellow in Child Psychiatry, Washington University, St. Louis, MO

Research Interests

Psychiatric genetics of child psychiatric disorders, application of family study, twin study, and molecular genetic techniques to the study of attention deficit disorder, anxiety and affective disorders, autism, and conduct disorder.

Academic Appointments

2012-2017: Graduate Faculty Status, Division of Basic Biomedical Sciences in The Sanford School of Medicine at the University of South Dakota, SD
2012-Present: Adjunct Professor, Child Psychiatry, Washington University, St. Louis, MO
2009-Present: Visiting Professor, Erasmus University, Sophia Childrens Hospital, Rotterdam, The Netherlands
2007-Present: Thomas M. Achenbach Chair in Developmental Psychopathology
2006-Present: Professor of Pediatrics, Department of Pediatrics, University of Vermont, College of Medicine, Burlington, VT
2005-Present: Professor of Child Psychiatry, Department of Psychiatry, University of Vermont, College of Medicine, and Fletcher Allen Health Care, Burlington, VT
2005-Present: Professor of Medicine, Department of Medicine, University of Vermont, College of Medicine (Human Medical Genetics), Burlington, VT
1996-Present: Research Director, Pediatric Psychopharmacology, Department of Psychiatry, University of Vermont, College of Medicine, Burlington, VT
1996-Present: Adjunct Professor of Psychiatry, Dartmouth Medical School, Hanover, NH
2005-2012: Special Professor, Genetics of Childhood Behavior Problems, Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands
2005-2009: Director, Child Psychiatry, Department of Psychiatry, University of Vermont, College of Medicine, Burlington, VT
1997-2009: Director, Division of Behavioral Genetics, University of Vermont, College of Medicine, Burlington, VT
1994-2001: IRB (Institutional Review Boards), University of Vermont, Burlington, VT
1994-1999: Director, Medical Student Training in Clinical Psychiatry, University of Vermont College of Medicine, Burlington, VT
1994-1999: Course Master, Introduction to Psychopathology, University of Vermont, College of Medicine, Burlington, VT
1994-1997: Associate Residency Director of Psychiatry, University of Vermont, College of Medicine, Burlington, VT
1993-1997: Director Pediatric Psychopharmacology Clinic, Department of Psychiatry, University of Vermont College of Medicine, Burlington, VT

Research Grants

FUNDED RESEARCH:

NIMH R01 MH098073 - 9/1/12 – 8/31/16      
Agency: National Institute of Health   
Annual Direct Costs: $518,331
“Risk and Resilience in Maltreated Children”           
This investigation represents a study within a study; one that will provide rich data for the Research
Domain Criteria (RDoC) project; and one that will also provide invaluable data on risk and resilience in maltreated children. This application delineates plans to examine the RDoC domain Negative Valence Systems, or more specifically, acute threat - “fear;” and proposes to collect data on multiple units of analysis included in the RDoC matrix: genes, circuits, and self-reports of clinical symptoms.                      
Role: PI (MPI Project)   

NIMH 1R01 DK092127 - 9/30/10-8/31/2015
Agency: National Institute of Health
Annual Direct Costs: $2,377,655
“Determinants of Adolescent Exercise Behavior: Towards Evidence-Based Intervention”
This application proposes a combined survey, laboratory, and intervention study using the unique data
collection in the Netherlands Twin Register (NTR) with longitudinal assessment of exercise behavior and many of its potential (environmental) moderators at ages 7, 9, 12, 14, 16, and 18. It aims to determine the causes of individual differences in voluntary exercise behavior from childhood to young adulthood and use this information to develop a novel family-based E-intervention program to change exercise behavior in young adolescents.
Role: PI

NIMH. 1K08MH082116 7/09-7/14
“Child Behavior Checklist-Dysregulation Profile: Genes, Environment, and Life Course”
This proposal describes a 5 year mentored training program to develop a research career in child and Adolescent Psychiatry; Research will focuus on the CBCL-Dysregulation Profiles as a masure of mood instability, attention problesm, and aggression that is often seen in child and adoelscent pscyhiatry clinics, but poorly studies and understood.
Role: Mentor

Klingenstein Third Generation Foundation, “Donald J. Cohen Medical Student Training Program”         
7/1/11-6/30/14 
Goals of the program are 1) to crea Donald J. Cohen Medical Student Training Program”
1)positive mentoring relationships between medical students and child psychiatrists,
2)to teach empirically-based and family-centered assessment, and
3) to encourage students to consider a career in child and adolescent psychiatry.   
Role: Mentor

ZonMw TOP (Projectleider en penvoerder): 
03/1/2010 – 2/28/2017        € 675,000
Project title: “The Neurobiology and developmental trajectories in Children at Risk for Severe Psychopathology.”  
PI: Tonya White, PhD, MD   
Role: Co-Investigator

National Healthcare Group (NHG) - Singapore SIG 1 - 04/01/12-03/31/2014
“Patterns Of Mood And Anxiety Disorders In Parents Of Clinically Referred Children: Laying The Foundation For A
Family-Based Approach To Mental Health In Singapore”
The primary aim of this study is to characterize patterns of psychiatric diagnosis and mental health problems
among the parents of clinically-referred youth with mood and anxiety disorders in Singapore.
PI: Dr. Sharon Cohan Sung       
Role: Foreign Collaborator

PENDING RESEARCH  –  In Review:

NIMH AN:3490882 - 04/1/13-03/31/18        1.2 Cal 
Agency: National Institute of Health   $ 7,172,443
 “Epigenetics, MRI, and Phenotypic Correlates of Child Development”
In this proposal we will explore epigenetic mechanisms and their influence on child health outcomes using a p
rospective design with detailed measurements about fetal and infant exposures, early childhood exposures, and
biological samples for measuring DNA Methylation patterns, expression, GWAS, exome sequencing,
blood-buccal across tissue epigenetics, and detailed phenotype assessments in childhood and later life.   
Role: PI

Awards and Honors

1990-1991 Resident Representative to the Eastern Missouri Psychiatric Society
1990-1992 Burroughs-Wellcome (Falk) Fellowship
1998 J. Macy Foundation, the Implication of Genetics for Health Professional Education, New Mexico
2001 J. Macy Foundation, the Future of Psychiatry in Medical Education, Toronto, Canada
2002 Psychiatry Residents Teacher of the Year Award, University of Vermont; Burlington, VT
2002-2003 Institute Of Medicine Committee on Incorporating Research into Psychiatry Residency Training, Washington DC
2002 Psychiatry Residents Teacher of the Year Award, University of Vermont, Burlington, VT
2007 Genetic and Environmental Influences on Child Psychopathology and Wellness, UCLA, Greenblatt Professorship Lecture, Los Angeles, CA
2009 Charlotte Brewster Lecturer, University of Colorado Denver School of Medicine
2009 Guide to America’s Top Psychiatrists
2010 American Registry, America’s Top Doctors, Castle Connolly Medical Ltd.
2006 Class of 2008 Foundations Awards; The Silver Stethoscope Award
2007 Class of 2009 Foundations Awards; The Silver Stethoscope Award
2008 Class of 2010 Foundations Awards; The Silver Stethoscope Award
2009 Class of 2011 Foundations Award; Nomination for The Silver Stethoscope Award
2010 Class of 2012 Foundations Award; Nomination for The Silver Stethoscope Award
2011 Class of 2013 Foundations Award; Nomination for The Silver Stethoscope Award
2010-2011 2010 University Scholar Award, University of Vermont, Burlington, VT
1998-present The Best Doctors in America, Woodward/White, Inc.
2004-present Marquis Whos Who American in Medicine and Healthcare
2008-present America’s Top Doctors
2011 Distinguished Fellow of the American Academy of Child & Adolescent Psychiatry, AACAP Annual Meeting's
2011-Present: Annual New York in US News and World Report Top 1% Doctors in US from Vermont and Northern

Publications

Link to Publications
Ameis S, Ducharme S, Albaugh MD, Hudziak JJ, Botteron KN, Lepage C, Zhao L, Khundrakpam B, Collins DL, Lerch JP, Wheeler A, Schachar R, Evans AC, and Karama S. Cortical Thickness, Cortico-Amygdalar Networks, and Externalizing Behaviors In Healthy Children. Biological Psychiatry 2013. Rubin DH, Althoff RR, Ehli EA, Davies GE, Rettew DC, Crehan ET, Walku JT, Hudziak JJ.Candidate gene assoications with withdrawn behavior. J Child Psychol Psychiatry. 2013 June 28 [Epub ahead of print]. PMID: 23808549.

Ducharme S, Albaugh MD, Hudziak JJ, Botteron KN, Tuong-Vi N, Truong C, Evans AC, Karama S, For the Brain Development Cooperative Group. Anxious/Depressed Symptoms are Linked to Right Ventromedial Prefrontal Cortical Thickness Matuation in Healthy Children and Young Adults. Cerebral Cortex Advance Assess, June 2013.

Franic S, Dolan CV, Borsboom, Hudziak JJ, van Beijsterveldt CEM, Boomsma DI. Can Genetics Help Psychometrics? Improving Dimensionality Assessment Through Genetic Factor Modeling. Psychological Methods, 2013 Jul 8 [Epub ahead of print]. PMID: 23834420.

Groen-Blokhuis MM, Franic S, van Beijsterveldt CEM, de Geus E, Davies GE, Ehli E, Xiao X, Scheet P, Althoff R, Hudziak JJ, Middeldorp CM, Boomsma DI. A Prospective Study of the Effects of Breastfeeding and FADS2 Polymorphisms on Cognition and Hyperactivity/attention Problems. Am J Med Genet B Neuropsychiatr Genet, 2013 June 4 [Epub ahead of print]./p>