University of Vermont

College of Medicine

Department of Pediatrics

Bio for C. Lawrence Kien, M.D., Ph.D.
C. Lawrence Kien, M.D., Ph.D.

C. Lawrence Kien, M.D., Ph.D.

Professor
Department of Pediatrics
Department of Medicine
Division of Endocrinology


Contact Information
E-mail: CL.Kien@uvm.edu
Office Location:
UVM Colchester Research Facility, 360 South Park Drive, Colchester, VT 05446

Education

Ph.D., Nutritional Biochemistry and Metabolism, MIT, Cambridge, MA (1977)
M.D., University of Cincinnati College of Medicine, Cincinnati, OH (1972)
B.S. in Zoology, Duke University, Durham, NC (1968)

Academic Interests

Research: Effects of long and short chain fatty acids on metabolism and on risks of obesity and type 2 diabetes.
Teaching: Clinical nutrition deficiences, obesity, type 2 diabetes, roles of the colon in human nutrition.

Academic Appointments

Professor, Departments of Pediatrics and Medicine, University of Vermont College of Medicine, Burlington, VT (2004-present)
The Mary Kay Davignon Green and Gold Professor, University of Vermont College of Medicine (2005-present)

Research Grants

Current funding:
Palmitate metabolism and insulin resistance (C.L. Kien, PI)
     04/01/2010-12/31/2015; NIDDK

Examining the effects of consuming a diet comprising of milk fat-containing dairy products on metabolic health markers (J. Kraft, PI; C.L. Kien, Co-I)
     04/01/2013-12/31/2014; Dairy Research Institute

Dietary saturated and monounsaturated fatty acids and cognition (J.A. Dumas and C.L. Kien, Co-PIs)
     03/01/2014-02/28/2016; University of Vermont Center on Aging

Recent funding:
Mechanisms for differential effects of dietary fatty acids on metabolism (C.L. Kien, PI)
     04/13/2007-03/31/2012; NIDDK

Awards and Honors

Clinical and Integrative Diabetes and Obesity (CIDO) Study Section (Regular Member) (07/01/2007 - 06/30/2011)
National Board of Medical Examiners (NBME)
Biochemistry Test Committee, National Board of Medical Examiners (NBME) (1998-2002)
Step 1 Test Material Development Committee for Biochemistry United States Medical Licensing Examination (USMLE) (1998-2002)
Consultant (for Carbohydrates) Term Panel, Life Sciences Research Office (FASEB), (Advisory to FDA) (1996 - 2001)
Ad Hoc Expert Panel: Review of infant formula nutrient requirements for preterm infants, Life Sciences Research Office (FASEB), (Advisory to FDA)
Ad Hoc Review of the USMLE Step 1 Pass/Fall Standard (April, 2000)
Nutrition Study Section (1989 - 1993)
Special Fellow, Leukemia Society of America, Inc. (1981)
Future Leaders Award, The Nutrition Foundation, Inc. (1980)

Publications (Peer Reviewed)

Kien CL, Bunn JY, Stevens R, Bain J, Ikayeva O, Crain K, Koves TR, Muoio DM.  Dietary intake of palmitate and oleate has broad impact on systemic and tissue lipid profiles in humans.  Am J Clin Nutr 2014;99:436-445 (PMID: 24429541; available 2015/3/1).

Kien CL, Bunn JY, Poynter ME, Stevens R, Bain J, Ikayeva O, Fukagawa NK, Champagne CM, Crain KI, Koves TR, Muoio DM.  A lipidomics analysis of the relationship between dietary fatty acid composition and insulin sensitivity in young adults.  Diabetes 2013;62:1054-63 (PMID: 23238293). 

Koves TR, Sparks LM, Kovalik JP, Mosedale M, Arumugam R, DeBalsi KL, Everingham K, Thorne L, Phielix E, Meex RC, Kien CL, Hesselink MKC, Schrauwen P, Muoio DM.  PPARgamma coactivator-1alpha contributes to exercise-induced regulation of intramuscular lipid droplet programming in mice and humans.  J Lipid Res 2013;54:522-34 (PMID: 23175776).

Kien CL, Bunn J, Tompkins CL, Dumas JA, Crain KI, Ebenstein DB, Koves TR, Muoio DM.  Substituting dietary monounsaturated fat for saturated fat is associated with increased daily physical activity and resting energy expenditure and with changes in mood.  Am J Clin Nutr 2013;97:689-97 (PMID: 23446891).

Kien CL, Everingham KI, D Stevens R, Fukagawa NK, Muoio DM: Short-term effects of dietary fatty acids on muscle lipid composition and serum acylcarnitine profile in human subjects.  Obesity (Silver Spring) 2011;19:305-11 (PMID: 20559306). 

Kovalik JP, Slentz D, Stevens RD, Kraus WE, Houmard JA, Nicoll JB, Lea-Currie YR, Everingham K, Kien CL, Buehrer BM, Muoio DM.  Metabolic remodeling of human skeletal myocytes by cocultured adipocytes depends on the lipolytic state of the system.  Diabetes 2011;60:1882-93 (PMID: 21602515). 

Kien CL, Bunn JY:  Gender alters the effects of palmitate and oleate on fat oxidation and energy expenditure.  Obesity 2008;16:19-33 (PMID: 18223608). 

Kien CL, Blauwiekel R, Bunn JY, Jetton TL, Frankel WL, Holst JJ: Cecal infusion of butyrate increases intestinal cell proliferation in piglets. J Nutr 2007;137:916–22 (PMID: 17374654).

Børsheim E, Kien CL, Pearl W: Differential effects of dietary intake of palmitic acid and oleic acid on oxygen consumption during and after exercise.  Metabolism 2006;55:1215-21 (PMID: 16919541).

Kien CL, Bunn JY, Ugrasbul F: Increasing dietary palmitic acid decreases fat oxidation and daily energy expenditure. Am J Clin Nutr 2005;82:320-6 (PMID: 16087974).


For a complete list of Dr. Kien's publications, please visit Pub Med.