University of Vermont

College of Medicine

Department of Pathology and Laboratory Medicine

Bio for Mark Allegretta, Ph.D.
Mark Allegretta, Ph.D.

Mark Allegretta, Ph.D.

Assistant Professor, Department of Pathology & Laboratory Medicine

Contact Information
Office Location:
655 Spear St. Building C


1980 Hartwick College, Oneonta, NY, BA; Biology
1990 PhD, University of Vermont, Cellular and Molecular Biology Program
1990 - 1994 Stanford University,  Department of Neurology, Post-doctoral training fellow

Research Interests

Our focus is on cancer biomarker discovery, assay development and validation.  We study the role of the Glypican-3 (GPC3) biomarker in hepatocellular carcinoma.  Additional biomarkers for colon, ovarian and breast cancer are in development, as are novel tests for somatic mutation for use as tools in genetic toxicology.

Academic Appointments

2000 - Present, Research Assistant Professor, Dept. of Pathology, Univ. of Vermont
1998 - Present Chief Scientific Officer, BioMosaics, Inc., Burlington, VT
1998 Associate Director of Immunology, InterMune Pharmaceuticals, Inc., Palo Alto, CA
1994 - 1998 Scientist, Program Leader, Connetics Corporation, Palo Alto, CA

Awards and Honors

1994 Stanford Immunology Program Postdoctoral Fellowship
1990 - 1993 National Multiple Sclerosis Society Post-doctoral Scholarship; Stanford University


2011 Allegretta M, Filmus J. Therapeutic potential of targeting glypican-3 in hepatocellular carcinoma. Anticancer Agents Med Chem. 2011 Jul 1;11(6):543-8.
2009 Kandil D, Leiman G, Allegretta M, Evans M. Glypican-3 protein expression in primary and metastatic melanoma: a combined Immunohistochemistry and Immunocytochemistry study. Cancer  Aug 25;117(4):271-8.
2007 Kandil D, Leiman G, Allegretta M, Trotman W, Pantanowitz L, Goulart R, Evans MF. Glypican-3 immunocytochemistry in liver fine-needle aspirates: a novel stain to assist in the differentiation of benign and malignant liver lesions. Cancer. 2007;111:316-22.
2006 Wang, X. Y., Degos, F., Dubois, S., Tessiore, S., Allegretta, M., Guttmann, R. D., Jothy, S., Belghiti, J., Bedossa, P., and Paradis, V. Glypican-3 expression in hepatocellular tumors: diagnostic value for pre-neoplastic lesions and hepatocellular carcinomas. Hum Pathol, :1435-1441, 2006.
2005 Allegretta, M., Ardell, S. K., Sullivan, L. M., Jacobson, S., Mortreux, F., Wattel, E., and Albertini, R. J. HPRT mutations, TCR gene rearrangements and HTLV-1 integration sites define in vivo T cell clonal lineages. Environ Mol Mutagen, Mar-Apr;45 (2-3):  326-37, 2005.
For a complete list of Mark Allegretta's publications, please visit PubMed.