University of Vermont

College of Medicine

Department of Obstetrics, Gynecology & Reproductive Sciences

Bio for Mark Phillippe, M.D., MHCM
Mark Phillippe, M.D., MHCM

Mark Phillippe, M.D., MHCM

Professor
Department of Obstetrics, Gynecology and Reproductive Sciences


Contact Information
E-mail: Mark.Phillippe@uvm.edu
Office Location:
Professor, Obstetrics and Gynecology, MFU, Smith 410, Burlington, VT 05401

Education

B.S. - Northwestern University, Evanston, IL (1971)
M.D. - Northwestern University Medical School, Chicago, IL (1974)
M.S. HCM - Harvard School of Public Health, Boston, MA (2007)

Research Interests

The goal of Dr. Phillippe's research has been to elucidate the mechanisms underlying preterm delivery occurring in the presence of intrauterine inflammation, infection and hemorrhage.  More recently, Dr. Phillippe's research has addressed the pathophysiologic mechanisms responsible for the increased maternal morbidity, mortality and pregnancy loss rate (i.e. spontaneous abortion and preterm delivery) in the presence of severe influenza infection, as occurs with pandemic influenza.  Dr. Phillippe utilizes in vivo timed-pregnant mouse models to assess inflammation-induced gene expression, innate immunity and TLR signaling in an effort to clarify the pathophysiology of severe influenza infection during pregnancy.

Awards and Honors

Invited Speaker for the Leonard E. Safon Lectureship in Clinical Obstetrics (2008), Department of Obstetrics & Gynecology, Brigham and Women’s Hospital, Boston, MA.

Recipient of the William Heath Byford Award  (2008) from the Department of Obstetrics & Gynecology, Northwestern University Feinberg School of Medicine, Chicago, IL.

Member of the National Advisory Council for the National Institute of Child Health and Human Development (NICHD), National Institutes of Health.

Invited Speaker for the “Celebration of Life: A Lecture Honoring Mothers” guest lectureship (2010) Magee-Women’s Research Day in Reproductive Biology and Women’s Health, Magee-Women’s Hospital, University of Pittsburgh, Pittsburgh, PA.

College of CSR Reviewers, Center for Scientific Review, National Institutes of Health.

Publications

Phillippe M, Sweet LM, Engle D.  The Role of Phospholipase C?1 Tyrosine Phosphorylation During Phasic Myometrial Contractions.   Am J Obstet Gynecol  196:179.e1-7, 2007.

Diamond AK, Sweet LM, Oppenheimer KH, Bradley DF, Phillippe M.  Modulation of Monocyte Chemotactic Protein-1 Expression during Lipopolysaccharide-induced Preterm Delivery in the Pregnant Mouse.  Reproductive Sciences   14:548-559, 2007.

Bizargity P, Del Rio Guerra R, Phillippe M, Teuscher C, Bonney EA.  Resistance to Lipopolysaccharide-induced Preterm Delivery Mediated by Regulatory T Cell Function in Mice.     Biology  Reprod 80:874-881,2009.

Phillippe M, Sweet LM, Bradley DF, Engle D.  Role of Non-Receptor Protein Tyrosine Kinases During Phospholipase C-?1 Related Uterine Contractions in the Rat.  Reproductive Sciences  16:265-273, 2009.

Phillippe M, Diamond AK, Sweet LM, Oppenheimer KH, Bradley DF.  Expression of Coagulation Protein Related Genes during LPS-Induced Preterm Delivery in the Pregnant Mouse.  Reproductive Sciences   18:1071-79, 2011.