Bio for George Osol, Ph.D. George Osol, Ph.D.Professor, WRHR Program DirectorDepartment of Obstetrics, Gynecology and Reproductive Sciences Contact Information E-mail: George.Osol@uvm.eduPhone: 802-656-1203Office Location: Obstetrics, Gynecology and Reproductive Sciences, Given Room C-217A, 89 Beaumont Avenue, Burlington, VT 05405 WebsiteOsol LabEducation1981 Ph.D. - University of Vermont, Burlington, VT, Reproductive Physiology1977 M.S. - University of Vermont, Burlington, VT, Physiology1974 B.S. - Manhattan College, Bronx, NY, BiologyResearch InterestsDr. Osol’s research interest is vascular adaptation during pregnancy, and addresses the following questions: (1) What are the mechanisms that regulate maternal uterine vascular remodeling during pregnancy, and how are they altered in hypertensive pregnancy? (2) What is the role of PlGF and VEGF in mediating these processes? (3) How do physical forces such as intravascular pressure/stretch regulate resistance artery tone (myogenic behavior)? (4) What is the nature of communication/signal transfer between veins and arteries (venoarterial signaling)? The rat is the primary animal model, and some of the experimental techniques used in the lab include: in vivo surgical manipulation of the uterus and its circulation; in vivo inhibition of cell signaling (e.g. NOS inhibition, ACE inhibition, calcium channel blockade); isolated pressurized vessel myography of resistance arteries and veins; molecular analyses (RT-PCR, Western blotting, immunocytochemistry); tissue/cell imaging for morphometric analysis, e.g. TEM, SEM, confocal microscopy.Awards and Honors2011 University Scholar, University of Vermont2002 Distinguished Alumnus Award, College of Arts and Life Sciences, University of Vermont 1996, 1998, 2001, 2003 Presidential Abstract Recipient, Society for Gynecologic Investigation 1991, 1992 Recipient, American Heart Association Dedicated Service AwardPublicationsOsol G, Moore LG. Maternal uterine vascular remodeling during pregnancy. Microcirculation. 2014 Jan;21(1):38-47. doi: 10.1111/micc.12080. PubMed PMID: 23941526.Huppertz B, Meiri H, Gizurarson S, Osol G, Sammar M. Placental protein 13 (PP13): a new biological target shifting individualized risk assessment to personalized drug design combating pre-eclampsia. Hum Reprod Update. 2013 Jul-Aug;19(4):391-405. doi: 10.1093/humupd/dmt003. Epub 2013 Feb 17. Review. PubMed PMID: 23420029.Gizurarson S, Huppertz B, Osol G, Skarphedinsson JO, Mandala M, Meiri H. Effects of placental protein 13 on the cardiovascular system in gravid and non-gravid rodents. Fetal Diagn Ther. 2013;33(4):257-64. doi: 10.1159/000345964. Epub 2013 Feb 8. PubMed PMID: 23406577.Osol G, Barron C, Mandalà M. Uterine distension differentially affects remodelling and distensibility of the uterine vasculature in non-pregnant rats. Reprod Fertil Dev. 2012;24(6):835-42. doi: 10.1071/RD11208. PubMed PMID: 22781934.Colton I, Mandalà M, Morton J, Davidge ST, Osol G. Influence of constriction, wall tension, smooth muscle activation and cellular deformation on rat resistance artery vasodilator reactivity. Cell Physiol Biochem. 2012;29(5-6):883-92. doi: 10.1159/000178465. Epub 2012 May 11. PubMed PMID: 22613988.See PubMed listing here.