Bio for Lucia Y. Brown, M.D. Lucia Y. Brown, M.D.Assistant ProfessorDepartment of Obstetrics, Gynecology and Reproductive Sciences Contact Information E-mail: Lucia.Brown@uvm.eduPhone: 802-656-8668Office Location: Obstetrics, Gynecology and Reproductive Sciences, Given C-263, 89 Beaumont Avenue, Burlington, VT 05405 Education1996 Fellowship - Louisiana State University, New Orleans, LA, Clinical Genetics1996 Residency - Hospital de Clinicas da Faculdade de Medicina de Marilia, Brasil1993 M.D. - Faculdade de Medicina de Marilia, Estado de Sao Paulo, BrasilResearch InterestsDr. Brown’s research interests are in the holoprosencephaly gene, Zic2 and its role in early nervous system development. Current studies with Zic2 relate to its newly discovered role in the pre-implantation blastocyst as well as in embryonic stem cells. Both transgenic and tissue culture models are currently being used to elucidate Zic2 function. A second area of research relates to the global analysis of genomic methylation and the role of genomic methylation in the developing placenta.PublicationsBrown LY, Bonney EA, Raj RS, Nielsen B, Brown S. Generalized disturbance of DNA methylation in the uterine decidua in the CBA/J x DBA/2 mouse model of pregnancy failure. Biol Reprod. 2013 Nov 21;89(5):120. doi: 10.1095/biolreprod.113.113142. Print 2013 Nov. PubMed PMID: 24108302.Brown L, Mount S, Reddy R, Slim R, Wong C, Jobanputra V, Clifford P, Merrill L, Brown S. Recurrent pregnancy loss in a woman with NLRP7 mutation: not all molar pregnancies can be easily classified as either "partial" or "complete" hydatidiform moles. Int J Gynecol Pathol. 2013 Jul;32(4):399-405. doi: 10.1097/PGP.0b013e31826cbf6a. PubMed PMID: 23722513.Wright K, Brown L, Brown G, Casson P, Brown S. Microarray assessment of methylation in individual mouse blastocyst stage embryos shows that in vitro culture may have widespread genomic effects. Hum Reprod. 2011 Sep;26(9):2576-85. doi: 10.1093/humrep/der201. Epub 2011 Jun 17. PubMed PMID: 21685140.Brown L, Brown G, Vacek P, Brown S. Aneuploidy detection in mixed DNA samples by methylation-sensitive amplification and microarray analysis. Clin Chem. 2010 May;56(5):805-13. doi: 10.1373/clinchem.2009.137877. Epub 2010 Mar 11. PubMed PMID: 20224049.Brown L, Brown S. Zic2 is expressed in pluripotent cells in the blastocyst and adult brain expression overlaps with makers of neurogenesis. Gene Expr Patterns. 2009 Jan;9(1):43-9. doi: 10.1016/j.gep.2008.08.002. Epub 2008 Aug 12. PubMed PMID: 18755297.See PubMed listing here.