Bio for Stephen A. Brown, M.D. Stephen A. Brown, M.D.Associate ProfessorDepartment of Obstetrics, Gynecology and Reproductive Sciences Contact Information E-mail: Stephen.Brown@uvm.eduPhone: 802-656-4775Office Location: Obstetrics, Gynecology and Reproductive Sciences, Given C-258A, 89 Beaumont Avenue, Burlington, VT 05405 Education1992 Fellowship - Columbia University, Molecular Genetics1990 Fellowship - Columbia University, Clinical Genetics1988 Residency - University of Chicago, Chicago, IL1984 M.D. - University of Chicago, Chicago, IL1980 B.A. - University of Chicago, Chicago, IL, MedicineResearch InterestsDr. Brown’s research is focused in several distinct areas: the first pertains to the role of the Zic2 gene in the brain malformation known as holoprosencephaly. The second pertains to patterns of differential DNA methylation in human placenta and its relevance to prenatal diagnosis of chromosomal disorders. A third area of interest relates to genomic methylation abnormalities in a mouse model of early pregnancy failure.ExpertisePrenatal DiagnosisReproductive GeneticsPublicationsKline JK, Kinney AM, Levin B, Brown SA, Hadd AG, Warburton D Intermediate CGG repeat length at the FMR1 locus is not associated with hormonal indicators of ovarian age. Menopause. 2014 Jan 13. [Epub ahead of print] PMID 22423935Brown LY, Bonney EA, Raj RS, Nielsen B, Brown S Generalized disturbance of DNA methylation in the uterine decidua in the CBA/J x DBA/2 mouse model of pregnancy failure. Biol Reprod. 2013 Nov 21;89(5):120. doi: 10.1095/biolreprod.113.113142. Print 2013 Nov. PMID 24108302Brown L, Mount S, Reddy R, Slim R, Wong C, Jobanputra V, Clifford P, Merrill L, Brown S Recurrent pregnancy loss in a woman with NLRP7 mutation: not all molar pregnancies can be easily classified as either "partial" or "complete" hydatidiform moles. Int J Gynecol Pathol. 2013 Jul;32(4):399-405. doi: 10.1097/PGP.0b013e31826cbf6a. PubMed PMID: 23722513Wright K, Brown L, Brown G, Casson P, Brown S. Microarray assessment of methylation in individual mouse blastocyst stage embryos shows that in vitro culture may have widespread genomic effects. Hum Reprod. 2011 Sep;26(9):2576-85. doi: 10.1093/humrep/der201. Epub 2011 Jun 17. PubMed PMID: 21685140Brown L, Brown G, Vacek P, Brown S. Aneuploidy detection in mixed DNA samples by methylation-sensitive amplification and microarray analysis. Clin Chem. 2010 May;56(5):805-13. doi: 10.1373/clinchem.2009.137877. Epub 2010 Mar 11. PubMed PMID: 20224049See PubMed listing here.