University of Vermont

College of Medicine

Department of Obstetrics, Gynecology & Reproductive Sciences

Bio for Stephen A. Brown, M.D.
Stephen A. Brown, M.D.

Stephen A. Brown, M.D.

Associate Professor
Department of Obstetrics, Gynecology and Reproductive Sciences


Contact Information
E-mail: Stephen.Brown@uvm.edu
Phone:
802-656-4775
Office Location:
Obstetrics, Gynecology and Reproductive Sciences, Given C-258A, 89 Beaumont Avenue, Burlington, VT 05405

Education

1992     Fellowship - Columbia University, Molecular Genetics
1990     Fellowship - Columbia University, Clinical Genetics
1988     Residency - University of Chicago, Chicago, IL
1984     M.D. -  University of Chicago, Chicago, IL
1980     B.A. - University of Chicago, Chicago, IL, Medicine

Research Interests

Dr. Brown’s research is focused in several distinct areas: the first pertains to the role of the Zic2 gene in the brain malformation known as holoprosencephaly.  The second pertains to patterns of differential DNA methylation in human placenta and its relevance to prenatal diagnosis of chromosomal disorders.  A third area of interest relates to genomic methylation abnormalities in a mouse model of early pregnancy failure.

Expertise

Prenatal Diagnosis
Reproductive Genetics

Publications

Kline JK, Kinney AM, Levin B, Brown SA, Hadd AG, Warburton D  Intermediate CGG repeat length at the FMR1 locus is not associated with hormonal indicators of ovarian age. Menopause. 2014 Jan 13. [Epub ahead of print] PMID 22423935
Brown LY, Bonney EA, Raj RS, Nielsen B, Brown S  Generalized disturbance of DNA methylation in the uterine decidua in the CBA/J x DBA/2 mouse model of pregnancy failure. Biol Reprod. 2013 Nov 21;89(5):120. doi: 10.1095/biolreprod.113.113142. Print 2013 Nov. PMID 24108302
Brown L, Mount S, Reddy R, Slim R, Wong C, Jobanputra V, Clifford P, Merrill L, Brown S  Recurrent pregnancy loss in a woman with NLRP7 mutation: not all molar pregnancies can be easily classified as either "partial" or "complete" hydatidiform moles. Int J Gynecol Pathol. 2013 Jul;32(4):399-405. doi: 10.1097/PGP.0b013e31826cbf6a. PubMed PMID: 23722513
Wright K, Brown L, Brown G, Casson P, Brown S. Microarray assessment of methylation in individual mouse blastocyst stage embryos shows that in vitro culture may have widespread genomic effects. Hum Reprod. 2011 Sep;26(9):2576-85. doi: 10.1093/humrep/der201. Epub 2011 Jun 17. PubMed PMID: 21685140
Brown L, Brown G, Vacek P, Brown S. Aneuploidy detection in mixed DNA samples by methylation-sensitive amplification and microarray analysis. Clin Chem. 2010 May;56(5):805-13. doi: 10.1373/clinchem.2009.137877. Epub 2010 Mar 11. PubMed PMID: 20224049

See PubMed listing here.