University of Vermont

College of Medicine

Department of Neurological Sciences

Bio for Rodney C Scott
Rodney C Scott

Rodney C Scott

I straddle the interface between basic and clinical science and have developed skills in both domains. This has enabled me to carry out and lead multidisciplinary research projects, with scientific findings that potentially have major clinical implications.  My research focuses on the etiology and treatment of pediatric learning disorders. I am particularly interested in distinguishing cognitive deficits due to developmental anomalies of the brain from deficits caused by epilepsy driven by abnormal development.  The clinical framework of my research is from my broad background in child neurology and, over the last decade, from my specialty in pediatric epilepsy. My laboratory combines studies in animals using single unit and oscillatory activity as markers of the network together with my work with children suffering from epilepsy. In addition, my work involves transdisciplinary collaborations with computer scientists, educators, imagers, statisticians, and electrophysiologists.


Contact Information
E-mail: Rodney.Scott@med.uvm.edu
Office Location:
95 Carrigan Drive, Stafford 118D, Burlington, VT 05405, USA

Academic Appointments

2012-Present:  Professor of Paediatric Neuroscience; UCL Institute of Child Health, London, UK
2013 – Present: Professor and Vice-Chair (Research), University of Vermont College of Medicine

Academic Interests

Relationship between epilepsy and cognitive impairment
Brain injury and status epilepticus
Role of functional connectivity in epilepsy and cognition

Awards and Honors

1987  Winner of Prankard-Jones Scholarship Project:  Availability and distribution of drugs within Zimbabwe University of Zimbabwe

2000
 Gowers' Prize - Runner up Essay:   Mesial Temporal Sclerosis - Does Antecedent Matter? International League Against Epilepsy

2002 Ronnie MacKeith Prize awarded for outstanding research by a young investigator British Paediatric Neurology Association

2003 The Céline Newman Anglo-French Award for the best paper primarily written by an applicant aged 27 to 38 on a subject related to human epilepsy published during 2001 - 2002 in a peer reviewed medical/scientific journal. Fund for Epilepsy

2007 3rd Butler invited Lectureship University of Alberta

2008 Visiting Scientist Dartmouth Medical School, USA (March to September)

2009 Inaugural Murray Bornstein Fellow Dartmouth Medical School, USA (July to September)

Board Certification

2002:  Certification in Paediatric Neurology and Child Health (Royal College of Paediatric s and Child Health)

Clinical Appointments

2002-Present:  Consultant Paediatric Epileptologist, Great Ormond Street Hospital, London, UK
2013-Present:  Child Neurologist, Fletcher Allen Healthcare

Education

1983-1988: MBChB University of Zimbabwe
1995-1999: PhD University of London

Expertise

Child Neurology
Epilepsy
Status epilepticus

Licensure

2013-present:  Medical Licensure, State of Vermont

Professional Activities

2010-Present:  Member, American Epilepsy Society
2010-Present:  Member, International League against Epilepsy
2010-Present:  Member, Society for Neuroscience

Publications

Richard, G.R., Titiz, A. Tyler, A.L., Holmes, G.L., Scott, R.C., Lenck-Santini P.P. Speed modulation of hippocampal theta frequency correlates with spatial memory performance. Hippocampus (epub ahead of print)

Kleen, J.K., Scott, R.C., Holmes, G.L., Roberts, D.W., Rundle M.M., Testorf, M. Lenck-Santini, P.P. Jobst, B.C. (2013). Hippocampal Interictal Epileptiform Activity Disrupts Cognition in Humans. Neurology: 81(1); 18-24
Martinos MM, Yoong M, de-Hann M, Scott RC. (2013). The effects of convulsive status epilepticus on early development; a prospective cohort study. Epilepsia; 54(6);1012-9

Hernan AE, Holmes GL, Isaev D, Scott RC, Isaeva E. (2012). Altered short-term plasticity in the prefrontal cortex after early life seizures. Neurobiol Dis; 50(2):120-126.

Bender AC, Natola H, Holmes GL, Scott RC, Lenck-Santini PP. (2013). Focal Scn1a knockdown induces cognitive impairment without seizures  Neurobiol Dis; [Epub ahead of print]

Martinos MM, Yoong M, Scott RC, de-Haan M. (2012) Evidence for impaired recognition memory following prolonged febrile seizures. Brain; 135(10):3153-64.

Tyler AL, Mahoney JM, Richard GR, Holmes GL, Lenck-Santini PP, Scott RC (2012). Functional network changes in hippocampal CA1 after status epilepticus predict spatial memory deficits in rats. J Neurosci; 32(33):11365-76.

Duffy B, Choy M, Riegler J, Wells JA, Scott RC, Lythgoe MF (2012). Imaging Seizure-Induced Inflammation using an Antibody Targeted Iron Oxide Contrast Agent. Neuroimage; 60(2):1149-55 

Kleen, J. K., Wu, E. X., Holmes, G. L., Scott, R. C., Lenck-Santini, P. P. (2011). Enhanced oscillatory activity in the hippocampal-prefrontal network is related to short-term memory function after early-life seizures. Journal of Neuroscience 31(43), 15397-15406

Lucas, M. M., Lenck-Santini, P. P., Holmes, G. L., Scott, R. C. (2011). Impaired cognition in rats with cortical dysplasia: additional impact of early-life seizures. Brain 134(6), 1684-1693

Pujar, S. S., Neville, B. G., Scott, R. C., Chin, R. F., North London Epilepsy Research Network, (2011). Death within 8 years after childhood convulsive status epilepticus: a population-based study. Brain; 134(10): 2819-2827

Kleen, J. K., Scott, R. C., Holmes, G. L., Lenck-Santini, P. P. (2010). Hippocampal Interictal Spikes Disrupt Cognition in Rats. Annals of Neurology;  67(2): 250-257

Chin, R. F. M., Neville, B. G. R., Scott, R. C. (2009). Treatment of community-onset childhood convulsive status epilepticus Authors' reply. Lancet Neurology;  8(2): 134-135

Chin, R. F., Neville, B. G. R., Bedford, H., Wade, A., Scott, R. C. (2006). Incidence, cause, and short-term outcome of convulsive status epilepticus in childhood: prospective population-based study. Lancet; 368(9531): 222-229

Raspall-Chaure, M., Chin, R. F., Neville, B. G., Scott, R. C. (2006). Outcome of paediatric convulsive status epilepticus: a systematic review. Lancet Neurology; 5(9): 769-779

Research Grants

BUPA Foundation: Scott RC (Co-PI), Chin RF (Co-PI), Clark C, Neville BG, Chong WK, Gillberg C. The medium term outcomes of convulsive status epilepticus in children – follow up of the NLSTEPSS cohort, £189,000: 2010-2013

Great Ormond Street Hospital Children’s Charity: Scott RC. Research Leadership Award. £130,429; 2009-2010

Great Ormond Street Hospital Children’s Charity: Scott RC. Research Leadership Award. £391,287; 2010-2013

National Institutes of Health: Scott RC (PI), Holmes GL, Lenck-Santini PP, Gimi B. Mechanisms after cognitive deficits after seizures in rats with brain malformations. $1,728,125; 2011-2016

National Institutes of Health: Holmes GL (PI), Scott RC, Lenck-Santini PP, Isaev D, Khazipov R. Mechanisms of cognitive impairment following early life seizures. $1,728,125.00; 2011-2016

National Institutes of Health: Holmes GL (PI), Scott RC, Lenck-Santini PP, Jobst BC, Roberts DW. Mechanisms of cognitive impairment in temporal lobe epilepsy. $1,728,125.00; 2011-2016

National Institutes of Health: Holmes GL (Co-PI), Baram TZ (Co-PI), Scott RC, Lenck-Santini PP, Choy M, Dube C, Obenaus A. Cognitive deficits after experimental febrile seizures- neurobiology and biomarkers. $1,728,125.00; 2011-2016.

CURE Foundation: Galanopoulou A, (PI), Moshe S, Holmes GL, Scott RC, Cloyd J. Novel therapies for infantile spasms; 2012-2016