University of Vermont

College of Medicine

Department of Neurological Sciences

Bio for Rae Nishi, Ph.D.
Rae Nishi, Ph.D.

Rae Nishi, Ph.D.

Professor
Department of Neurological Sciences
Director, Neuroscience Graduate Program


Contact Information
E-mail: Rae.Nishi@uvm.edu
Office Location:
Neurological Sciences, HSRF 406, 149 Beaumont Ave., Burlington, Vt

Website

Lab: http://www.uvm.edu/medicine/neuro/?Page=nishilab.html

Education

Ph.D., University of California, San Diego, 1980
Postdoctoral training, Harvard Medical School

Academic Interests

I am the director of three advanced graduate courses: Topics in Developmental Neurobiology (NSCI320), Neurochemistry (NSCI 323), and Being a Scientist: Responsible Conduct in Biomedical Research (NSCI 327). I also oversee small group discussions for first year medical students in the Neural Science course of the Vermont integrated Curriculum. I am very interested in promoting outreach in neuroscience to K-12 students and the public. In 2011, I was elected a member of the Dana Alliance for the Brain Initiative, a program of the Dana Foundation.

Research Interests

My research focuses on the role of nicotinic acetylcholine receptors (nAChRs) in neural development and CNS function using a multidisciplinary approach that includes molecular biology, immunohistochemistry, confocal microscopy, cell culture, transgenic mice, and chicken embryos.

Administrative Interests

I am the director of the Neuroscience Graduate Program and director of the Neuroscience, Behavior and Health Initiative at UVM.

Academic Appointments

College of Medicine Faculty Appointment:  July 1, 2001
Co-director, Summer Neurobiology Course, MBL, Woods Hole, MA 2004-2007
Assistant, Associate, and full Professor, Dept. Cell and Developmental Biology, Oregon Health Sciences University, 1986-2001

Publications

Simpson J, Keefe J and Nishi R. 2013. Differential Effects of Ret and TrkB on Axonal Branching and Survival of Parasympathetic Neurons. Dev. Neurobiol 73:45-59. Epub 2012 Jul 20. PMC in process

DeWitt J, Ochoa V, Urschitz J, Elston M, Moisyadi S, and Nishi R. 2013. Constitutively active TrkB confers an aggressive transformed phenotype in a normal neural crest derived cell line. Ocogene. [Epub ahead of print], PMC in process

Nishi R, Stubbusch J, Hulce JJ, Hruska M, Pappas A, Bravo MC, Huber LP, Bakondi B. Soltys J, Rohrer H. 2010. The cortistatin gene PSS2 rather than the somatostatin gene PSS1 is strongly expressed in developing avian autonomic neurons. J Comp Neurol. 518:839-850. PMC2919489

Hruska M, Keefe J, Wert D, Tekinay AB, Hulce JJ, IbaƱez-Tallon I, Nishi R. (2009). Prostate stem cell antigen is an endogenous lynx1-like prototoxin that antagonizes alpha7-containing nicotinic receptors and prevents programmed cell death of parasympathetic neurons. J Neurosci., 29(47):14847-54. PMID: 19940180.

Hruska M. and Nishi R. (2007). Cell-Autonomous Inhibition of a7-Containing Nicotinic Acetylcholine Receptors Prevents Death of Parasympathetic Neurons during Development. J. Neurosci. 27(43):11501-11509.

Straub J., Sholler, G. and Nishi, R. (2007). Embryonic sympathoblasts transiently express TrkB in vivo and proliferate in response to brain-derived neurotrophic factor in vitro. BMC Dev Biol. 7:10-23.
To view more of Dr. Nishi's publications, please visit PubMed.