Department of Medicine
Exploration of the Biologic Basis for Underperformance of Oral Polio and Rotavirus Vaccines in Bangladesh
Oral polio and rotavirus vaccines are significantly less effective in children living in the developing world. Tropical enteropathy, which is associated with intestinal inflammation, decreased absorption and increased permeability, may contribute substantially to oral vaccine failure in developing country settings. Other possible causes of oral vaccine underperformance include malnutrition, interference with maternal or breast milk antibodies, changes in gut microbiota, and genetic susceptibility. The primary hypothesis of Exploration of the Biologic Basis for Underperformance of Oral Polio and Rotavirus Vaccines in Bangladesh clinical trial is that tropical enteropathy decreases the effectiveness of oral polio and rotavirus vaccines in infants by disrupting gut integrity. The study will enroll 700 healthy infants born in the urban slum of Mirpur, Dhaka, Bangladesh, as well as their mothers, and employ a prospective cohort, 2×2 factorial study design.
Last modified February 23 2012 01:35 PM