University of Vermont

College of Medicine

Department of Medicine

Rheumatology and Clinical Immunology

Bio for Sheldon Cooper
Sheldon Cooper

Sheldon Cooper

Professor of Medicine, Rheumatology
Department of Medicine


Contact Information
E-mail: sheldon.cooper@uvm.edu; sheldon.cooper@uvmhealth.org
Phone:
802-656-2144
Office Location:
Rheumatology and Clinical Immunology Unit, Given Building D-301, 89 Beaumont Avenue, Burlington, VT 05405, USA

Education

1963 B.S. cum laude, Hobart College, Geneva, New York
1967 M.D. New York University School of Medicine, New York, New York

Research Interests

Dr. Cooper’s research is focused on understanding the pathogenic mechanisms involved in rheumatoid arthritis, other types of inflammatory arthritis and osteoarthritis. Using this information, new therapeutic agents are developed and tested to determine both their clinical efficacy and their effect upon pathogenic pathways that result in inflammation and/or joint damage. Examples of this strategy are the studies that showed minocycline to be an effective drug for rheumatoid arthritis. Minocycline is an antibiotic that also inhibits the inflammatory response and the enzymatic processes that degrade cartilage and connective tissue. This has provided the rationale for studying whether minocycline, or other tetracycline antibiotics, can slow the progression of osteoarthritis.It has been established that biologic agents that inhibit tumor necrosis factor a (TNFa ) are remarkably effective in the treatment of rheumatoid arthritis. However, it is not known what cellular mechanisms and signaling pathways are influenced by anti-TNFa agents. Clinical research and in vitro studies are in progress to determine what changes occur in patients treated with anti-TNFa drugs, with emphasis on the p38 MAP kinase.

Academic Appointments

1974-1979 Assistant Professor of Medicine, University of Southern California School of Medicine, Los Angeles, California
1980-1982 Associate Professor of Medicine, USC School of Medicine
1981-1982 Research Coordinator, Clinical Immunology and Rheumatic Disease Section, University of Southern California School of Medicine
1982-1986 Associate Professor of MedicineDirector, Rheumatology and Clinical Immunology Unit, University of Vermont College of Medicine, Burlington, Vermont
1986-present Professor of Medicine, Rheumatology and Clinical Immunology Unit, University of Vermont College of Medicine, Burlington, Vermont

Publications

Carbone G, Wilson A, Diehl SA, Bunn J, Cooper SM, Rincon M. Interleukin-6 receptor blockade selectively reduces IL-21 production by CD4 T cells and IgG4 autoantibodies in rheumatoid arthritis. Int J Biol Sci. 2013;9(3):279-88. PubMed PMID: 23493630; PubMed Central PMCID: PMC3596713. <?xml:namespace prefix = o ns = "urn:schemas-microsoft-com:office:office" /><o:p></o:p>

Garfield BE, Krahl T, Appel S, Cooper SM, Rincón M. Regulation of p38 MAP kinase in CD4+ lymphocytes by infliximab therapy in patients with rheumatoid arthritis. Clin Immunol. 2005 Aug;116(2):101-7. PubMed PMID: 15914087. <o:p></o:p>

Levine JW, Gota C, Fessler BJ, Calabrese LH, Cooper SM. Persistent cryoglobulinemic vasculitis following successful treatment of hepatitis C virus. J Rheumatol. 2005 Jun;32(6):1164-7. PubMed PMID: 15940780. <o:p></o:p>

Dupuis DE, Beynnon BD, Richard MJ, Novotny JE, Skelly JM, Cooper SM. Precision and accuracy of joint space width measurements of the medial compartment of the knee using standardized MTP semi-flexed radiographs. Osteoarthritis Cartilage. 2003 Oct;11(10):716-24. PubMed PMID: 13129690. <o:p></o:p>

Cooper SM, Libman BS, Lazarovich M. Churg-strauss syndrome in a group of patients receiving fluticasone for asthma. J Rheumatol. 2002 Dec;29(12):2651-2. PubMed PMID: 12465168. <o:p></o:p>

Saleem G, Li SC, MacPherson BR, Cooper SM. Hepatitis with interface inflammation and IgG, IgM, and IgA anti-double-stranded DNA antibodies following infliximab therapy: comment on the article by Charles et al. Arthritis Rheum. 2001 Aug;44(8):1966-8. PubMed PMID: 11508453. <o:p></o:p>

Salahuddin N, Libman BS, Lunde JH, Kay J, Cooper SM. The association of relapsing polychondritis and myelodysplastic syndrome: report of three cases. J Clin Rheumatol. 2000 Jun;6(3):146-9. PubMed PMID: 19078463. <o:p></o:p>

Cooper SM. A perspective on the use of minocycline for rheumatoid arthritis. J Clin Rheumatol. 1999 Aug;5(4):233-7; discussion 237-8. PubMed PMID: 19078393. <o:p></o:p>

McDermott MF, Aksentijevich I, Galon J, McDermott EM, Ogunkolade BW, Centola M, Mansfield E, Gadina M, Karenko L, Pettersson T, McCarthy J, Frucht DM, Aringer M, Torosyan Y, Teppo AM, Wilson M, Karaarslan HM, Wan Y, Todd I, Wood G, Schlimgen R, Kumarajeewa TR, Cooper SM, Vella JP, Amos CI, Mulley J, Quane KA, Molloy MG, Ranki A, Powell RJ, Hitman GA, O'Shea JJ, Kastner DL. Germline mutations in the extracellular domains of the 55 kDa TNF receptor, TNFR1, define a family of dominantly inherited autoinflammatory syndromes. Cell. 1999 Apr 2;97(1):133-44. PubMed PMID: 10199409. <o:p></o:p>

Roessner K, Trivedi H, Gaur L, Howard D, Aversa J, Cooper SM, Sigal LH, Budd RC. Biased T-cell antigen receptor repertoire in Lyme arthritis. Infect Immun. 1998 Mar;66(3):1092-9. PubMed PMID: 9488400; PubMed Central PMCID: PMC108020. <o:p></o:p>

Buckley LM, Leib ES, Cartularo KS, Vacek PM, Cooper SM. Effects of low dose methotrexate on the bone mineral density of patients with rheumatoid arthritis. J Rheumatol. 1997 Aug;24(8):1489-94. PubMed PMID: 9263140. <o:p></o:p>

Bluhm GB, Sharp JT, Tilley BC, Alarcon GS, Cooper SM, Pillemer SR, Clegg DO, Heyse SP, Trentham DE, Neuner R, Kaplan DA, Leisen JC, Buckley L, Duncan H, Tuttleman M, Li S, Fowler SE. Radiographic results from the Minocycline in Rheumatoid Arthritis (MIRA) Trial. J Rheumatol. 1997 Jul;24(7):1295-302. PubMed PMID: 9228128. <o:p></o:p>

Pillemer SR, Fowler SE, Tilley BC, Alarcón GS, Heyse SP, Trentham DE, Neuner R, Clegg DO, Leisen JC, Cooper SM, Duncan H, Tuttleman M. Meaningful improvement criteria sets in a rheumatoid arthritis clinical trial MIRA Trial Group Minocycline in Rheumatoid Arthritis. Arthritis Rheum. 1997 Mar;40(3):419-25. PubMed PMID: 9082927. <o:p></o:p>

Buckley LM, Leib ES, Cartularo KS, Vacek PM, Cooper SM. Calcium and vitamin D3 supplementation prevents bone loss in the spine secondary to low-dose corticosteroids in patients with rheumatoid arthritis A randomized, double-blind, placebo-controlled trial. Ann Intern Med. 1996 Dec 15;125(12):961-8. PubMed PMID: 8967706. <o:p></o:p>

Vincent MS, Roessner K, Lynch D, Wilson D, Cooper SM, Tschopp J, Sigal LH, Budd RC. Apoptosis of Fashigh CD4+ synovial T cells by borrelia-reactive Fas-ligand(high) gamma delta T cells in Lyme arthritis. J Exp Med. 1996 Dec 1;184(6):2109-17. PubMed PMID: 8976167; PubMed Central PMCID: PMC2196368. <o:p></o:p>

Battle RW, Davitt MA, Cooper SM, Buckley LM, Leib ES, Beglin PA, Tischler MD. Prevalence of pulmonary hypertension in limited and diffuse scleroderma. Chest. 1996 Dec;110(6):1515-9. PubMed PMID: 8989070. <o:p></o:p>

Reveille JD, Alarcón GS, Fowler SE, Pillemer SR, Neuner R, Clegg DO, Mikhail IS, Trentham DE, Leisen JC, Bluhm G, Cooper SM, Duncan H, Tuttleman M, Heyse SP, Sharp JT, Tilley B. HLA-DRB1 genes and disease severity in rheumatoid arthritis The MIRA Trial Group Minocycline in Rheumatoid Arthritis. Arthritis Rheum. 1996 Nov;39(11):1802-7. PubMed PMID: 8912501. <o:p></o:p>

Cooper SM, Roessner KD, Naito-Hoopes M, Dobbs C, Nicklas JA, Howard DB, Gaur LK, Budd RC. Unstimulated rheumatoid synovial T-cells have a consistent V beta gene bias when compared to peripheral blood T-cells. Ann N Y Acad Sci. 1995 Jul 7;756:186-9. PubMed PMID: 7645827. <o:p></o:p>

Cooper SM, Lipsky PE. T-cell receptor use in rheumatoid arthritis. Ann N Y Acad Sci. 1995 Jul 7;756:229-32. PubMed PMID: 7645842. <o:p></o:p>

Clements JL, Cooper SM, Budd RC. Abnormal regulation of the IL-2 promoter in lpr CD4-CD8- T lymphocytes results in constitutive expression of a novel nuclear factor of activated T cells-binding factor. J Immunol. 1995 Jun 15;154(12):6372-81. PubMed PMID: 7759875. <o:p></o:p>

Buckley LM, Leib ES, Cartularo KS, Vacek PM, Cooper SM. Effects of low dose corticosteroids on the bone mineral density of patients with rheumatoid arthritis. J Rheumatol. 1995 Jun;22(6):1055-9. PubMed PMID: 7674230. <o:p></o:p>

Tilley BC, Alarcón GS, Heyse SP, Trentham DE, Neuner R, Kaplan DA, Clegg DO, Leisen JC, Buckley L, Cooper SM, Duncan H, Pillemer SR, Tuttleman M, Fowler SE. Minocycline in rheumatoid arthritis A 48-week, double-blind, placebo-controlled trial MIRA Trial Group. Ann Intern Med. 1995 Jan 15;122(2):81-9. PubMed PMID: 7993000. <o:p></o:p>

Cooper SM, Roessner KD, Naito-Hoopes M, Howard DB, Gaur LK, Budd RC. Increased usage of V beta 2 and V beta 6 in rheumatoid synovial fluid T cells. Arthritis Rheum. 1994 Nov;37(11):1627-36. PubMed PMID: 7980675. <o:p></o:p>

Clements JL, Wolfe J, Cooper SM, Budd RC. Reversal of hyporesponsiveness in lpr CD4-CD8- T cells is achieved by induction of cell cycling and normalization of CD2 and p59fyn expression. Eur J Immunol. 1994 Mar;24(3):558-65. PubMed PMID: 7510235. <o:p></o:p>

Roessner K, Fikrig E, Russell JQ, Cooper SM, Flavell RA, Budd RC. Prominent T lymphocyte response to Borrelia burgdorferi from peripheral blood of unexposed donors. Eur J Immunol. 1994 Feb;24(2):320-4. PubMed PMID: 7905415. <o:p></o:p>

Clements JL, Winslow G, Donahue C, Cooper SM, Allison JP, Budd RC. Co-stimulation via CD28 induces activation of a refractory subset of MRL-lpr/lpr T lymphocytes. Int Immunol. 1993 Nov;5(11):1451-60. PubMed PMID: 7903158. <o:p></o:p>

Budd RC, Russell JQ, van Houten N, Cooper SM, Yagita H, Wolfe J. CD2 expression correlates with proliferative capacity of alpha beta + or gamma delta + CD4-CD8- T cells in lpr mice. J Immunol. 1992 Feb 15;148(4):1055-64. PubMed PMID: 1346621. <o:p></o:p>

Cooper SM, Dier DL, Roessner KD, Budd RC, Nicklas JA. Diversity of rheumatoid synovial tissue T cells by T cell receptor analysis Oligoclonal expansion in interleukin-2-responsive cells. Arthritis Rheum. 1991 May;34(5):537-46. PubMed PMID: 2025307. <o:p></o:p>

Buckley LM, Vacek PM, Cooper SM. Administration of folinic acid after low dose methotrexate in patients with rheumatoid arthritis. J Rheumatol. 1990 Sep;17(9):1158-61. PubMed PMID: 2132565. <o:p></o:p>

Cooper SM. Pseudopodagra in young women. Arthritis Rheum. 1990 Apr;33(4):607-8. PubMed PMID: 2360955. <o:p></o:p>

Buckley LM, Vacek P, Cooper SM. Educational and psychosocial needs of patients with chronic disease A survey of preferences of patients with rheumatoid arthritis. Arthritis Care Res. 1990 Mar;3(1):5-10. PubMed PMID: 2285739. <o:p></o:p>

Cooper SM, Sriram S, Ranges GE. Suppression of murine collagen-induced arthritis with monoclonal anti-Ia antibodies and augmentation with IFN-gamma. J Immunol. 1988 Sep 15;141(6):1958-62. PubMed PMID: 3139747. <o:p></o:p>

Ranges GE, Fortin S, Barger MT, Sriram S, Cooper SM. In vivo modulation of murine collagen induced arthritis. Int Rev Immunol. 1988 Sep;4(1):83-90. PubMed PMID: 3149663. <o:p></o:p>

Cooper SM, Roessner K, Ferriss JA, Baigent G, Bakke AC. Increase in OKM1+ granular lymphocytes in patients with rheumatoid arthritis. Arthritis Rheum. 1987 Oct;30(10):1089-96. PubMed PMID: 3675656. <o:p></o:p>

Robbins DC, Cooper SM, Fineberg SE, Mead PM. Antibodies to covalent aggregates of insulin in blood of insulin-using diabetic patients. Diabetes. 1987 Jul;36(7):838-41. PubMed PMID: 2438179. <o:p></o:p>

Ranges GE, Cooper SM, Sriram S. In vivo immunomodulation by monoclonal anti-L3T4 1 Effects on humoral and cell-mediated immune response. Cell Immunol. 1987 Apr 15;106(1):163-73. PubMed PMID: 3494534. <o:p></o:p>

Weisman LF, Hebert JC, Cooper SM. Reiter's syndrome and recurrent peritonitis after appendectomy. Surgery. 1987 Apr;101(4):508-10. PubMed PMID: 3563899. <o:p></o:p>

Cooper SM, Ferriss JA. Reactive arthritis and psittacosis. Am J Med. 1986 Sep;81(3):555-7. PubMed PMID: 3752154. <o:p></o:p>

Bakke AC, Gray JD, Abo W, Quismorio FP Jr, Lash A, Cooper SM, Horwitz DA. Studies on human blood lymphocytes with iC3b (type 3) complement receptors I Granular, Fc-IgG receptor positive and negative subsets in healthy subjects and patients with systemic lupus erythematosus. J Immunol. 1986 Feb 15;136(4):1253-9. PubMed PMID: 2935574. <o:p></o:p>

Ranges GE, Sriram S, Cooper SM. Prevention of type II collagen-induced arthritis by in vivo treatment with anti-L3T4. J Exp Med. 1985 Sep 1;162(3):1105-10. PubMed PMID: 3928802; PubMed Central PMCID: PMC2187818. <o:p></o:p>

Bland JH, Cooper SM. Osteoarthritis: a review of the cell biology involved and evidence for reversibility Management rationally related to known genesis and pathophysiology. Semin Arthritis Rheum. 1984 Nov;14(2):106-33. PubMed PMID: 6399624. <o:p></o:p>

Lane BC, Bricker MD, Cooper SM. Fc receptors of mouse cell lines II IgG binding specificity and identification of the Fc receptor on a lymphoid leukemia. J Immunol. 1982 Apr;128(4):1825-31. PubMed PMID: 6977571. <o:p></o:p>

Lane BC, Cooper SM. Fc receptors of mouse cell lines I Distinct proteins mediate the IgG subclass-specific Fc binding activities of macrophages. J Immunol. 1982 Apr;128(4):1819-24. PubMed PMID: 7061850. <o:p></o:p>

Tak HK, Wilcox WR, Cooper SM. The effect of lead upon urate nucleation. Arthritis Rheum. 1981 Oct;24(10):1291-5. PubMed PMID: 7306230. <o:p></o:p>

Lane BC, Kan-Mitchell J, Mitchell MS, Cooper SM. Structural evidence for distinct IgG subclass-specific Fc receptors on mouse peritoneal macrophages. J Exp Med. 1980 Nov 1;152(5):1147-61. PubMed PMID: 7430949; PubMed Central PMCID: PMC2185986. <o:p></o:p>

Tak HK, Cooper SM, Wilcox WR. Studies on the nucleation of monosodium urate at 37 degrees c. Arthritis Rheum. 1980 May;23(5):574-80. PubMed PMID: 7378087. <o:p></o:p>

Cooper SM, Keyser AJ, Beaulieu AD, Ruoslahti E, Nimni ME, Quismorio FP Jr. Increase in fibronectin in the deep dermis of involved skin in progressive systemic sclerosis. Arthritis Rheum. 1979 Sep;22(9):983-7. PubMed PMID: 383087. <o:p></o:p>

Cooper SM. Fc-receptor dysfunction in lupus. N Engl J Med. 1979 Jun 28;300(26):1486. PubMed PMID: 449889. <o:p></o:p>

Cooper SM, Friou GJ. Cytotoxicity in progressive systemic sclerosis: no evidence for increased cytotoxicity against fibroblasts of different origin. J Rheumatol. 1979 Jan-Feb;6(1):25-9. PubMed PMID: 439107. <o:p></o:p>

Cooper SM, Harding B, Mirick GR, Schneider J, Quismorio FP, Friou GJ. Selective decrease in antibody-dependent cell-mediated cytotoxicity in systemic lupus erythematosus and progressive systemic sclerosis. Clin Exp Immunol. 1978 Nov;34(2):235-40. PubMed PMID: 737908; PubMed Central PMCID: PMC1537498. <o:p></o:p>

Cooper SM, Sambray Y, Frious GJ. Isolation of separate Fc receptors for IgG complexed to antigen and native IgG from a murine leukaemia. Nature. 1977 Nov 17;270(5634):253-5. PubMed PMID: 563516. <o:p></o:p>

Noyes FR, Grood ES, Nussbaum NS, Cooper SM. Effect of intra-articular corticosteroids on ligament properties: a biomechanical and histological study in rhesus knees. Clin Orthop Relat Res. 1977 Mar-Apr;PubMed PMID: 404109. <o:p></o:p>

Cooper SM, Sambray Y. Characterization of the Fc receptors of the murine leukemia L1210. J Supramol Struct. 1977;6(4):591-7. PubMed PMID: 563497. <o:p></o:p>

Cooper SM, Sambray Y. Isolation of a murine leukemia FC receptor by selective release induced by surface redistribution. J Immunol. 1976 Aug;117(2):511-7. PubMed PMID: 1084901. <o:p></o:p>

Schneider J, Chin W, Friou GJ, Cooper SM, Harding B, Hill RL, Quismorio FP. Reduced antibody-dependent cell-mediated cytotoxicity in systemic lupus erythematosus. Clin Exp Immunol. 1975 May;20(2):187-92. PubMed PMID: 1212807; PubMed Central PMCID: PMC1538206. <o:p></o:p>

Cooper SM, Franklin EC, Frangione B. Molecular defect in a gamma-2 heavy chain. Science. 1972 Apr 14;176(4031):187-9. PubMed PMID: 4111345. <o:p></o:p>

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Garfield BE, Krahl T, Appel S, Cooper SM, Rincon M. Regulation of p38 MAP kinase in CD4+ lymphocytes by infliximab therapy in patients with rheumatoid arthritis. Clin Immunol. 2005 Aug;116(2):101-7. PubMed PMID: 15914087.

Levine JW, Gota C, Fessler BJ, Calabrese LH, Cooper SM. Persistent cryoglobulinemic vasculitis following successful treatment of hepatitis C virus. J Rheumatol. 2005 Jun;32(6):1164-7. PubMed PMID: 15940780.

Dupuis DE, Beynnon BD, Richard MJ, Novotny JE, Skelly JM, Cooper SM. Precision and accuracy of joint space width measurements of the medial compartment of the knee using standardized MTP semi-flexed radiographs. Osteoarthritis Cartilage. 2003 Oct;11(10):716-24. PubMed PMID: 13129690.

To view more of Dr. Cooper's publications, please visit PubMed.