University of Vermont

College of Medicine

Department of Medicine

Pulmonary Disease & Critical Care Medicine

research

Research

Dr. Charles Irvin

Our division's research reputation in asthma, stem cell, obesity, and lung disease has grown internationally. Faculty involvement in clinical research projects include asthma, idiopathic pulmonary fibrosis, critical care, and cystic fibrosis. Basic science and translational research focuses on airway disease biology and animal modeling of asthma and other airway diseases. Daniel Weiss, M.D., Ph.D., received a prestigious $4.26 million Opportunity Grant from the NIH to support his work on a novel approach to use stem cells to engineer new lungs for patients with end-stage lung disease.

The Pulmonary division is home to an American Lung Association Asthma Clinical Research Center, one of 18 such centers in the country, and the only one in New England. Much of the research takes place at the Vermont Lung Center, funded by an NIH Center of Biomedical Research Excellence grant, in its third five-year cycle.

Recently the University of Vermont hosted more than 120 experts from around the world for the biannual "Stem Cells and Cell Therapies in Lung Biology and Lung disease" event. The division also hosted the first international conference on obesity and lung disease in Stowe, Vermont.

Research Programs

Additional areas of research include:

  • Mathematical modeling of lung mechanics
  • Occupational & environmental lung diseases
  • Pulmonary physiology and lung mechanics in asthma
  • Pathogenesis of acute lung injury
  • Th2 medicated airway inflammation in CF and asthma
  • Sinus disease and rhinitis effect on the control of asthma
  • Airway epithelial signaling in inflammation
  • Redox signaling and inflammatory lung disease
  • Signaling pathways and gene regulation of cytokines
  • Oxidative stress in lung inflammation
  • Repopulation of pulmonary epithelium with stem cell transplantation
  • Gene & stem cell therapies for lung disease
  • Impact of system changes and organization on medical outcomes in the ICU
  • Improving tobacco use and dependence treatment

Last modified December 17 2013 03:21 PM