Infectious Disease : University of Vermont

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Department of Medicine

Infectious Disease

Bio for Christopher Huston, M.D.

Christopher Huston, M.D.

Associate Professor of Medicine, Infectious Disease Medicine
Department of Medicine

Contact Information

Phone: (802) 847-2264
Office Location: Fletcher Allen Health Care, 111 Colchester Avenue, Smith 260, Burlington, VT 05401

Website

Huston Lab

Education

1986-1990 Cornell University, Ithaca, NY; B.A. in physics; Minor in biochemistry
1990-1994 Cornell University Medical College, New York, NY; M.D.

Research Interests

Characterization of the mechanism of phagocytosis of host cells by the intestinal amoeba Entamoeba histolytica
Development of new drug treatments for Cryptosporidium parasites using a cell-based screening assay

Academic Appointments

Associate Professor, Dept. of Medicine, University ofVermont, College of Medicine
Adjunct Faculty, Dept of Microbiology and Molecular Genetics, University of Vermont, College of Agricultural and Life Sciences
Adjunct Faculty, Cell and Molecular Biology, University of Vermont

Research Grants

2003-2009 Principal Investigator
NIH/NIAID K08 AI053678
Project title: Entamoeba histolytica phagocytosis of apoptotic host cells

2008-2013 Principal Investigator
NIH/NIAID 1 R01 AI072021
Project title: Molecular Mechanism of
Entamoeba histolytica phagocytosis

2010-2012 Principal Investigator
The Campbell Foundation
Project title: Targeting human proteins for treatment of Cryptosporidiosis.

Awards and Honors

1993 Alpha Omega Alpha Medical Honor Society; Cornell University Medical College
1999 Young Investigator Award; American Society of Tropical Medicine and Hygiene
2001 Postdoctoral Fellowship for Physicians; Howard Hughes Medical Institute
2007 Young Investigator Award; American Society for Clinical Investigation
2011 Junior Researcher of the Year; University of Vermont Medical Group; University of Vermont College of Medicine

Publications

Jose Teixeira, Adam Sateriale, Koval Bessof and Christopher Huston, MD.Fungal and parasitic Infections:
Control of entamoeba histolytica Adherence involves Metallosurface Protease 1, and M8 Family Surface Metalloprotease withHomology to Leishmanolysin.Infect. inImmunity. 2012 80:2165-2176
Huston CD, Boettner DR, Miller-Sims V, Petri WA. Apoptotic killing and phagocytosis of host cells by the parasite Entamoeba histolytica. Infection and Immunity. 2003 Feb;71(2):964-972

Teixeira JE, Huston CD. Participation of the serine-rich Entamoeba histolytica protein in amebic phagocytosis of apoptotic host cells. Infection and Immunity. 2008. 76:959-966

Teixeira JE, Huston CD. Evidence of a continuous endoplasmic reticulum in the protozoan parasite Entamoeba histolytica. Eukaryotic Cell. 2008. 7:1222-1226.

Teixeira JE, Heron B, Huston CD. C1q- and collectin-dependent phagocytosis of apoptotic host cells by the intestinal protozoan Entamoeba histolytica. Journal of Infectious Diseases. 2008. 198:1062-1070

Heron BT, Sateriale A, Teixeira JE, Huston CD. Evidence for a novel Entamoeba histolytica lectin activity that recognizes carbohydrates present on ovalbumin. International Journal for Parasitology. 2011. 41:137-44

For more publications see pubmed link

Archana Vaithillingham Jose Teixeria, Peter Miller, Bradley Heron, Christopher Huston. Cellular Microbiology: Pathogen-host cell molecular Interactions: entamoebahistolytica Cell Surface Calriticulin binds Human C1Q and functions in Amebic Phagocytosis of host cells. Infect. Immun. June 2012