Utah State University, Logan, UT - BS - 1977 Bacteriology-Microbiology
Brigham Young University, Provo, UT - MS - 1978 Microbiology-Immunology
University of New Mexico, Albuquerque, NM - Ph.D.
University of New Mexico School of Medicine, Albuquerque, NM Post. Doc. 1982-1984 Pathology
Immunogenetics and infectious/autoimmune diseases
1984-1990 Assistant Professor, Division of Reproductive Biology, Department of Obstetrics and Gynecology, The University of Pennsylvania, Philadelphia, PA
1990-1995 Adjunct Research Associate Professor, Division of Reproductive Biology, Department of Obstetrics and Gynecology, The University of Pennsylvania, Philadelphia, PA1990-1996 Associate Professor, Department of Microbiology, Brigham Young University, Provo, UT
1996-1999 Associate Professor, Department of Veterinary Pathobiology, Pathology, and Animal Science, University of Illinois at Urbana-Champaign, Urbana, IL1999-2001 Professor, Department of Veterinary Pathobiology, Pathology, and Animal Science, University of Illinois at Urbana-Champaign, Urbana, IL
2001 - Present Professor of Medicine, University of Vermont, Burlington, VTR01 NS36526 Teuscher (PI) 07/01/00 - 06/30/04 10%
Susceptibility and Resistance Loci in EAE
The major goal of this project is to map the genes in the mouse that control susceptibility to experimental allergic encephalomyelitis (EAE), the principal animal model of multiple sclerosis.
R01 AI41747 Teuscher (PI) 01/01/97 - 12/31/03 10%NIH/NIAID $150,000 Autoimmune Disease and Neonatal ToleranceThe major goal of this project is to: 1) generate a panel of congenic mice to physically place the Aod1 locus within a support interval of sufficient size to positionally clone the gene, and 2) construct a YAC contig across this interval.R01 AR43521 Weis (PI) 06/01/99 - 03/31/04 20%
Principal Investigator: Janis Ph.D. Subcontract PI: Teuscher $110,000
Molecular Genetics of Arthritis in Murine Lyme Disease
The major goal of this project is to physically map the QTL in the mouse that control susceptibility to arthritis in murine Lyme disease.
R01 AI45105 Teuscher (PI) 04/01/99 - 03/31/03 10%NIH/NIAID $115,000Immunoregulatory Loci in Organ-Specific AutoimmunityThe objective of this study is to positionally clone the immunoregulatory locus (Orch3) controlling dominant resistance to autoimmune orchitis.RG 3129-A-3 Teuscher (PI) 09/30/99 - 08/31/04 10%
National Multiple Sclerosis Society $210,000
Genetic Basis for Gender Differences in EAE Susceptibility
The objective of this study is to determine the genetic basis underlying the sexual dimorphism in experimental allergic encephalomyelitis in mice.
PP0625 Teuscher (PI) 09/1/98 - 08/31/99 National Multiple Sclerosis Society $25,000 Immunogenetics of TMEV-Induced DemyelinationThis project was to complete the development of a speed congenic around the Tmevd2 locus, a susceptibility gene in Theiler’s murine encephalomyelitis-induced demyelination.Teuscher (PI) 2003-2008 10%
National Multiple Sclerosis Society $150,000
Collaborative MS Research Center Award
This project proposes to examine the molecular basis for defective signal transduction through the H1R and resistance to EAE. Additionally, the roles of H2R, H3R and H4R signaling in the pathogenesis of EAE will be examined.
Overlap: There is overlap with this application only with respect to the studies on the H1R. In the event that both applications are funded, then we will negotiate with the NMSS to fund only those studies dealing with the H2R, H3R and H4R
Teuscher (PI) 2003-2008 20%Wadsworth Foundation $250,000Histamine Receptor Signaling in Central Nervous System Autoimmune DiseaseThis project proposes to examine the role of histamine H2, H3 and H4 receptor in regulating autoimmune disease of the central nervous system. These studies will use the murine model of experimental allergic encephalomyelitis and focus on both the mechanistic basis and potential therapeutic use of histamine receptor selective agonists and antagonists in the potential treatment of EAE as a model for multiple sclerosis.Overlap: None. Different receptors polymorphisms and signaling pathways are being investigated.Roper RJ, McAllister RD, Biggins JE, Michael SD, Min SH, Tung KS, Call SB, Gao J, Teuscher C. Aod1 controlling day 3 thymectomy-induced autoimmune ovarian dysgenesis in mice encompasses two linked quantitative trait loci with opposing allelic effects on disease susceptibility. J. Immunol. 170:5886, 2003.
McAllister RD, Singh Y, du Bois WD, Potter M, Boehm T, Meeker ND, Fillmore PD, Anderson LM, Poynter ME, Teuscher C. Susceptibility to anthrax lethal toxin is controlled by three linked quantitative trait loci. Am. J. Pathol. 163:1735, 2003.Teuscher C, Poynter ME, Offner H, Zamora A, Watanabe T, Fillmore PD, Zachary JF, Blankenhorn EP. Attenuation of Th1 effector cell responses and susceptibility to experimental allergic encephalomyelitis in histamine H2 receptor knockout mice is due to dysregulation of cytokine production by antigen-presenting cells. Am. J. Pathol. 164:883, 2004.
Teuscher, C., Blankenhorn, E.P., Fillmore, P.D., Diehl, S.A. and Rincon, M. 2003. Identification of Ifngr Polymorphism Affecting Signaling as a Candidate for eae15 Controlling Lesion Severity and Mononuclear Cell Infiltration in the Brain. J. Immunol. Fillmore, P.D., Brace, M., Troutman, S.A., Blankenhorn, E.P., Rincon, M., Diehl, S.A., and Teuscher, C. 2003. Identification of Quantitative Trait Loci Controlling the Microstructure-Based Encephalitogencity of the Particles Comprising Neuroantigen-Complete Freund’s Adjuvant Emulsions. J. Immunol. (Submitted).
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