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Marney Research Program
The clearance receptor for BNP is located in adipose tissue, among other tissues, and preliminary data suggest that the clearance receptor may be upregulated in obesity. In addition, Dr. Marney has studied the blood pressure effects of a class of anti-diabetic agents, dipeptidyl peptidase-IV (DPP-4) inhibitors, and found that DPP-4 inhibitors interact with ACE inhibitors. Since DPP-4 inhibitors help degrade BNP, the effects of DPP-4 inhibition on BNP and its metabolism are current research interests. In addition, she collaborates on the potential effects of exercise to reverse hyperglycemia in newly diagnosed Type 2 DM. Finally, she has experience using continuous glucose monitoring (CGM) in patients with heart failure and autonomic neuropathy.
- Metabolism and biology of BNP in obesity
- Clearance receptor expression of BNP in adipose tissue
- Glycemic variability as measured by continuous glucose monitoring in patients with heart failure and/or autonomic dysfunction
- Clinical research study design and implementation
- Microdialysis in subcutaneous adipose tissue to look at local cytokine and hormone production
- Adipose tissue biopsy
Last modified April 13 2016 12:09 PM