University of Vermont

College of Medicine

Department of Medicine

Endocrinology, Diabetes & Metabolism

Bio for Dhananjay Gupta, Ph.D.
Dhananjay Gupta, Ph.D.

Dhananjay Gupta, Ph.D.

Research Assistant Professor, Department of Medicine, Division of Endocrinology, Diabetes and Metabolism


Contact Information
E-mail: Dhananjay.Gupta@uvm.edu
Office Location:
UVM Colchester Research Facility, 360 South Park Drive, Colchester, VT 05446

Education

B.Sc. in Zoology (Honors), Banaras Hindu University, Varanasi, India, 1992
M.Sc. in Life Sciences, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India, 1994
Ph.D. in Life Sciences, Biochemistry and Molecular Biology, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India, 2000; Mentor: Prof. NZ Baquer

Academic Interests

Pathogenesis of type 2 diabetes
Islet beta cell biology
Molecular mechanisms of adaptive islet beta cell response with changing metabolic milieu
Role of the transcription factors acting as molecular switches in regulation of islet beta cell function and survival 

Expertise

Molecular biology and cellular signaling

Academic Appointments

Ph.D. Research Fellow at School of Life Sciences, Jawaharlal Nehru University, New Delhi, India, 1994-1999
Post-Doctoral Fellow in Department of Biochemistry, College of Medicine, University of Saskatchewan, Saskatoon, Canada, 2001-2001; Mentor: Prof. R.L. Khandelwal
Post-Doctoral Associate in Division of Endocrinology, Diabetes and Metabolism, University of Vermont, 2005-2009; Mentor: Prof. Jack L. Leahy
Research Assistant Professor at Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, 2010-2011
Research Assistant Professor
in Endocrinology, Diabetes and Metabolism, University of Vermont, 2011-present

Awards and Honors

Competitive University Grants Commission Certificate for Graduate teaching at College/University levels, 1994

Competitive University Grants Commission, India (UGC) Junior & Senior PhD Research Fellowship, 1994-1999
Competitive Post-Doctoral Fellowship Dept of Medicine, University of Saskatchewan, 2001-2004
Mentor-based Post-doctoral Fellowship (Sponsor: Prof. Jack L Leahy), American Diabetes Association, 2005-2009

IGP Award, College of Medicine, University of Vermont 2011-2013

Publications (Peer Reviewed)

Moibi JA*, Gupta D*, Jetton TL, Peshavaria M, Desai R, Leahy JL Peroxisome proliferator-activated receptor-gamma regulates expression of PDX-1 and NKX6.1 in INS-1 cells. Diabetes. 2007; 56:88-95. * Equal contribution

Gupta D, Jetton TL, Mortensen RM, Duan SZ, Peshavaria M, Leahy JL. Molecular characterization of a functional peroxisome proliferator-activated receptor-gamma response element in the mouse PDX-1 promoter.  J Biol Chem. 2008; 283:32462-32470.

Delghingaro-Augusto V, Nolan CJ, Gupta D, Jetton TL, Latur MA, Peshavaria M, Madiraju SRM, Prentki M, Leahy JL. Beta cell failure in the 60% pancreatectomised obese hyperlipidaemic Zucker fatty rat: Severe dysfunction with altered glycerolipid metabolism without steatosis or a falling beta cell mass. Diabetologia. 2009; 56:1122-1132.

Gupta D, Peshavaria M, Monga N, Jetton TL, Leahy JL. Physiologic and pharmacologic modulation of glucose-dependent insulinotropic polypeptide (GIP) receptor expression in beta cells by peroxisome proliferator-activated receptor (PPAR)-gamma signaling: Possible mechanism for the GIP resistance in type 2 diabetes. Diabetes. 2010; 59:1445-1450.

Gupta D, Kono T, Evans-Molina C. The role of peroxisome proliferator-activated receptor gamma in pancreatic ß cell function and survival: Therapeutic implications for the treatment of type 2 diabetes mellitus. Diabetes Obes Metab. 2010; 12:1036-1047.

For a complete list of Dr. Gupta's publications, please visit Pub Med