University of Vermont

College of Medicine

Department of Medicine

Endocrinology, Diabetes & Metabolism

Bio for C. Lawrence Kien, M.D., Ph.D.
C. Lawrence Kien, M.D., Ph.D.

C. Lawrence Kien, M.D., Ph.D.

Department of Pediatrics
Department of Medicine
Division of Endocrinology

Contact Information
Office Location:
UVM Colchester Research Facility, 360 South Park Drive, Colchester, VT 05446


Ph.D., Nutritional Biochemistry and Metabolism, MIT, Cambridge, MA (1977)
M.D., University of Cincinnati College of Medicine, Cincinnati, OH (1972)
B.S. in Zoology, Duke University, Durham, NC (1968)

Academic Interests

Research: Effects of long and short chain fatty acids on metabolism and on risks for obesity, type 2 diabetes, and impaired cognitive aging.
Teaching: Nutrient deficiences, inborn errors of metabolism, obesity, type 2 diabetes, gastroenterology.

Academic Appointments

Professor, Departments of Pediatrics and Medicine, The Robert Larner, M.D. College of Medicine at The University of Vermont, Burlington, VT (2004-present)
The Mary Kay Davignon Green and Gold Professor of Pediatrics and Medicine, The Robert Larner, M.D. College of Medicine at The University of Vermont (2005-present)

Research Grants

Recent funding:
Examining the effects of consuming a diet comprising of milk fat-containing dairy products on metabolic health markers (J. Kraft, PI; C.L. Kien, Co-I)
     04/01/2013-03/31/2016; Dairy Research Institute

Dietary saturated and monounsaturated fatty acids and cognition (J.A. Dumas and C.L. Kien, Co-PIs)
     03/01/2014-02/28/2016; University of Vermont Center on Aging

Palmitate metabolism and insulin resistance (C.L. Kien, PI)
     04/01/2010-12/31/2015; NIDDK

Mechanisms for differential effects of dietary fatty acids on metabolism (C.L. Kien, PI)
     04/13/2007-03/31/2012; NIDDK

Awards and Honors

Clinical and Integrative Diabetes and Obesity (CIDO) Study Section (Regular Member) (07/01/2007 - 06/30/2011)
Biochemistry Test Committee, National Board of Medical Examiners (NBME) (1998-2002)
Step 1 Test Material Development Committee for Biochemistry United States Medical Licensing Examination (USMLE) (1998-2002)
Consultant (for Carbohydrates) Term Panel, Life Sciences Research Office (FASEB), (Advisory to FDA) (1996 - 2001)
Ad Hoc Expert Panel: Review of infant formula nutrient requirements for preterm infants, Life Sciences Research Office (FASEB), (Advisory to FDA)
Ad Hoc Review of the USMLE Step 1 Pass/Fall Standard (April, 2000)
Nutrition Study Section (1989 - 1993)
Special Fellow, Leukemia Society of America, Inc. (1981)
Future Leaders Award, The Nutrition Foundation, Inc. (1980)

Publications (Peer Reviewed)

Kien CL, Matthews DE, Poynter ME, Bunn JY, Fukagawa NK, Crain KI, Ebenstein DB, Tarleton EK, Stevens RD, Koves TR, Muoio DM.  Increased palmitate intake: higher acylcarnitine concentrations without impaired progression of ß-oxidation. J Lipid Res. 2015;56:1795-807, PMID 26156077

ien CL, Bunn JY, Fukagawa NK, Anathy V, Matthews DE, Crain KI, Ebenstein DB, Tarleton EK, Pratley RE, Poynter ME.  Lipidomic evidence that lowering the typical dietary palmitate to oleate ratio in humans decreases the leukocyte production of pro-inflammatory cytokines and muscle expression of redox-sensitive genes.  J Nutr Biochem. 2015;26:1599-606, PMID 26324406.

ien CL, Bunn JY, Stevens R, Bain J, Ikayeva O, Crain K, Koves TR, Muoio DM.  Dietary intake of palmitate and oleate has broad impact on systemic and tissue lipid profiles in humans.  Am J Clin Nutr. 2014;99:436-45, PMID 24429541.

Kien CL, Bunn JY, Poynter ME, Stevens R, Bain J, Ikayeva O, Fukagawa NK, Champagne CM, Crain KI, Koves TR, Muoio DM.  A lipidomics analysis of the relationship between dietary fatty acid composition and insulin sensitivity in young adults.  Diabetes. 2013;62:1054-63 PMID 23238293.

Koves TR, Sparks LM, Kovalik JP, Mosedale M, Arumugam R, DeBalsi KL, Everingham K, Thorne L, Phielix E, Meex RC, Kien CL, Hesselink MKC, Schrauwen P, Muoio DM.  PPARgamma coactivator-1alpha contributes to exercise-induced regulation of intramuscular lipid droplet programming in mice and humans.  J Lipid Res. 2013;54:522-34, PMID 23175776.

Kien CL, Bunn J, Tompkins CL, Dumas JA, Crain KI, Ebenstein DB, Koves TR, Muoio DM.  Substituting dietary monounsaturated fat for saturated fat is associated with increased daily physical activity and resting energy expenditure and with changes in mood.  Am J Clin Nutr. 2013;97:689-97, PMID 23446891.

Kien CL, Everingham KI, D Stevens R, Fukagawa NK, Muoio DM: Short-term effects of dietary fatty acids on muscle lipid composition and serum acylcarnitine profile in human subjects.  Obesity (Silver Spring). 2011;19:305-11, PMID 20559306.

Kovalik JP, Slentz D, Stevens RD, Kraus WE, Houmard JA, Nicoll JB, Lea-Currie YR, Everingham K, Kien CL, Buehrer BM, Muoio DM.  Metabolic remodeling of human skeletal myocytes by cocultured adipocytes depends on the lipolytic state of the system.  Diabetes. 2011;60:1882-93, PMID 21602515.

Kien CL, Blauwiekel R, Bunn JY, Jetton TL, Frankel WL, Holst JJ: Cecal infusion of butyrate increases intestinal cell proliferation in piglets. J Nutr. 2007;
137:916–22, PMID 17374654. 

Kien CL, Schmitz-Brown M, Solley T, Sun D, Frankel WL.  Increased colonic luminal synthesis of butyric acid is associated with lowered colonic cell proliferation in piglets.  J Nutr. 2006;136:64-9, PMID 16365060. 

For a complete list of Dr. Kien's publications, please visit Pub Med.