University of Vermont

College of Medicine

Department of Medicine

Endocrinology, Diabetes & Metabolism

Bio for Tom Jetton, Ph.D.
Tom Jetton, Ph.D.

Tom Jetton, Ph.D.

Associate Professor, Department of Medicine, Division of Endocrinology, Diabetes and Metabolism


Contact Information
E-mail: tjetton@uvm.edu
Office Location:
UVM Colchester Research Facility, 208 South Park Drive, Rm 110E, Colchester, VT 05446

Education

B.S. in Biology, University of North Carolina at Charlotte, Charlotte, NC, 1980

 

M.S. in Biology, Western Carolina University, Cullowhee, NC, Thesis Advisor, Dr F.W. Harrison, 1983

 

Ph.D. in Biology, Vanderbilt University, Nashville, TN, Dissertation Advisor: Dr B.J. Bogitsh, 1990

 

Postdoctoral Fellow in Molecular Physiology/Biophysics, Vanderbilt University, Nashville, TN, Mentor, Dr M.A. Magnuson, 1990-1993

Academic Interests

Developmental and regeneration biology of the pancreatic islets
 
Glucose homeostasis
 
Beta cell mass compensation

Expertise

Molecular, cellular, and physiological approaches to study the regulation of pancreatic beta cell growth and survival.

Academic Appointments

Associate Professor,  Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Vermont College of Medicine, Burlington, VT, 1999-present

Research Grants

ß-cell Compensation in Partial Pancreatectomy Mice (Leahy, PI)
9/1/10-8/31/14
Jetton, Co-I
NIH/NIDDK

Beta-cell PPAR gamma signaling in fat fed mice (Leahy, PI)
1/1/10-12/31/12
Jetton, Co-I
ADA Basic Research Grant

PPARy and uterine vascular dysfunction in diabetic pregnancy (Gokina, PI)
9/1/08-7/30/12
Jetton, Co-I
NIH/NHLBI

Additive effects of TZD and DPP-4 inhibitor therapy on beta-cell mass and function (Leahy, PI)
9/1/10-2/25/13
Jetton, Co-I
Takeda Pharmaceuticals Research Grant


Awards and Honors

Phi Kappa Phi Honor Society, 1984

Publications (Peer Reviewed)

Jetton TL, Liu YQ, Trotman WE, Nevin PW, Sun X-J, Leahy JL. Enhanced insulin receptor substrate-2 expression and activation of protein kinase B/Akt in the regenerating pancreatic duct epithelium of 60% partial pancreatectomy rats. Diabetologia. 2001; 44:2056-2065.

Jetton TL, Lausier J, LaRock K, Trotman WE, Larmie B, Habibovic A, Peshavaria M, Leahy JL. Mechanisms of compensatory ß-cell growth in insulin resistant rats: Roles of Akt kinase. Diabetes. 2005; 54:2294-2304.

Peshavaria M, Larmie BL, Lausier J, Satish B, Habibovic A, Roskens V, LaRock K, Everill B, Leahy JL, Jetton TL. Regulation of pancreatic ß-cell regeneration in the normoglycemic 60% partial pancreatectomy mouse. Diabetes. 2006; 55:3289-3298.

Jetton TL, Everill B, Lausier J, Roskens V, Habibovic A, LaRock K, Gokin A, Peshavaria M, Leahy JL. Enhanced ß-cell mass without increased proliferation following chronic mild glucose infusion. Am J Physiol Endocrinol Metab. 2008; 294:E679-687.


Lausier J, Diaz WC, Roskens V, LaRock K, Herzer K, Fong CG, Latour M, Peshavaria M, Jetton TL. Vagal control of pancreatic ß-cell proliferation. Am J Physiol Endocrinol Metab. 2010; 299:E786-E793.

For a complete list of Dr. Jetton's publications, please visit Pub Med