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Cardiovascular Medicine

Bio for Peter Spector, M.D.
Peter Spector, M.D.

Peter Spector, M.D.

Professor of Medicine
Cardiovascular Medicine, Department of Medicine


Contact Information
E-mail: Peter.Spector@uvm.edu
Office Location:
Medicine, McClure Wing, Rm 1060

Education

Medical School - Albert Einstein College of Medicine, New York, NY

Research Interests

Dr. Spector's research has focused on three areas:  Mapping of Atrial Fibrillation, the role of the autonomic nervous system in the genesis and treatment of Atrial Fibrillation, and biophysics of ablation.

Academic Appointments

Professor of Medicine, University of Vermont, Burlington, VT

Publications

Representative Publications from a total of 21


Spector PS, Curran ME, Zou A, Keating MT, Sanguinetti MC.  Fast inactivation causes rectification of the  Ikr channel.  J Gen  Physiol 1996; 107:611-619.


Sanguinetti MC, Curran ME, Zou A, Shen J, Spector PS, Atkinson DL, Keating MT.  Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel.  Nature 1996; 384:80-83.


Spector PS, Curran ME, Keating MT, Sanguinetti MC.  Class III antiarrhythmic drugs block HERG, a human cardiac delayed rectifier K+ Channel.  Open-channel block by methanesulfonanilides.  Circ Res 1996; 78:499-503.


Nakagawa H, Shah N, Matsudaira K, Overholt E, Chandrasekaran K, Beckman KJ, Spector PS, Calame JD, Rao A, Hasdemir C, Otomo K, Wang Z, Lazzara R, Jackman WM.  Characterization of reentrant circuit in macroreentrant right atrial tachycardia after surgical repair of congenital heart disease. Isolated channels between scars allow “focal” ablation.  Circulation 2001; 103:699-709.


Lustgarten DL, Spector PS.  Ablation strategies reflect evolving concepts of atrial fibrillation mechanisms. J Electrocardiol 2001; 34:129-134.


Sun Y, Arruda MS, Otomo K, Beckman KJ, Nakagawa H, Calame D, Po S, Spector PS, Lustgarten D, Herring L, Lazzara R, Jackman WM.  Coronary sinus-ventricular accessory connections producing posteroseptal and left posterior accessory pathways: Incidence and electrophysiological identification.  Circulation  2002; 106:1363-1367.


Nakagawa H, Aoyama H, Beckman KJ, S. Po S, Wu R, Lockwood D , Spector P, Calame JD, Lustgarten DL, Herring L, Hasdemir C, Singh D, Lazzara R, Jackman WM.  Relation between pulmonary vein firing and extent of left atrial–pulmonary vein connection in patients with atrial fibrillation.  Circulation  2004; 109:1523-1529.


Lustgarten DL, Bell S, Hardin N, Calame D, Spector PS.  Safety and efficacy of epicardial cryoablation in a canine model.  Heart Rhythm  2005; 2:82-90.


Spector PS, Noori AM, Hardin NJ, Calame JD, Bell SP, Lustgarten DL. Pulmonary Vein Encircling Ablation Alters the Atrial Electrophysiologic Response to Autonomic Stimulation.  J Interv Card Electrophysiol 2006 Nov;17(2):119-25.

 

Lustgarten DL, Spector PS. Ablation using irrigated radiofrequency: a hands-on guide. Heart Rhythm 2008 Jun;5(6):899-902.

 

Thompson N, Lustgarten D, Mason B, Mueller E, Calame J, Bell S, Spector P. The Relationship between Tissue Temperature, Microbubble Formation and Steam Pops.  Pacing and Clinical Electrophysiology 2009 Jul;32(7):831-2.

 

Spector P, Reynolds M, Calkins H, Sondhi M, Xu Y, Martin A, Williams C, Sledge I.  Meta-analysis of Ablation of Atrial Flutter and Supraventricular Tachycardia; American Journal of Cardiology, 2009 Sept.1;104(5):671-7.

 

Calkins H, Reynolds M, Spector P, Sondhi M, Xu Y, Martin A, Williams C, Sledge I.  Treatment of Atrial Fibrillation with Anti-arrhythmic Drugs or Radio Frequency Ablation: Two Systematic Literature Reviews and Meta-analyses; Circulation EP, June 2009. 

 

Lustgarten DL, Calame S, Crespo EM, Calame J, Lobel R, Spector PS. Electrical resynchronization induced by direct His-bundle pacing.  Heart Rhythm, October 2009.

 

Bates JHT, Spector PS. On the Ill-conditioned Nature of the Intracardiac Inverse Problem. 31st Annual International Conference of the IEEE EMBS Minneapolis, Minnesota, USA, September 2-6, 2009.

 

Habel N, Znojkiewicz P, Thompson N, Müller JG, Mason B, Calame J, Calame S,  Sharma S, Mirchandani G, Janks D, Bates J, Noori A, Karnbach A, Lustgarten DL, Sobel BE, Spector P. The temporal variability of dominant frequency and complex fractionated


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