University of Vermont

College of Medicine

Department of Medicine

Cardiovascular Medicine

Bio for Peter Spector, M.D.
Peter Spector, M.D.

Peter Spector, M.D.

Professor of Medicine
Cardiovascular Medicine, Department of Medicine


Contact Information
E-mail: Peter.Spector@uvm.edu
Office Location:
Medicine-Cardiology, McClure Wing, 111 Colchester Avenue, Burlington, VT 05401

Education

Medical School - Albert Einstein College of Medicine, New York, NY

Research Interests

Dr. Spector's lab focuses on atrial fibrillation.  The work is largely along two parallel lines of investigation:  wave dynamics in multi-wavelet re-entry, and mapping and ablation of AF.  This work has resulted in 9 U.S. patent applications and the formation of an educational and R&D software company called "VisibleEP."

Academic Appointments

Professor of Medicine, University of Vermont, Burlington, VT

Publications

Representative Publications from a total of 31

Carrick RT, Benson B, Habel N, Bates ORJ, Bates JHT, Spector PS. Ablation of multiwavelet re-entry guided by circuit-density and distribution maximizing the probability of circuit annihilation. Circ Arrhythm Electrophysiol. 2013;6:1229-35.

Spector PS, Correa de Sa DD, Tischler ES, Thompson NC, Habel N, Stinnett-Donnelly J, Benson BE, Bielau P, Bates JHT.  Ablation of multi-wavelet re-entry: general principles and in silico analyses.  Europace. 2012;14:v106-v111. 

Correa de Sa D, Thompson N, Stinnett-Donnelly J, Znojkiewicz P, Habel N, Müller JG, Bates J, Buzas JS, Spector PS.  Electrogram fractionation: The relationship between spatio-temporal variation in tissue excitation and electrode spatial resolution. Circ Arrhythm Electrophysiol. 2011;4(6):909-16.  

Stinnett-Donnelly  JM, Thompson N, Habel N, Petrov-Kondratov V, Correa de Sa DD, Bates JH, Spector PS.  Effects of electrode size and spacing on the resolution of intracardiac electrograms. Coron Artery Dis. 2012;23(2):126-32. 

Spector PS, Habel N, Sobel BE, Bates JH.  Emergence of complex behavior: An interactive model of cardiac excitation provides a powerful tool for understanding electric propagation. Circ Arrhythm Electrophysiol. 2011;4(4):586-91.  

Habel N, Müller JG, Znojkiewicz P, Thompson N, Calame J, Calame S, Noori A, Gallo A, Lustgarten DL, Sobel BE, Spector PS.  The impact of pharmacologic sympathetic and parasympathetic blockade on atrial electrogram characteristics in patients with atrial fibrillation.  Pacing Clin Electrophysiol. 2011;34(11):1460-7.

Habel N, Znojkiewicz P, Thompson N, Muller JG, Mason B, Calame J, Calame S, Sharma S, Mirchandani G, Janks D, Bates J, Noori A, Karnbach A, Lustgarten DL, Sobel BE, Spector P.  The temporal variability of dominant frequency and complex fractionated atrial electrograms constrains the validity of sequential mapping in human atrial fibrillation.  Heart Rhythm. 2010;7(5):586-93. 

Calkins H, Reynolds MR, Spector P, Sondhi M, Xu Y, Martin A, Williams CJ, Sledge I. Treatment of atrial fibrillation with antiarrhythmic drugs or radiofrequency ablation: Two systematic literature reviews and meta-analyses. Circ Arrhythmia Electrophysiol, 2009;2(4),349-61.

Bates JHT and Spector PS. On the ill-conditioned nature of the intracardiac inverse problem. Conf Proc IEEE Eng Med Biol Soc. 2009;2009:3929-31.

Spector PS, Noori AM, Hardin NJ, Calame JD, Bell SP, Lustgarten DL.  Pulmonary vein encircling ablation alters the atrial electrophysiologic response to autonomic stimulation.  J Interv Card Electrophysiol. 2006;17(2):119-25.

Nakagawa H, Aoyama H, Beckman KJ, Po SS, Wu R, Lockwood D, Spector P, Calame JD, Lustgarten DL, Herring L, Hasdemir C, Singh D, Lazzara R, Jackman WM.  Relation between pulmonary vein firing and extent of left atrial-pulmonary vein connection in patients with atrial fibrillation.  Circulation. 2004;109(12):1523-9.

Sun Y, Arruda MS, Otomo K, Beckman KJ, Nakagawa H, Calame J, Po S, Spector PS, Lustgarten D, Herring L, Lazzara R, Jackman WM. Coronary sinus-ventricular accessory connections producing posteroseptal and left posterior accessory pathways: Incidence and electrophysiological identification.  Circulation. 2002;106:1362-7. 

Nakagawa H, Shah N, Matsudaira K, Overholt E, Chandrasekaran K, Beckman KJ, Spector PS, Calame JD, Rao A, Hasdemir C, Otomo K, Wang Z, Lazzara R, Jackman WM.  Characterization of reentrant circuit in macroreentrant right atrial tachycardia after surgical repair of congenital heart disease. Isolated channels between scars allow “focal” ablation.  Circulation. 2001;103:699-709.

Sanguinetti MC, Curran ME, Zou A, Shen J, Spector PS, Atkinson DL, Keating MT.  Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel.  Nature. 1996;384(6604):80-3.  

Spector PS, Curran ME, Zou A, Keating MT, Sanguinetti MC.  Fast inactivation causes rectification of the Ikr channel.  J Gen Physiol. 1996;107(5):611-9. 

Sanguinette MC, Curran ME, Spector PS, Keating MT.  Spectrum of HERTG K+- Channel dysfunction in inherited cardiac arrhythmias.  Proc Natl Acad Sci USA. 1996;93(5):2208-12.

Spector PS, Curran ME, Keating MT, Sanguinetti MC.  Class III antiarrhythmic drugs block HERG, a human cardiac delayed rectifier K+ channel.  Open-channel block by methanesulfonanilides.  Circ Res. 1996;78(3):499-503.