University of Vermont

College of Medicine

Department of Medicine

Cardiovascular Medicine

Bio for Robert Kelm, Ph.D.
Robert Kelm, Ph.D.

Robert Kelm, Ph.D.

Associate Professor of Medicine
Associate Professor of Biochemistry


Contact Information
E-mail: Robert.Kelm@uvm.edu
Office Location:
Colchester Research Facility, Room 165

Expertise

Dr. Kelm received his Ph.D. in Biochemistry from the University of Vermont College of Medicine in 1991. He then joined Haematologic Technologies, Inc. as a Scientist and advanced to the position of Director of Assay Development. Dr. Kelm returned to academia in 1994 as a Research Fellow in the Department of Biochemistry and Molecular Biology at the Mayo Clinic where he rose to the rank of Assistant Professor. Dr. Kelm joined the UVM faculty as an Assistant Professor in the Department of Medicine in 2001 and received a secondary in the Department of Biochemistry in 2002. Dr. Kelm was promoted to Associate Professor with tenure in 2006.

Publications

Wang, S.X., Elder, P.K., Zheng, Y., Strauch, A.R., and Kelm, R.J., Jr. (2005). Cell cycle-mediated regulation of smooth muscle a-actin gene transcription in fibroblasts and vascular smooth muscle cells involves multiple adenovirus E1A-interacting cofactors. J. Biol. Chem. 280:6204-6214.

Representative Publications from a total of 42

Knapp, A. M., Ramsey, J. E., Wang, S. X., Godburn, K. E., Strauch, A. R., and Kelm, R. J., Jr. (2006) Nucleoprotein interactions governing cell type-specific repression of the mouse smooth muscle alpha-actin promoter by single-stranded DNA-binding proteins Pur-alpha and Pur-beta. J. Biol. Chem. 281:7907-7918

Ramsey, J. E., Daugherty, M. A., and Kelm, R. J., Jr. (2007) Hydrodynamic studies on the quaternary structure of recombinant mouse Pur-beta. J. Biol. Chem. 282:1552-1560

Knapp, A. M., Ramsey, J. E., Wang, S. X., Strauch, A. R., and Kelm, R. J., Jr. (2007) Structure-function analysis of mouse Pur-beta II: Conformation altering mutations disrupt single-stranded DNA and protein interactions crucial to smooth muscle alpha-actin gene repression.  J. Biol. Chem. 282:35899-35909

Zhang, A., David, J. J., Subramanian, S. V., Liu, X., Fuerst, M. D., Zhao, X., Leier, C. V., Orosz, C. G., Kelm, R. J., Jr., and Strauch, A. R. (2008) Serum response factor neutralizes Pur-alpha and Pur-beta-mediated repression of the fetal vascular smooth muscle alpha-actin gene in stressed adult cardiomyocytes.  Am. J. Physiol. Cell. Physiol. 294:C702-C714

Ramsey, J. E. and Kelm, R. J., Jr. (2009) Mechanism of strand-specific smooth muscle alpha-actin enhancer interaction by purine-rich element binding protein B (Pur-beta). Biochemistry 48:6348-6360

van Rooij, E., Quiat, D., Johnson, B. A., Sutherland, L. B., Qi, X., Richardson, J. A., Kelm, R. J., Jr., and Olson, E. N. (2009) A family of microRNAs encoded by myosin genes governs myosin expression and muscle performance. Dev. Cell 17:662-673

Rumora, A. E., Steere, A. N, Ramsey, J. E., Knapp, A. M., Ballif, B. A., and Kelm, R. J. Jr. (2010) Isolation and characterization of the core single-stranded DNA-binding domain of purine-rich element binding protein B (Pur-beta). Biochem. Biophys. Res. Commun. 400:340-345

For a complete list of publications go to http://scholar.google.com/citations?user=xlTkAdcAAAAJ&hl=en
Rumora AE, Wang SX, Ferris LA, Everse SJ, Kelm RJ Jr (2013) Structural basis of multisite single-stranded DNA recognition and ACTA2 repression by purine-rich element binding protein B (Purß). Biochemistry 52(26): 4439-50

David JJ, Subramanian SV, Zhang A, Willis WL, Kelm RJ Jr, Leier CV, Strauch AR (2012) Y-box binding protein-1 implicated in translational control of fetal myocardial gene expression after cardiac transplant. Exp Biol Med (Maywood) 237(5): 593-607.

Gurha P, Abreu-Goodger C, Wang T, Ramirez MO, Drumond AL, van Dongen S, Chen Y, Bartonicek N, Enright AJ, Lee B, Kelm RJ Jr, Reddy AK, Taffet GE, Bradley A, Wehrens XH, Entman ML, Rodriguez A (2012) Targeted deletion of microRNA-22 promotes stress-induced cardiac dilation and contractile dysfunction. Circulation 125(22): 2751-61.

Rumora AE, Steere AN, Ramsey JE, Knapp AM, Ballif BA, Kelm RJ Jr (2010) Isolation and characterization of the core single-stranded DNA-binding domain of purine-rich element binding protein B (Purß). Biochem Biophys Res Commun 400(3): 340-5.

French CJ, Zaman AK, Kelm RJ Jr, Spees JL, Sobel BE (2010) Vascular rhexis: loss of integrity of coronary vasculature in mice subjected to myocardial infarction. Exp Biol Med (Maywood) 235(8): 966-73.

Kollander R, Solovey A, Milbauer LC, Abdulla F, Kelm RJ Jr, Hebbel RP (2010) Nuclear factor-kappa B (NFkappaB) component p50 in blood mononuclear cells regulates endothelial tissue factor expression in sickle transgenic mice: implications for the coagulopathy of sickle cell disease. Transl Res 155(4): 170-7.
Hebbel RP, Vercellotti GM, Pace BS, Solovey AN, Kollander R, Abanonu CF, Nguyen J, Vineyard JV, Belcher JD, Abdulla F, Osifuye S, Eaton JW, Kelm RJ Jr, Slungaard A (2010) The HDAC inhibitors trichostatin A and suberoylanilide hydroxamic acid exhibit multiple modalities of benefit for the vascular pathobiology of sickle transgenic mice. Blood 115(12): 2483-90.

David JJ, Subramanian SV, Zhang A, Willis WL, Kelm RJ Jr, Leier CV, Strauch AR. Y-box binding protein-1 implicated in translational control of fetal myocardial gene expression after cardiac transplant. Exp Biol Med (Maywood). 2012 May 1;237(5):593-607

Gurha P, Abreu-Goodger C, Wang T, Ramirez MO, Drumond AL, van Dongen S, Chen Y, Bartonicek N, Enright AJ, Lee B, Kelm RJ Jr, Reddy AK, Taffet GE, Bradley A, Wehrens XH, Entman ML, Rodriguez A. Targeted deletion of microRNA-22 promotes stress-induced cardiac dilation and contractile dysfunction. Circulation. 2012 Jun 5;125(22):2751-2761

Rumora AE, Steere AN, Ramsey JE, Knapp AM, Ballif BA, Kelm RJ Jr. Isolation and characterization of the core single-stranded DNA-binding domain of purine-rich element binding protein B (Purß). Biochem Biophys Res Commun. 2010 Sep 24;400(3):340-345

van Rooij E, Quiat D, Johnson BA, Sutherland LB, Qi X, Richardson JA, Kelm RJ Jr, Olson EN. A family of microRNAs encoded by myosin genes governs myosin expression and muscle performance. Dev Cell. 2009 Nov;17(5):662-673

Ramsey JE, Kelm RJ Jr. Mechanism of strand-specific smooth muscle a-actin enhancer interaction by purine-rich element binding protein B (Purß). Biochemistry. 2009 Jul 14;48(27):6348-6360

Zhang A, David JJ, Subramanian SV, Liu X, Fuerst MD, Zhao X, Leier CV, Orosz CG, Kelm RJ Jr, Strauch AR. Serum response factor neutralizes Pur alpha- and Pur beta-mediated repression of the fetal vascular smooth muscle alpha-actin gene in stressed adult cardiomyocytes. Am J Physiol Cell Physiol. 2008 Mar;294(3):C702-714

Knapp AM, Ramsey JE, Wang SX., Strauch AR, Kelm RJ Jr. Structure-function analysis of mouse Pur beta II: Conformation altering mutations disrupt single-stranded DNA and protein interactions crucial to smooth muscle alpha-actin gene repression. J Biol Chem. 2007 Dec 7;282(49):35899-35909

Ramsey JE, Daugherty MA, Kelm RJ Jr. Hydronamic studies on the quarternary structure of recombinant mouse Pur beta. J Biol Chem. 2007 Jan 19;282(3):1552-1560