University of Vermont

College of Medicine

Laboratory for Clinical Biochemistry Research

Clinical Studies

The LCBR research portfolio includes molecular and genetic Epidemiology family-based genetic research, clinical trials and basic studies using murine models of disease. Listed below are some of the many studies that we are involved with.

Active

Status: Active
Exercise Training for the Prevention of Cancer Thrombosis (EXPECT) Pilot
Primary Investigator: Susan Lakoski
Purpose: A research study that will help us understand the importance of exercising during chemotherapy to prevent blood clots among cancer patients.
ClinicalTrials.gov Identifier: NCT01853202

Contact: Elizabeth Eldridge (802) 656-2178
More Information: Exercise Training for the PrEvention of Cancer Thrombosis (EXPECT) Pilot
Institution Number: M13-171, VCC 1220

Status: Active
An Exercise Training and Behavioral Weight Loss Program After an Acute Blood Clot: TRAIN ABC
Primary Investigator: Susan Lakoski

Purpose: Patients after an acute blood clot in the veins are at risk for leg-related complications such as pain, swelling, and immobility. In addition, the occurrence of blood clots can have major implications for personal health including weight gain, blood clot recurrence and impairment in cardiovascular functioning. The goal of this study is to determine whether aerobic exercise training is a therapeutic strategy to offset risk factors for recurrent blood clots or leg complications.
ClinicalTrials.gov Identifier: NCT01864447

Contact: Amy Berkman (802) 656-1970
More Information: An Exercise Training and Behavioral Weight Loss Program After an Acute Blood Clot: TRAIN ABC
Institution Number: M13-219

Status: Active
Translational Research on Alcohol, Immunodeficiency and Aging in COMpAAAs
Primary Investigator: Russell Tracy
Purpose: This study collects and banks longitudinal samples (blood, urine and DNA) with which to characterize the interaction and physiologic impact of alcohol and age–related multimorbidity and polypharmacy on immune dysfunction and organ system injury among HIV+ initiating cART and demographically and behaviorally similar uninfected individuals.
Status: Active
Vitamin D to Prevent Type 2 Diabetes (D2d)
Primary Investigator: Russell Tracy
Purpose:This is a Multicenter, randomized (1:1), double-masked, placebo-controlled, primary prevention parallel-group clinical trial with 2 arms (oral daily vitamin D vs. placebo) in participants at high risk for diabetes (with pre-diabetes) who will be followed for an average of 3 years after randomization for incident diabetes. The aim is to assess whether, in participants with pre-diabetes, oral daily vitamin D3 supplementation reduces the rate of progression from pre-diabetes to clinical diabetes.
Status: Active
Cardiovascular Health Study
Primary Investigator: Russell Tracy
Purpose:The major goal of this project is to determine cardiovascular disease risk factors in a longitudinal study of the elderly. The Vermont component is to perform all blood tests on the cohort (n=5000). Ongoing since 1988
Status: Active
Multi Ethnic Study of Atherosclerosis (MESA)
Primary Investigator: Russell Tracy
Purpose: The major goal of this project is to provide laboratory-support for non-standard tests in areas such as hemostasis, lipoprotein metabolism, inflammation, genetic markers in a multi center, longitudinal epidemiological study of the incidence and progression of subclinical CVD.
More Information: http://www.mesa-nhlbi.org/
Status: Active
Reasons for Geographic and Racial Differences in Stroke (REGARDS)
Primary Investigator: Mary Cushman
Purpose:Analytes related to stroke risk in a 30,000-person national observational study are measured to assess reasons for geographic and racial differences in stroke risk. All participant evaluations will take place in participants' homes.
More Information: http://www.regardsstudy.org/
Status: Active
Epidemiology of Venous Thrombosis and Pulmonary Embolism
Primary Investigator: Mary Cushman
Purpose:A renewal of the Longitudinal Investigation of Thromboembolism Etiology (LITE), this study of venous thromboembolism (VTE) in the Atherosclerosis Risk in Communities (ARIC) Study and Cardiovascular Health Study (CHS) cohorts, comprises 21,680 participants followed for two decades. LITE’s overall objective is to identify risk factors for deep venous thromboembolism (DVT) and pulmonary embolism (PE), in order to better understand the etiology and possible prevention of VTE
Status: Active
Exceptional Aging: 12 Year Trajectories to Function
Primary Investigator: Mary Cushman
Purpose:This study will determine the likelihood of maintaining function, identify the trajectories that distinguish those destined to do well, land define the importance, independence and interactions of physiologic predictors of functional aging in CHS participants over 80 years of age
Status: Active
Impact of Disordered Mineral Metabolism on Stroke and Cognitive Impairment
Primary Investigator: Nancy Jenny
Purpose:An ancillary study utilizing the REGARDS (Reasons for Geographic and Racial Difference in Stroke) cohort, the goals of this study are to measure a variety of biomarkers of mineral metabolism and to determine their associations with stroke and cognitive impairment in U.S. whites and blacks.
Status: Active
Stress, Gene-Environment Interaction and Cardiovascular Disease
Primary Investigator: Nancy Jenny
Purpose:This study investigates long-term associations of the stress response with social/psychosocial antecedents and cardiovascular-related outcomes, as well as modifications of the stress response by genetic variations in the glucocorticoid receptor (GR) gene, and links between epigenetic changes the GR gene, social/psychosocial exposures, and the stress response.
Status: Active
Regional and Racial Differences in Hemostasis and Risk of Stroke and Heart Disease
Primary Investigator: Neil Zakai
Purpose:An investigation into the regional and racial difference in stroke incidence as mediated by differences in coagulation proteins.
Status: Active
T Reg Cells in Myocarditis
Primary Investigator: Sally Huber
Purpose:This project studies the role of T regulatory cells in coxsackievirus B3 induced myocarditis.

Completed

Status: Completed
Ginko Evaluation of Memory Study
Primary Investigator: Russell Tracy
Purpose: The goal of this project is to enroll and follow 2000 participants in randomized trial of 240 mg of ginkgo biloba as compared to placebo in men and women, median age of 80.
Status: Completed
LeDucq Foundation
Primary Investigator: E. Bovill
Purpose: An international network focused on the role of thrombosis in cardiovascular research. The program of activities will center on the pathways that stimulate and control thrombin generation and the consequences of thrombin generation in both arterial and venous disease.
Status: Completed
MESA Family Study
Primary Investigator: Russell Tracy
Location: Laboratory Center
Purpose:The goal of this study is to locate and identify genes contributing to the genetic risk of subclinical cardiovascular disease (CVD) and evaluate the impact of lifestyle and environment on the expression of these genetic components of CVD.
Status: Completed
Renal REGARDS
Primary Investigator: Mary Cushman
Purpose:This study will explore the role of anemia and renal function on stroke outcomes in a 30,000-person cohort.
Status: Completed
Dynamics of Health, Aging, Body Composition
Primary Investigator: Russell Tracy
Purpose:This study is designed to characterize the aging-related changes that occur in body composition in older men and women, and identify these changes with ability and disability as well as diseases of old age such as Cardiovascular Disease.
More Information: http://www.grc.nia.nih.gov/branches/leps/healthabc/
Status: Completed
Familial Aggregation & Natural History of Sleep Apnea
Primary Investigator: Russell Tracy
Purpose:The goal of this project continuation is to further investigate the genetic and etiologic bases for obstructive Sleep Apnea in a unique, radically diverse family cohort (n=2200) who have undergone overnight sleep studies.
Status: Completed
Genetics of Coronary and Aortic Clacification (GENAC)
Primary Investigator: Russell Tracy
Purpose: The goal of this proposal is to identify familial, genetic, and non-genetic factors that establish susceptibility to atherosclerosis and the inflammatory response.
Status: Completed
Azithromycin and Coronary Events Study
Primary Investigator: Russell Tracy
Purpose: The main goal of this project is to study the association of infection with Chlamydia pneumoniae and cardiovascular disease. Studies of serologic markers of inflammation will be conducted to help identify individuals who may be at higher risk for disease
Status: Completed
Behavioral and Immunological Factors in Coronary Disease
Primary Investigator: Russell Tracy
Purpose: The major goal of this project is to investigate the impact of psychosocial factors such as depressive disorders and acute mental stress in the clinical progression of coronary artery disease (CAD) through the measurements of immunological parameters..
Status: Completed
ACE Inhibition and Novel Cardiovascular Risk Factors
Primary Investigator: Russell Tracy
Purpose: The major goal of this project is to conduct a cross-over double-blind randomized controlled trial in high risk patients to gain more insight into the biological mechanisms by which ACE inhibitors may improve clinical outcomes. The results of this trial will help identify patients who will most likely benefit from ACE inhibition and will also provide novel indications for use of ACE inhibitors for conditions where the activation of inflammation may play a causal role.
Status: Completed
Molecular Epidemiology of MI and Stroke in Older Adults
Primary Investigator: Russell Tracy
Purpose:This proposal links advances in thrombosis and inflammation biology, large-scale human genomics, and population and statistical genetics, with the unique resources of the Cardiovascular Health Study to enhance the sensitivity and specificity of detecting the genetic determinates of cardiovascular disease.
Status: Completed
Epidemiology of Vascular Inflammation and Atherosclerosis
Primary Investigator: Russell Tracy
Purpose:The main hypothesis of this project is that variation in vascular cell biology is related to the population variation in atherosclerosis. The goal is to ascertain new cellular phenotypes and determine their distributions and cross-sectional associations with atherosclerosis by exploring the innate immune response, the adaptive immune response, and vessel integrity using a subset of participants from the large epidemiological study, MESA.
Status: Completed
Prospective Study of Atherosclerosis, Clinical Cardiovascular, and Long-Term Exposure to Ambient Particulate Matter and Other Air Pollutants in a Multi-Ethnic Cohort (EPA)
Primary Investigator: Russell Tracy
Purpose:The primary goal of this project is to prospectively assess the relationship between individual exposure to air pollution and the progression of subclinical atherosclerosis in a multi-ethnic cohort.
Status: Completed
Endothelial Dysfunction, Biomarkers, and Lung Function
Primary Investigator: Russell Tracy
Purpose:This proposal plans to study the hypothesis that vascular function is associated with the pathogenesis and progression of subclinical chronic obstructive pulmonary disease (COPD) in part through effects on systemic inflammation.
Status: Completed
Stress, Inflammation & Genetics of Human Longevity
Primary Investigator: Russell Tracy
Purpose:This study uses candidate genes and haplotypes to explore genetic implications on overall survival cardiovascular and cancer-related mortality, and years of healthy life in the Cardiovascular Health Study cohort.
Status: Completed
Epidemiology of Venous Thrombosis and Pulmonary Embolism
Primary Investigator: Mary Cushman
Purpose: The current goals are to validate additional cases of deep vein thrombosis and pulmonary embolism in the Atherosclerosis Risks in Communities Study and the Cardiovascular Health Study, and to explore biochemical risk factors for thrombosis, as well as the associations of diet and frailty with thrombosis.
Status: Completed
Serum Sex Hormone Levels and Subclinical Atherosclerosis
Primary Investigator: Mary Cushman
Purpose: The role of this laboratory is to organize blood sample logistics and participate in analysis of data associating sex hormone levels with subclinical atherosclerosis..
Status: Completed
Explaining Socioeconomic Differences in Cardiovascular Risk: The Role of Stress, Inflammation, and Hemostasis
Primary Investigator:Mary Cushman
Purpose: This project will focus on the assessment of the interrelation of stress, inflammation and hemostasis in association with cardiovascular disease risk and subclinical atherosclerosis in the MESA study..
Status: Completed
Novel Markers of Inflammation and Atherosclerosis (AHA)
Primary Investigator: Nancy Jenny
Purpose: The major goal of this project is to study associations between different aspects of the inflammatory response and the development and progression of atherosclerosis in two cohorts including one comprised of middle-aged and elderly individuals of different racial/ethnic backgrounds.
Status: Completed
Surface Dependent Reactions in Thrombosis and Thrombolysis
Primary Investigator: E. Bovill
Purpose: A continuing project to search by genetic linkage analysis for a second component in a large Protein C deficient, thrombophilic kindred that increases the risk of thrombosis.
Status: Completed
Hemostasis and Thrombosis Program for Academic Trainees
Primary Investigator: K. Mann
Purpose: The major goal of this project is to train post-graduate fellows (MD and PhD) to conduct clinical and basic research in the fields of thrombosis and hemostasis.
Status: Completed
CD1 and gd+ Cells in Viral Myocarditis
Primary Investigator: Sally Huber
Purpose: CD1 is a major histocompatibility complex (MHC) I - like molecule important in infectious diseases. Coxsackievirus B3 (CVB3) infections induce myocarditis in CD1+ but not in CD1- mice. Preliminary evidence indicates that T cells expressing the gd+T cell receptor are CD1 restricted. The specific aims of this grant are to 1) determine CD1 expression in pathogenic and non-pathogenic CVB3 infections and the role of lipid or peptide antigens in the CD1- restricted gd+ T cell response and 2) determine whether gd+ cells interact with CD4+ Th2 cells through CD1.
Status: Completed
Molecular Mechanisms of the Th1/Th2 Development: Mechanisms of Coxsackievirus-induced CD4+ TH1 Cell Bias: role for FasL
Primary Investigator: Sally Huber
Purpose: The Aims of the project are: 1) determine the kinetics of CD4+ d++and T cell infiltration into the myocardium after H3 and H310A1 virus infections, the role of FasL in d++ cell migration into the heart and the relative importance of IFNd and FasL expression in d++ cells in biasing the Th1 response; 2) Determine whether activation of NFAT by virus binding to d++ and CD4+ cells is required for induction of FasL; and 3) determine whether Caspase 8 activity and cleavage of c-FLIP is increased in CVB3 specific Th2 cells more than Th1 cells and whether this makes Th2 cells more susceptible to killing.
Status: Completed
CD4+ T cells promote early atherosclerosis
Primary Investigator: Sally Huber
Purpose: The goal of this project is to 1) evaluate the kinetics of fatty streak development in immunocompetent and C57Bl/6 CD4 knockout mice to determine the exact extent of CD4+ T cell involvement in early atherosclerosis; 2) to use irradiation chimeric mice to determine whether MHC IA and IE molecules regulate early atherosclerosis through CD4+ T cells through direct signal transduction; 3) to determine whether Th1 CD4+ T cell promote atherosclerosis development while Th2 CD4+ cells suppress lesion progression; and 4) if signal transduction is implicated, determine whether IA and IE cross-linking through monoclonal antibodies produce the same effect as presumably cross-linking the CD4-Tcr.
Status: Completed
Sex in Viral Myocarditis
Primary Investigator: Sally Huber
Purpose: The major goal of this application is to evaluate the effects of testosterone and estradiol on the innate and adoptive immune response and lymphocyte survival in vitro and in vivo. Special emphasis is placed on how testosterone increases virus receptor expression and on the effects of virus cross-linking of receptors on signal transduction in lymphocytes and myocytes.

Last modified December 11 2013 10:59 AM