University of Vermont

College of Medicine

Freeman Laboratory - Department of Surgery


Trauma Physiology Laboratory

MRI machine

Traumatic brain injury (TBI) affects approximately 1.7 million patients every year, but there are few options for medical management. We are using state-of-the art experimental techniques in calcium signaling, endothelial function, nitric oxide, and ion channels, to elucidate the molecular mechanisms and functional consequences of vascular responses to traumatic brain injury. Our clinical investigations using structural and functional MRI to study head injured patients are also providing new insight into the nature and progression of disease, as we develop novel therapies to ultimately improve patient outcomes after concussion. This research is closely aligned with the University's Neuroscience, Behavior and Health (NBH) Initiative.

Tram Tran at dissecting microscope

Vascular Biology Techniques

Equipment includes a video microscopy rig for imaging pressurized vessels, and a separate room with two dissection microscopes. We share the use of the nearby UVM Neurosurgery/ Skull Base Laboratory, founded by R.M.P. Donaghy, M.D., who invented many of the techniques of micro-neurosurgery in this same room, four decades ago. Key techniques used by our laboratory:

• Functional studies of pressurized arteries
• High-speed video calcium imaging of intact endothelium
• In vivo magnetic resonance imaging

Our laboratory is located in Given Medical Building, Room E301.


Last modified June 02 2014 11:18 AM