University of Vermont

College of Medicine

Freeman Laboratory - Department of Surgery

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Grants, Collaborations, Abstracts, Publications & Honors


Surgical Research Award - Freeman (PI)
Department of Surgery 07/01/2009 – 06/30/2011 $17,744
Cardiac magnetic resonance imaging to determine left ventricular function in a rodent model of traumatic brain injury

Investigator-Initiated Research Grant - Freeman (PI)
Masimo Corporation 04/01/10 – 4/02/10 $99,873
Evaluation of Masimo noninvasive carboxyhemoglobin testing in ED patients with suspected
carbon monoxide poisoning

Clinical Scientist Research Career Development Award (K08) - Freeman (PI)
NIH/NIGMS 07/01/2011-06/30/2016 $629,600
Endothelial Ca2+ signals and vasodilatory function after traumatic brain injury

Center of Biomedical Research Excellence (COBRE) in Neuroscience Pilot Project - Freeman (PI)
College of Medicine 07/01/2011-06/30/2012 $63,387
Endothelial Ca2+ signals and blood brain barrier permeability following traumatic brain injury

Surgical Research Award – Freeman (PI)
Department of Surgery 07/01/2011 – 06/30/2013 $25,000
A randomized-controlled trial of cognitive therapy to enhance neural repair and improve clinical outcomes following traumatic brain injury


Dept. of the Army - Mann/ Brummel-Zeidins (Co-PIs) (Biochemistry)
Dept. of Defense 3/1/10-2/28/13
Systems Biology for Biological Responses to Severe Hemorrhage $1,864,341

RO1 Naylor (PI) (Psychiatry)
NIH/ NIAMS 7/1/10-6/30/15 $3,263,379
Can therapy alter CNS processing of chronic pain: A longitudinal study

Recent Abstracts

Larson BE, Hannah RM, Sonkusare SK, Wellman GC, Nelson MT, Freeman K. Endothelial Ca2+ signals and vasodilatory function following traumatic brain injury. FASEB J (2011; 25; 641.24 abstract)

Loadholt CD,  Larson BE, Andriakos PG, Boas S, Trahan TE, Tran TL, Falls WA, Hammack SE, Freeman K. Inter-rater reliability of a novel neurobehavioral scale for outcomes assessment in rats following traumatic brain injury. FASEB J (2011; 25; 856.5 abstract)

Larson B, Beal A, Ahari A, Russell S, Freeman K. Beta-adrenergic blockade prevents myocardial oxidative stress due to traumatic brain injury. Annals of Emergency Medicine (2008; 54(3): S142-143 abstract)

Moore HB, Dorf L, Streeter MH, Destigter KK, Crookes B, Leffler S, Freeman K. Airway, breathing, CT scanning: duplicate computed tomography imaging after transfer to trauma center. Journal of Surgical Research (2011;165(2), 341 abstract)


Larochelle N, O'Keefe M, Wolfson D, Freeman K. Cellular technology improves transmission success of pre-hospital electrocardiograms. Am J Emerg Med. 2013 Sep 25. PMID: 24075803

Jones CA, Petrozzino JJ, Hoesche J, Krol EM, Freeman K. Perceptions about time for normalization of international normalized ratio in patients requiring acute warfarin reversal when using fresh-frozen plasma. Am J Emerg Med. 2013 May;31(5):878-9. PMID:23478117

Moore HB, Loomis SB, Destigter KK, Mann-Gow T, Dorf L, Streeter MH, Ebert GM, Crookes BA, Leffler SM, O'Keefe MF, Freeman K. Airway, breathing, computed tomographic scanning: duplicate computed tomographic imaging after transfer to trauma center. J Trauma Acute Care Surg. 2013 Mar;74(3):813-7. PMID: 23425740

Wyne KT, Soltys JN, O'Keefe MF, Wolfson D, Wang HE, Freeman K. King LTS-D use by EMT-intermediates in a rural prehospital setting without intubation availability. Resuscitation. 2012 Jul;83(7):e160-1. PMID: 22484435

Larson BE, Stockwell DW, Boas S, Andrews T, Wellman GC, Lockette W, Freeman K. Cardiac reactive oxygen species after traumatic brain injury. J of Surgical Research (2011, Epub ahead of print). PMID: 22172132

Blum JA, Freeman K, Dart RC, Cooper RJ. Requirements and Definitions in Conflict of Interest Policies of Medical Journals. JAMA, Nov 25, 2009; 302(20):1-5. PMID: 19934424

Freeman K, Feldman JA, Mitchell P, Donovan J, Dyer KS, Eliseo L, White L, and Temin E.  Effects of clinical presentation and initial electrocardiogram on time-to-treatment in emergency department patients with hyperkalemia, Academic Emergency Medicine  (2008, 5(3):239-49). PMID: 18304054

Freeman K, Feldman JA. Cocaine, myocardial infarction, and beta blockade: Time to rethink the equation? Annals of Emergency Medicine (2008, 51:130-134.). PMID: 17933425

Freeman K, Dewitz A, Baker W.  Ultrasound-guided hip arthrocentesis in the emergency department. The American Journal of Emergency Medicine (2007, 25: 80-86). PMID: 17157689

Sandhu H, Carpenter C, Freeman K, Nabors SG, Olson A. Clinical decisionmaking: opening the black box of cognitive reasoning. Annals of Emergency Medicine. 2006 Dec;48(6):713-9. PMID: 17112935

Freeman K, Lerman I, Kranias EG, Bohlmeyer T, Bristow MR, Lefkowitz RJ, Iaccarino G, Koch WJ, and Leinwand LA. Alterations in cardiac adrenergic signaling and calcium cycling have markedly different effects on the progression of hypertrophic cardiomyopathy, The Journal of Clinical Investigation (2001, 107: 967-974). PMID: 11306600

Freeman K, Colon-Rivera C, Olsson MC, Moore RL, Weinberger HD, Grupp IL, Vikstrom K, Iaccarino G, Koch WJ, and Leinwand LA.   Progression from hypertrophic to dilated cardiomyopathy in mice that express a mutant myosin transgene, The American Journal of Physiology (2001, 280: H151-H159). PMID: 11123229

Freeman K, Nakao K, Leinwand LA. Low sequence variation in the human cardiac b-myosin heavy chain gene, Genomics (2001, 76: 73-80). PMID: 11549319

Lerman I, Harrison B, Freeman K, Hewett TE, Allen DL, Robbins J, Leinwand LA.  Genetic variability in forced and voluntary endurance exercise performance in seven inbred mouse strains, The Journal of Applied Physiology (2002, 92: 2245-2255). PMID: 12015333

Freeman K, Farrow S, Schmaier A, Freedman R, Schork T, and Lockette W. Genetic polymorphism of the a2 -adrenergic receptor is associated with increased platelet aggregation, baroreceptor sensitivity, and salt excretion in normotensive humans, The American Journal of Hypertension (1995, 8:863-869). PMID: 8541000


James E. Demeules Surgical Research Award, University of Vermont (2009, 2010)

Tram L Tran (undergraduate) - Woodworth Prize and Honors College Award for physiology research in laboratory (2011)

Ali Sadeghi (undergraduate)- Honors College Award for MRI research (2011)

Last modified March 07 2016 01:14 PM