University of Vermont

College of Medicine

Freeman Laboratory - Department of Surgery


Emergency Medicine Research


Emergency Medicine Research includes the Research Associate Program, which provides the infrastructure to recruit patients from the Emergency Department for ongoing research projects. All of these projects are ultimately aimed at improving patient care.

Emergency Medicine Research projects were initiated by collaborating investigators, including medical students, UVM and The University of Vermont Medical Center faculty and staff, with sponsorship by a variety of sources, including the College of Medicine, the National Institutes of Health, the Department of Defense, and a biomedical equipment company. Student Research Associates are currently screening The University of Vermont Medical Center Emergency Department patients for several different IRB-approved studies, including the following:

Current Protocols:

1. Activation of Coagulation and Inflammation after Trauma (ACIT)
• Research Question: Can a comprehensive "natural history" of coagulation be constructed that can be used to predict which patients will develop a coagulopathy after traumatic injury?
• Principal Investigators: Kathleen Brummel-Ziedins, Ph.D. and Ken Mann, Ph.D., Department of Biochemistry

2. Oxidation-Reduction Potential as a Diagnostic Biomarker in Trauma and Sepsis
• Research Questions:
• Do oxidative-reduction potentials (ORPs) distinguish TBI patients from non- head injured controls?
• Do elevated ORP levels in head injury patients predict severe injury?
• Do elevated ORP levels correlate with post-concussive symptoms in patients with mild TBI?
• Principal Investigator: Kalev Freeman, MD, PhD, Department of Surgery

3. Post-Arrest Therapeutic Hypothermia with a Cooling Collar (PATH-C)
• Research Question: What is the effectiveness of the Excel Cryo Cooling Collar for inducing therapeutic hypothermia (TH) in the EMS setting?
• Principal Investigator: Dan Wolfson, MD, Department of Surgery

4. Temperature Evaluation by MRI-Thermometry with PRF during Cervical Cooling (TEM-C)
• Research Question: Investigate the MRI thermometry rate-of-cooling of the brain in subjects wearing the Excel Cryo Cooling Collar.
• Principal Investigator: Dan Wolfson, MD, Department of Surgery

5. Urine studies (sodium, potassium, creatinine and osmolality) as an early predictor of loop diuretic response for acute decompensated congestive heart failure with fluid overload.
• Research Question: Can urine studies obtained at 0, 2, and 6 hours post loop diuretic dose predict diuretic efficacy as measured by conventional methods (UOP, weight change, PE)?
• Principal Investigator: Richard Solomon, MD, Department of Medicine

6. Mobile Assessment After Trauma-Pilot (MAAT-P)
• Research Question: Evaluate the variation in mental health symptoms that occur in trauma victims post-discharge.
• Principal Investigator: Matthew Price, Ph.D., Department of Psychology

7. Biomarkers in Uncontrolled Asthma- Poorly Controlled Asthma Component
• Research Question: How do asthma medications (specficially Advair, Symbicort, and Dulera) affect asthma symptoms and what effects do these medications have on circulating factors in one's blood and nasal epithelial tissue?
• Principal Investigator: Anne Dixon, M.A., B.M., B.Ch., Pulmonary Disease and Critical Care Medicine

Past Protocols:

  1. Smoking Cessation #12-107 Tobacco Cessation Intervention Among Emergency Department Patients
  2. Stroke Education #11-207 Does Prehospital Stroke Education Improve Care Experience?
  3. NIMED #11-131 Nasogastric Insertion using Midazolam in the Emergency Department
  4. HITOP #11-111 Head Injury Testing and Outreach Program
  5. CBT #10-182 Cognitive Behavioral Therapy for Chronic Pain
  6. CETI #09-227 CT Exams for Traumatic Injuries
  7. Pronto-7 #12-288 Accuracy of Masimo Pronto 7 SpHb in the Emergency Department
  8. eFAST # 11-150 Extended Focused Assessment with Sonography for Trauma
  9. COMET #11-148 Carbon Monoxide Measurement and Emergency Treatment

Detailed information about current protocols can be found in the EMRAP Research Manual Fall 2015 (PDF)


UVM Surgery Dept. logo DOD logo Masimo logo NIH logo

Last modified November 11 2015 10:39 AM