University of Vermont

College of Medicine

Cardiovascular Research Institute of Vermont

Facilitating inter-departmental collaborations and the access to funding necessary to continue and enhance our tradition of excellence in cardiovascular research.

Cardiovascular Research Institute


A Mission to Foster Cardiovascular Research

The Cardiovascular Research Institute of Vermont (CVRI-VT) exists to foster cardiovascular research at The University of Vermont.  As an organization, it is broadly inclusive of investigators at the University of Vermont who are pursuing cardiovascular research and includes and serves members of multiple departments.  Our key objectives are to: 

  • improve communication, particularly across disciplines, departments, and colleges;
  • increase collaboration;
  • increase funding to support cardiovascular research; and
  • advance and highlight excellence in research nationally and internationally. 


CVRI Annual Report - Click here to view the CVRI Annual Report for 2014. 



Program Announcements 

2014-2015 Norman Alpert Visiting Professor 

Leslie A. Leinwand, PhD, the 2014-2015 Alpert Visiting Professor, will be on campus May 3-5 to meet individually and in small groups with investigators, trainees, and junior investigators.  She will also be providing two events open to all:

  • a noon research seminar titled "Translating Python Biology to Mammalian Hearts: Lessons in Cardiac Hypertrophy" on Monday, May 4th, in Davis Auditorium and

  • an "Early Career Investigators Forum" at 9:00 a.m. on Tuesday, May 5th in HSRF 200.

Dr. Leinwand is the HHMI Professor in the Department of Molecular, Cellular and Developmental Biology and the Chief Scientific Officer of the BioFrontiers Institute at the University of Colorado in Boulder, Colorado. 

Journal Club

In conjunction with Dr. Leinwand's visit and the May 8th visit by Dr. Marvin Konstam, Chief Physician Executive at Tufts University Medical Center, CVRI's Early Career Advisory Committee has planned a journal club on April 29th, Noon to 1:00 in Med Ed 300.  For pdfs of the articles to be discussed, click here:   Leinwand Article     Konstam Article



Cushman Lab

Dr. Cushman's research is in the study of biomarkers (phenotypes and genotypes) of various domains in relation to the risk of vascular diseases and other diseases of aging.  Working on population-based multicenter epidemiologic studies, she focuses on plaque stability, inflammation, blood coagulation, and fibrinolysis with a goal of generating hypotheses for basic bench research to address the pathophysiology of vascular diseases or clinical research to address preventive treatments.  Key areas of study include identification of reasons for racial disparities in stroke and cognitive impairment and epidemiology of venous thromboembolism.

Visit the Laboratory for Clinical Biochemistry Research to learn more.


Nelson Lab

Research in the Nelson lab is focused in 3 main areas:  understanding the control of smooth muscle and endothelial cell function by ion channel and calcium signaling; understanding “vascular crosstalk”—how sympathetic nerves, smooth muscle, and endothelial cells communicate to control the function of resistance-sized peripheral arteries; and understanding the basic mechanisms for ion channel control of vascular function to gain insight into pathologies and possible new therapeutic interventions.  Research approaches include molecular, cellular, intact tissue, whole organ, and in vivo (local CBF, blood pressure, and urodynamics) .

Click here to learn more about the work being done in Dr. Nelson’s lab. 


Cipolla Lab

The Cipolla laboratory studies the cerebral circulation under normal physiologic and pathologic conditions.  Of particular interest is how changes in cerebrovascular structure and function affect cerebral blood flow regulation and hemodynamics in ways that could promote brain injury.  In addition, we explore blood-brain barrier properties and how changes in permeability to water or solutes can cause injury, including seizure and white matter lesions.  Specific areas of interest include acute ischemic stroke and reperfusion injury, mechanisms and treatment of small vessel disease, and cerebrovascular adaptation to pregnancy as it relates to preeclampsia and eclampsia. 

Click here for the Cipolla lab's webpage.


Last modified April 28 2015 10:22 AM