University of Vermont

College of Medicine

Cardiovascular Research Institute of Vermont

Facilitating inter-departmental collaborations and the access to funding necessary to continue and enhance our tradition of excellence in cardiovascular research.

Cardiovascular Research Institute

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A Mission to Foster Cardiovascular Research

The Cardiovascular Research Institute of Vermont (CVRI-VT) exists to foster cardiovascular research at The University of Vermont.  As an organization, it is broadly inclusive of investigators at the University of Vermont who are pursuing cardiovascular research and includes and serves members of multiple departments.  Our key objectives are to: 

  • improve communication, particularly across disciplines, departments, and colleges;

  • increase collaboration;

  • increase funding to support cardiovascular research; and

  • advance and highlight excellence in research nationally and internationally. 



Lawrence Appel, MD, MPH, FAHC, FACP will be on campus February 5th as a CVRI Visiting Professor. Dr. Appel is the Molina Professor of Medicine, Epidemiology, Nursing, and International Health at Johns Hopkins School of Medicine; he is also Director of the Welch Center for Prevention, Epidemiology and Clinical Research at Johns Hopkins and Chair of the AHA Council on Lifestyle and Cardiometabolic Health.  Dr. Appel is an expert in design and interpretation of research; he has also continuously mentored students, fellows, and junior faculty.  His numerous awards and honors include recognition for being in the top 4th percentile in NIH funding and for excellence in mentoring; he has also received multiple awards for best published research paper of the year. Click here for Dr. Appel's bio.

       While at UVM, Dr. Appel will be in small-group meetings with junior- and mid-career investigators, and the following events will be held: 

  • Journal club - Tuesday, February 2nd - Rowell 107 at noon - lunch will be provided - sponsored by CVRI's Early Career Advisory Committee:  Dr. Appel's publications on the POWER and the OmniCarb studies will be reviewed (click here for copies of the articles)
  • Medicine Grand Rounds - Translating Effective Lifestyle Interventions into Practice: Lessons from the Hopkins-Healthways Collaboration - Friday, February 5th - Davis Auditorium at 8:00 a.m. - breakfast will be provided beginning at 7:15 a.m.

Applications for Travel Awards are now being accepted - click here for information and the application form. 

CVRI provides internal review of grant applications to support cardiovascular research. E-mail CVRI for more information.  ***NOTE: The request for internal review must be made at least 6 weeks before the submission deadline. 


CVRI Annual Report - Through a summary of CVRI activities and a compilation of cardiovascular-related research, patent, and publication highlights, the CVRI Annual Report demonstrates the depth and breadth of the cardiovascular research being conducted at the University of Vermont and the UVM Medical Center. Click here to view the CVRI Annual Report for 2014. 



Cushman Lab

Dr. Cushman's research is in the study of biomarkers (phenotypes and genotypes) of various domains in relation to the risk of vascular diseases and other diseases of aging.  Working on population-based multicenter epidemiologic studies, she focuses on plaque stability, inflammation, blood coagulation, and fibrinolysis with a goal of generating hypotheses for basic bench research to address the pathophysiology of vascular diseases or clinical research to address preventive treatments.  Key areas of study include identification of reasons for racial disparities in stroke and cognitive impairment and epidemiology of venous thromboembolism.

Visit the Laboratory for Clinical Biochemistry Research to learn more.


Nelson Lab

Research in the Nelson lab is focused in 3 main areas:  understanding the control of smooth muscle and endothelial cell function by ion channel and calcium signaling; understanding “vascular crosstalk”—how sympathetic nerves, smooth muscle, and endothelial cells communicate to control the function of resistance-sized peripheral arteries; and understanding the basic mechanisms for ion channel control of vascular function to gain insight into pathologies and possible new therapeutic interventions.  Research approaches include molecular, cellular, intact tissue, whole organ, and in vivo (local CBF, blood pressure, and urodynamics) .

Click here to learn more about the work being done in Dr. Nelson’s lab. 


Cipolla Lab

The Cipolla laboratory studies the cerebral circulation under normal physiologic and pathologic conditions.  Of particular interest is how changes in cerebrovascular structure and function affect cerebral blood flow regulation and hemodynamics in ways that could promote brain injury.  In addition, we explore blood-brain barrier properties and how changes in permeability to water or solutes can cause injury, including seizure and white matter lesions.  Specific areas of interest include acute ischemic stroke and reperfusion injury, mechanisms and treatment of small vessel disease, and cerebrovascular adaptation to pregnancy as it relates to preeclampsia and eclampsia. 

Click here for the Cipolla lab's webpage.


Last modified March 02 2016 11:21 AM