University of Vermont

College of Medicine

Clinical Neuroscience Research Unit


Estrogen, Menopause, and the Brain Research


The overarching goal of this program is to conduct clinical research studies that seek to understand the mechanisms behind changes in cognition and behavior that occur in women after menopause. Menopause produces significant and sustained changes in the levels of sex hormones (e.g. estrogen) that have profound effects on brain functioning and may produce changes in mood, memory, and learning. These changes may account for gender-related differences between older women and men, especially regarding rates of neurodegenerative disorders, some of which tend to be higher in women (e.g. Alzheimer's disease).


The studies utilized intensive, repeated-measures designs focusing on the effects of neuropharmacologic probes combined with sophisticated cognitive testing, functional brain imaging, and behavioral paradigms in older women. Most of the studies take place at the University of Vermont Clinical Research Center (CRC).

Contact Julie Dumas, Ph.D., (802) 847-2523 for more information.

Last modified August 26 2016 02:02 PM