Dr. Butenas received his Ph.D. In Organic Chemistry from the Kaunas University of Technology, Lithuania in 1985. His postdoctoral work at the Institute of Biochemistry, Vilnius, Lithuania focused on developing and synthesizing substrates for serine proteases. His work resulted in the development of a new class of ultrasensitive fluorogenic substrates and methods based on them for the quantitation of serine proteses involved in blood coagulation and fibrinolysis. He joined the Biochemistry Department in 1991 as part of the group led by Dr. Kenneth G. Mann, which investigates processes of blood coagulation and its regulation.
Butenas, S., van't Veer, C., Mann, K.G. (1997). Evaluation of the initiation phase of blood coagulation using ultrasensitive assays for serine proteases. J. Biol. Chem., 272:21527-21533.
Butenas, S., van't Veer, C., Mann, K.G. (1999). "Normal" thrombin generation. Blood, 94:2169-2178.
All Butenas Publications
Butenas, S., Cawthern, K.M., van't Veer, C., DiLorenzo, M., Lock, J.B., Mann, K.G. (2001). Antiplatelet agents in tissue factor-induced blood coagulation. Blood, 97:2314-2322.
Butenas, S., Brummel, K.E., Branda, R.F., Paradis, S.G., Mann, K.G. (2002). Mechanism of factor VIIa-dependent coagulation in Hemophilia blood. Blood, 99:923-930.
Butenas, S., Dee, J.D., Mann, K.G. (2003). The function of factor XI in tissue factor-initiated thrombin generation. J. Thromb. Haemost., 1:2103-2111.
Butenas, S., Orfeo, T., Gissel, M.T., Brumel, K.E., Mann, K.G. (2004). The significance of circulating factor IXa in blood. J. Biol. Chem., 279:22875-22882.
Butenas, S, Bouchard, BA, Brummel-Ziedins, KE, Parhami-Seren, B, Mann, KG (2005). Tissue factor activity in whole blood. Blood, 105:2764-2770.
Butenas, S, Orfeo, T, Kalafatis, M, Mann, KG. Peptidomimetic inhibitors for activated protein C: implications for hemophilia management. J. Thromb. Haemost. 2006;4:2411-2416.
Butenas, S, Orfeo, T, Mann, KG. Tissue factor actiity and function in blood coagulation. Thromb. Res. 2008;122 (Suppl. 1):S42-S46 (Review).
Butenas, S, Parhami-Seren, B, Mann, KG. The influence of von Willebrand factor on factor VIII activity measurement. J. Thromb. Haemost. 2009;7:132-137.