University of Vermont

College of Medicine

Department of Biochemistry

Bio for Christopher Berger
Christopher Berger

Christopher Berger


Contact Information
E-mail: Christopher.Berger@uvm.edu
Office Location:
Moleculr Physolgy & Bioph, Given Building Room E217

Expertise

I received my Ph.D. in Biochemistry at the University of Minnesota in 1991, and did my post-doctoral research at the University of Pennsylvania. I have been on the faculty at the University of Vermont since 1994, with a primary appointment in Molecular Physiology & Biophysics and a secondary appointment in Biochemistry. I have been actively involved in the CMB Program, serving as the Program’s Director from 2003-2006, and am currently the Director of Graduate Education for the College of Medicine.

Awards and Honors

National Institutes of Health MSFC Study Section Member

Biophysical Society Council

Biophysical Journal Editorial Board

Ad-Hoc Member, National Institutes of Health BBCB Study Section 2001-2004

University of Vermont College of Medicine Faculty Development Award

Muscular Dystrophy Association Post-Doctoral Fellowship

University of Minnesota Doctoral Dissertation Award

Publications

Robertson, C.I., Gaffney, D.P., Chrin, L.R., and Berger, C.L. Structural Rearrangements in the Active Site of Smooth-Muscle Myosin. Biophys J. 2005 Sep;89(3):1882-92

Robertson, C.I., Gaffney, D.P., Chrin, L.R., and Berger, C.L. (2005). Structural Rearrangements in the Active Site of Smooth-Muscle Myosin. Biophys J., 89(3):1882-92

van Duffelen, M., Chrin, L.R., and Berger, C.L. Kinetics of structural changes in the relay loop and SH3 domain of myosin. Biochem Biophys Res Commun. 2005 Apr 8;329(2): 563-72

van Duffelen, M., Chrin, L.R. and Berger, C.L. Nucleotide dependent intrinsic fluorescence changes of W29 and W36 in smooth muscle myosin. Biophys J 2004 87(3):1767-1775

Yengo, C.M., Chrin, L.R., Rovner, A.S. and Berger, C.L. Tryptophan 512 is sensitive to conformational changes in the rigid relay loop of smooth muscle myosin during the MgATPase cycle. J Biol Chem. 2000 Aug 18;275(33):25481-7


All Berger Publications

Yengo, C.M., De La Cruz, E.M., Chrin, L.R., Gaffney, D.P. and Berger, C.L. (2005). Actin-induced closure of the actin-binding cleft of smooth muscle myosin. J Biol Chem., 277(27):24114-9

van Duffelen, M., Chrin, L.R., and Berger, C.L. (2005). Kinetics of structural changes in the relay loop and SH3 domain of myosin. Biochem Biophys Res Commun., 329(2): 563-72

van Duffelen, M., Chrin, L.R. and Berger, C.L. (2004). Nucleotide dependent intrinsic fluorescence changes of W29 and W36 in smooth muscle myosin. Biophys J, 87(3):1767-1775

Yengo, C.M., Chrin, L.R., Rovner, A.S. and Berger, C.L. (2000). Tryptophan 512 is sensitive to conformational changes in the rigid relay loop of smooth muscle myosin during the MgATPase cycle. J Biol Chem., 275(33):25481-7

Berger CL (2013) Breaking the millisecond barrier: single molecule motors wobble to find their next binding sites. Biophys J 104(6): 1219-20. (link:http://www.ncbi.nlm.nih.gov/pubmed/23528080)

McVicker DP, Chrin LR, Berger CL (2011) The nucleotide-binding state of microtubules modulates kinesin processivity and the ability of Tau to inhibit kinesin-mediated transport. J Biol Chem 286(50): 42873-80. (link: http://www.ncbi.nlm.nih.gov/pubmed/22039058)

Lin WM, Lewis JM, Filler RB, Modi BG, Carlson KR, Reddy S, Thornberg A, Saksena G, Umlauf S, Oberholzer PA, Karpova M, Getz G, Mane S, Garraway LA, Dummer R, Berger CL, Edelson RL, Girardi M (2012) Characterization of the DNA copy-number genome in the blood of cutaneous T-cell lymphoma patients. J Invest Dermatol 132(1): 188-97. (link: http://www.ncbi.nlm.nih.gov/pubmed/21881587)

Decarreau JA, Chrin LR, Berger CL (2011) Loop 1 dynamics in smooth muscle myosin: isoform specific differences modulate ADP release. J Muscle Res Cell Motil 32(1): 49-61. (link: http://www.ncbi.nlm.nih.gov/pubmed/21643973)

Decarreau JA, James NG, Chrin LR, Berger CL (2011) Switch I closure simultaneously promotes strong binding to actin and ADP in smooth muscle myosin. J Biol Chem 286(25): 22300-7. (link: http://www.ncbi.nlm.nih.gov/pubmed/21536675)

Purcell TJ, Naber N, Franks-Skiba K, Dunn AR, Eldred CC, Berger CL, Málnási-Csizmadia A, Spudich JA, Swank DM, Pate E, Cooke R (2011) Nucleotide pocket thermodynamics measured by EPR reveal how energy partitioning relates myosin speed to efficiency. J Mol Biol 407(1): 79-91. (link: http://www.ncbi.nlm.nih.gov/pubmed/21185304)

Yengo CM, Berger CL (2010) Fluorescence anisotropy and resonance energy transfer: powerful tools for measuring real time protein dynamics in a physiological environment. Curr Opin Pharmacol 10(6): 731-7.  (link: http://www.ncbi.nlm.nih.gov/pubmed/20971683)