University of Vermont

College of Medicine

Department of Biochemistry

Bio for Jay R. Silveira
Jay R. Silveira

Jay R. Silveira


Contact Information
E-mail: Jay.Silveira@uvm.edu
Office Location:
Biochemistry, Given C413

Expertise

Dr. Silveira received his Ph.D. in 2001 from the Department of Biochemistry at the University of Vermont.  His graduate work with Dr. Paula Tracy involved assessing the effects of post-translational modifications on the function of factor V, a critical component of the coagulation cascade.  After completing his graduate work, Dr. Silveira obtained a postdoctoral fellowship and worked with Dr. Byron Caughey’s prion research group at the National Institutes of Health’s Rocky Mountain Laboratory facility in Hamilton, Montana.  Dr. Silveira’s research on prions established a relationship between prion infectivity and the size of prion protein aggregates, revealing that smaller aggregates are inherently more infectious than larger ones.  In 2006, Dr. Silveira returned to Vermont and joined the faculty of the Biochemistry department where he serves as a lecturer and a member of Dr. Paula Tracy’s research group. In 2011 he was promoted to Assistant Professor.

Publications

DeMarco, M.L., Silveira, J.R., Caughey, B., Daggett, V.  Structural properties of prion protein protofibrils and fibrils:  An experimental assessment of atomic models.  Biochemistry 45:15573-15582, 2006.


Silveira J.R., Raymond G.J., Hughson A.G., Race R.E., Sim V.L., Hayes S.F., Caughey B.  The most infectious prion protein particles.  Nature 437:257-261, 2005.


Gould W.R., Simioni P., Silveira J.R., Tormene D., Kalafatis M., Tracy P.B.  Megakaryocytes endocytose and subsequently modify human factor V in vivo to form the entire pool of a unique platelet-derived cofactor.  Journal of Thrombosis and Haemostasis 3(3):450-456, 2005.


Silveira, J.R., Gould, W.R., Tracy, P.B.  Unique in vivo modifications of coagulation factor V produce a physically and functionally distinct platelet-derived cofactor: Characterization of purified platelet-derived factor V/Va.  Journal of Biological Chemistry 279(4):2383-2393, 2003.


Silveira, J.R., Kalafatis, M., Tracy, P.B.  Carbohydrate moieties on the procofactor factor V, but not the derived cofactor factor Va, regulate its inactivation by activated protein C.  Biochemistry 41(5):1672-1680, 2002.


All Silveira Publications
Wood JP, Silveira JR, Maille NM, Haynes LM, Tracy PB (2011) Prothrombin activation on the activated platelet surface optimizes expression of procoagulant activity. Blood 117(5): 1710-8.

Regis L, Souza WV, Furtado AF, Fonseca CD, Silveira Jr JC, Ribeiro Jr PJ, Melo-Santos MA, Carvalho MS, Monteiro AM (2009) An entomological surveillance system based on open spatial information for participative dengue control. An Acad Bras Cienc 81(4): 655-62.

Silveira JR, Hughson AG, Caughey B (2006) Fractionation of prion protein aggregates by asymmetrical flow field-flow fractionation. Methods Enzymol 412: 21-33.

Caughey B, Caughey WS, Kocisko DA, Lee KS, Silveira JR, Morrey JD (2006) Prions and transmissible spongiform encephalopathy (TSE) chemotherapeutics: A common mechanism for anti-TSE compounds? Acc Chem Res 39(9): 646-53.

Sánchez RM, Sierra AP, Obregón Fuentes AM, González IR, Gil AB, Suárez MB, Silveira JR, Gastón BD (2002) [Reactogenecity and immunogenecity of Cuban trivalent inactivated vaccine against human leptospirosis in different vaccination schedules]. Rev Cubana Med Trop 54(1): 37-43.

Wood, J., Silveira, J., Maille, N., Haynes, L., and Tracy, P. Prothrombin activation on the activated platelet surface optimizes expression of procoagulant activity. Blood. 2011 Feb 3;117(5):1710-8.

Gould, W., Simioni, P., Silveira, J., Tormene, D., Kalafatis, M., and Tracy, P. Megakaryocytes endocytose and subsequently modify human factor V in vivo to form the entire pool of a unique platelet-derived cofactor. Journal of Thrombosis and Haemostasis 3(3):450-456, 2005.

Silveira J., Raymond G., Hughson A., Race R., Sim V., Hayes S., and Caughey B. The most infectious prion protein particles. Nature 437:257-261, 2005.