University of Vermont

College of Medicine

Department of Biochemistry

Bio for Beth Bouchard
Beth Bouchard

Beth Bouchard


Contact Information
E-mail: Beth.Bouchard@uvm.edu
Office Location:
Biochemistry, Given C440A

Research Interests

The overall focus of the research performed in my laboratory is to define the cellular and molecular mechanisms that regulate assembly and function of the enzyme complexes involved in blood coagulation on blood cells in normal and disease processes.  We are using a variety of biochemical and cell biological techniques to define these mechanisms. 

Expertise

I received my Ph.D. in the Cell & Molecular Biology Program at the University of Vermont. My dissertation research focused on the regulation of procoagulant enzyme complex assembly and function on cells. During a Postdoctoral Fellowship with Barbara Furie, Ph.D. at Harvard Medical School, I continued with my research interests in coagulation studying the vitamin K-dependent gamma-glutamyl carboxylase, the enzyme responsible for catalyzing an important post-translational modification of the blood clotting proteins. I subsequently returned to UVM and am currently an Assistant Professor of Biochemistry.

Publications

Bouchard BA, Chapin J, Brummel-Ziedins KE, Durda P, Key NS and Tracy PB:  Platelets and platelet-derived factor Va confer hemostatic competence in total factor V deficiency. Blood 125(23):3647-3650, 2015.

http://www.bloodjournal.org/content/bloodjournal/125/23/3647.full.pdf

 

Gertz JM and Bouchard BA:  Mechanisms Regulating Acquisition of Platelet-Derived Factor V/Va by Megakaryocytes (Prospect). J. Cell. Bioch. doi: 10.1002/jcb.25163. [Epub ahead of print].

 

Bouchard BA, Silveira JR and Tracy PB:  Interactions between platelets and the coagulation system. In:  Platelets (Third Edition), Michelson AD (Ed), Academic Press, San Diego, CA, pp. 425-451, 2013.

 

Ayombil F, Abdalla S, Tracy PB and Bouchard BA:  Proteolysis of plasma-derived factor V following its endocytosis by megakaryocytes forms the platelet-derived factor V/Va pool.  J. Thromb. Haemosta. 11(8):1532-1539, 2013. 

http://onlinelibrary.wiley.com/doi/10.1111/jth.12307/epdf

 

Bouchard BA, Abdalla S, and Tracy PB:  The factor V light chain mediates the binding and endocytosis of plasma-derived factor V by megakaryocytes. J. Thromb. Haemosta. 11(12):2181-2183, 2013.

http://onlinelibrary.wiley.com/doi/10.1111/jth.12417/epdf

 

Bouchard BA, Paradis AK and Brummel-Ziedins KE:  Measurement of procoagulant platelet subpopulations in whole blood:  Development of an assay for population-based studies (Letter to the Editor).  Thromb. Res. 127:62-64, 2011.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2955998/pdf/nihms208921.pdf

 

Bouchard BA, Meisler NT, Nesheim ME, Liu C-X, Strickland DK, and Tracy PB:  A unique function for LRP-1: A component of a two-receptor system mediating specific endocytosis of plasma-derived factor V by megakaryocytes. J. Thromb. Haemost. 6:638-644, 2008.

http://onlinelibrary.wiley.com/doi/10.1111/j.1538-7836.2008.02894.x/epdf

 

Bouchard BA, Williams JL, Meisler NT, Long MW and Tracy PB:  Endocytosis of plasma factor V by megakaryocytes occurs via a clathrin-dependent, specific receptor-mediated event. J. Thromb. Haemost. 3:541-551, 2005.

http://onlinelibrary.wiley.com/doi/10.1111/j.1538-7836.2005.01190.x/epdf

 


Other Interest

7/13-present    Member, American Heart Association, Vermont Affiliate, Community Action Committee (CAC)

7/13-present    Member, American Heart Association, Vermont Affiliate, HeartWalk Leadership Team/Executive Committee

1/15 – present  Team Captain, American Heart Association Vermont Heart Walk