University of Vermont

College of Medicine

Department of Biochemistry

Bio for Beth Bouchard
Beth Bouchard

Beth Bouchard


Contact Information
E-mail: Beth.Bouchard@uvm.edu
Office Location:
Biochemistry, Given C440A

Research Interests

Both I and my student Jacquie attended the 2014 GRC on Hemostasis last summer. She presented the following abstract as a poster presentation:

Gertz JG and Bouchard BA: 
Characterization of factor V endocytosis as a function of human megakaryocyte differentiation and proplatelet formation in the umbilical cord blood model. Gordon Research Conference on Hemostasis, Waterville Valley Resort, Waterville Valley, NH, July 27–August 1, 2014.

I was an invited speaker and gave the following talk:
“Processes defining megakaryocyte formation of the platelet-derived factor V/Va pool.” Gordon Research Conference on Hemostasis, Waterville Valley Resort, Waterville Valley, NH, July 27–August 1, 2014.

Expertise

I received my Ph.D. in the Cell & Molecular Biology Program at the University of Vermont. My dissertation research focused on the regulation of procoagulant enzyme complex assembly and function on cells. During a Postdoctoral Fellowship with Barbara Furie, Ph.D. at Harvard Medical School, I continued with my research interests in coagulation studying the vitamin K-dependent gamma-glutamyl carboxylase, the enzyme responsible for catalyzing an important post-translational modification of the blood clotting proteins. I subsequently returned to UVM and am currently an Assistant Professor of Biochemistry.

Publications

Sharma D, Brummel-Ziedins KE, Bouchard BA, and Holmes CE:  Platelets in Tumor Progression:  A Host Factor Offering Multiple Potential Targets in the Treatment of Cancer. J. Cell. Physiol. 229(8):1005-1015, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24374897

Bouchard BA, Abdalla S, and Tracy PB:  The factor V light chain mediates the binding and endocytosis of plasma-derived factor V by megakaryocytes. J. Thromb. Haemosta. 2013 Sep 30. doi: 10.1111/jth.12417.

Ayombil F, Abdalla S, Tracy PB and Bouchard BA:  Proteolysis of plasma-derived factor V following its endocytosis by megakaryocytes forms the platelet-derived factor V/Va pool.  J. Thromb. Haemosta. 11(8):1532-1539, 2013.

Bouchard BA, Silveira JR and Tracy PB:  Interactions between platelets and the coagulation system. In:  Platelets (Third Edition), Michelson AD (Ed), Academic Press, San Diego, CA, pp. 425-451, 2013.

Bouchard BA, Paradis AK and Brummel-Ziedins KE:  Measurement of procoagulant platelet subpopulations in whole blood:  Development of an assay for population-based studies.  Thromb. Res. 127:62-64, 2011. http://www.ncbi.nlm.nih.gov/pubmed/20541793

Bouchard, B.A., Meisler, N.T., Nesheim, M.E., Liu, C.X., Strickland, D.K., and Tracy, P.B. A unique function for LRP-1: a component of a two-receptor system mediating specific endocytosis of plasma-derived factor V by megakaryocytes. J Thromb Haemosta 6(4):638-44, 2008. Link

Bouchard, B.A., Williams, J.L., Meisler, N.T., Long, M.W. and Tracy, P.B. Endocytosis of plasma factor V by megakaryocytes occurs via a clathrin-dependent, specific receptor-mediated event. J Thromb Haemosta 3:541-551, 2005 Link

Other Interest

7/13-present     Member, American Heart Association, Vermont Affiliate, Community Action Committee (CAC)

7/13-present     Member, American Heart Association, Vermont Affiliate, HeartWalk Leadership Team/Executive Committee

1/15 – present  Team Captain, American Heart Association Vermont Heart Walk