University of Vermont

College of Medicine

Department of Biochemistry

Bio for Kenneth Mann, Ph.D.
Kenneth Mann, Ph.D.

Kenneth Mann, Ph.D.


Contact Information
E-mail: Kenneth.Mann@uvm.edu
Office Location:
Biochemistry, Colch Res Fac 235C

Expertise

Dr. Mann received his Ph.D. in Biochemistry (C.S. Vestling) at the University of Iowa. After additional post- doctoral training in physical biochemistry at Duke University (C. Tanford), he moved to the University of Minnesota as an Assistant Professor. His interest in applying Physical Biochemistry techniques to elucidating the varied physical and functional interactions of proteins in the blood coagulation process led to a move to the Mayo Clinic (Mayo Medical School), where he achieved the rank of Professor of Biochemistry and Medicine and became Vice Chair of the Department of Medicine. He came to UVM in 1984 as Professor and Chair of Biochemistry and he relinquished the Chair in 2005. He became an active emeritus professor in 2013 and maintains a large extramurally funded research program in Colchester. Dr. Mann has received many National and international awards, including the E. Donnall Thomas Award (ASH), the Sherry Award (AHA), the Wood Medal (ISTH), the Pioneer in Hematology Award (ASH), the Distinguished Alumnus Award (Mayo Foundation), the Distinguished Alumnus Achievement Award (University of Iowa), the Henri Chaigneau Prize (Association Francaise des Hemophiles), received a Special Recognition Award from the American Heart Association in 2008 and was named a Distinguished Scientist by the American Heart Association in 2011.

Publications

Undas A, Brummel-Ziedins KE and Mann KG. (2007). Antithrombotic properties of aspirin and resistance to aspirin: beyond strictly antiplatelet actions. Blood. 109(6):2285-92.

Butenas S, Gissel M, Krudysz-Amblo J, Mann KG (2013) The nature of lipopolysaccharide-stimulated monocyte tissue factor activity. Blood Coagul Fibrinolysis.

Krudysz-Amblo J, Jennings ME 2nd, Knight T, Matthews DE, Mann KG, Butenas S (2013) Disulfide reduction abolishes tissue factor cofactor function. Biochim Biophys Acta 1830(6): 3489-96.

Whelihan MF, Mann KG (2013) The role of the red cell membrane in thrombin generation. Thromb Res 131(5): 377-82.

Foley JH, Orfeo T, Undas A, McLean KC, Bernstein IM, Rivard GE, Mann KG, Everse SJ, Brummel-Ziedins KE (2013) From principle to practice: bridging the gap in patient profiling. PLoS One 8(1): e54728.

Haynes LM, Dubief YC and Mann KG. Membrane binding events in the initiation and propagation phases of tissue factor initiated zymogen activation under flow. J. Biol. Chem. 287:5225-34, 2012. PMID: 22187432.

Bravo MC, Orfeo T, Mann KGand Everse SJ. Modeling of human factor Va inactivation by activated protein C. BMC Syst Biol. 6:45, 2012. PMID: 22607732

Mann KG. Is there value in kinetic modeling? Yes. J Thromb Haemost. 10:1463-1469, 2012.  PMID: 22642417

Whelihan MF, Zachary V, Orfeo T and Mann KG. Prothrombin activation in blood coagulation: the erythrocyte contribution to thrombin generation. Blood. 120:3837-3845, 2012. PMID: 22968460. PMCID: PMC3488

Haynes LM, Orfeo T, Mann KG (2012) Rivaroxaban delivery and reversal at a venous flow rate. Arterioscler Thromb Vasc Biol 32(12): 2877-83.

Fuster V, Bhatt DL, Califf RM, Michelson AD, Sabatine MS, Angiolillo DJ, Bates ER, Cohen DJ, Coller BS, Furie B, Hulot JS, Mann KG, Mega JL, Musunuru K, O’Donnell CJ, Price MJ, Schneider DJ, Simon DI, Weitz JI, Williams MS, Hoots WK, Rosenberg YD, Hasan AA (2012) Guided antithrombotic therapy: current status and future research direction: report on a National Heart, Lung and Blood Institute working group. Circulation 126(13): 1645-62.

Haynes LM, Bouchard BA, Tracy PB, Mann KG (2012) Prothrombin activation by platelet-associated prothrombinase proceeds through the prethrombin-2 pathway via a concerted mechanism. J Biol Chem 287(46): 38647-55.


Mann, KG. Thrombin generation in hemorrhage control and vascular occlusion. Circulation. 124:225-35, 2011. PMID: 21747067