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        Genetics, epigenetics, and enviroment are involved in the etiologies of complex
human diseases. Our research aims to identify factors that predispose an individual to genetic disease, particularly mental illness, using a combined genetic, epigenetic, and brain imaging approach. We use the latest high-throughput experimental and computational tools with an emphasis on analytic aspects in our patient cohorts. Our research may advance the development of disease prevention and treatment.

      Current Research Topics

A.     Genome-wide meta-analysis of SNP and CNV association study:  The following figure shows the overall design of one of our recent studies. In this example, we have recruited large patient cohorts, and recently completed genome-wide genotyping experiments. The next step is to leverage the big data to identify disease-associated genes using advanced computational tools.

project_design

B.      Exome sequencing

C.      DNA methylation

D.      
Brain imaging
brain

E.      Study the complexity of childhood behaviors using combined genetics, epigenetics, and imaging approaches

ANN