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Our past research focused on genetic association studies of identifying structural variations and single-point mutations in various brain disorders. Our recent research includes two directions. One is family-based genetic analysis of rare diseases. The other is to identify viral DNA in the human genome. We developed a comprehensive platform to better capture viruses and viral integrations in the human samples, particularly tumor tissues. Findings from our research may inform the development of disease prevention, diagnosis, and treatment strategies.

Direction I - Genetic analyses to identify putative causal mutations using whole-exome sequencing

        This part of research aims to identify potential causal genes in families with rare or rare forms of disease using next-generation sequencing and advanced statistical and computational analyses. Findings from the research will provide better understanding of the disease mechanisms.

   (an example of our research families of symptomatic Chiari I malformation)

        Our team is actively recuiting new families to participant in our genetic analysis.

Direction II - Viral etiologies in various human diseases using -omics approaches

        Many human diseases are speculated to have viral etiologies, including brain diseases. Next-generation sequencing (NGS) allows us to capture viral sequences in human samples. We have developed a virome-wide approach in our laboratory to identify viruses and viral integrations. We have applied this approach to various patient samples and identified disease-associated viral integrations. Our data demonstrated that our platform has very high accuracy and sensitivity.