Dr. Seth Frietze performed his postdoctoral training at the University of Southern California and has served as an assistant professor at the School of Biological Sciences at the University of Northern Colorado prior to joining the faculty of the Department of Medical Laboratory and Radiation Science as an assistant professor in 2015. Dr. Frietze is invested in the next generation of scientists, and seeks to train his students to use cutting-edge molecular technologies and to apply basic research skills to address important biomedical questions.
Research and/or Creative Works
Whole-genome sequencing applications have created a revolution in the way we study disease and biology. A major challenge in training the next generation of scientists to utilize these rapidly evolving technologies is to provide them with the basic skills to analyze and to apply these approaches to address important biological questions. Research in the Frietze Laboratory applies these approaches to study the molecular mechanisms of gene regulation with the long-term goal of discovering new therapeutic strategies to target cancer cells.
The regulation of gene expression is fundamental to all biological processes and plays a central role in cancer. A major goal of the laboratory is to understand the interplay between chromatin structure and transcriptional regulators to guide distinct expression programs of disease. This work involves exploring chromatin structure genome-wide and understanding how aberrant changes in epigenetic modification can affect the expression of key genes and contribute to the pathological progression of cancer.
Fuller R, Frietze S, McGlaughlin M. "Characterization of 13 Microsatellite Markers for Calochortus gunnisonii (Liliaceae) from Illumina MiSeq Sequencing". Applications in Plant Sciences. 2015 Aug 14;3(8).
Gaddis M, Gerrard D, Frietze S and Farnham PJ. "Altering cancer transcriptomes using epigenomic inhibitors". Epigenetics and Chromatin. Epigenetics Chromatin. 2015Feb 24;8:9.
Dichosa AE, Davenport KW, Li PE, Ahmed SA, Daligault H, Gleasner CD, Kunde Y, McMurry K, Lo CC, Reitenga KG, Daughton AR, Shen X, Frietze S, Wang D, Johnson SL, Drautz-Moses DI, Schuster S, Chain PS, Han C. "Draft Genome Sequence of Thauera sp. Strain SWB20, Isolated from a Singapore Wastewater Treatment Facility Using Gel Microdroplets." Genome Announc. 2015 Mar 19;3(2).
Frietze S, O'Geen H, Littlepage LE, Simion C, Sweeney CA, Farnham PJ, Krig SR. "Global analysis of ZNF217 chromatin occupancy in the breast cancer cell genome reveals an association with ERalpha". BMC Genomics. 2014 Jun 24;15:520.
Schjerven H, McLaughlin J, Arenzana TL, Frietze S, Cheng D, Wadsworth SE, Lawson GW, Bensinger SJ, Farnham PJ, Witte ON, Smale ST. "Selective regulation of lymphopoiesis and leukemogenesis by individual zinc fingers of Ikaros." Nature Immunology. 2013 Oct;14(10):1073-83.
Gerstein M B, et al., Architecture of the human regulatory network derived from ENCODE data. Nature. 2012 Sep 6;489(7414):91-100.
Frietze S, Wang R, Tak Y, Ye Z, Farnham PJ and Jin VX, Cell type-specific patterns of TCF7L2 binding reveal an association with enhancers and co-localizing transcription factors. Genome Biol. 2012 Sep 5;13(9).
The ENCODE Project Consortium. An Integrated Encyclopedia of DNA Elements in the Human Genome. Nature. 2012 Sep 6;489(7414):57-74.
Krig S R, Frietze S, Simion C, Fry WH, Miller JK, Rafidi H, Kotelawala L, Carraway KL III and Sweeney C. Lrig1 contributes to estrogen-mediated repression of ErbB2 – a novel cross-talk between ER-alpha and ErbB2. Mol Cancer Res. 2011 Oct;9(10):1406-17.
Frietze S and Farnham PJ, Transcription factor effector domains. Subcell Biochem. 52:261-77, 2011.
A user's guide to the encyclopedia of DNA elements (ENCODE). ENCODE Project Consortium, Myers RM, et al. PLoS Biol. 2011 Apr;9(4), 2011.
Frietze S, O'Geen H, Jin VX, Farnham PJ. "ZNF274 recruits the histone methyltransferase SETDB1 to the 3' ends of zinc finger genes." PLOS One. Dec; 5(12) 2010.
O'Geen H, Frietze S, Farnham PJ. "Using ChIP-seq Technology to Identify Targets of Zinc Finger Transcription Factors." Engineered Zinc Finger Proteins, Methods in Molecular Biology 649, 2010.
Krig SR, Miller JK, Frietze S, Beckett LA, Neve RM, Farnham PJ., Yaswen PI, Sweeney CA. "ZNF217, a candidate breast cancer oncogene amplified at 20q13, regulates expression of the ErbB3 receptor tyrosine kinase in breast cancer cells." Oncogene. Oct 7;29(40):5500-10. 2010.
Frietze S, Meyer Lan X, Jin VX, Farnham PJ. "Genomic Targets of the KRAB and SCAN domain-containing Zinc Finger Protein ZNF263." Journal of Biological Chemistry. Jan 8;285(2):1393-403. 2010.
Areas of Expertise and/or Research
- Regulation of gene expression
- Chromatin structure and epigenetics
- Transcriptomics of vertebrate development and evolution
- Metagenomics and molecular diagnostics
- Postdoctoral training, University of Southern California Medical School, Norris Cancer Center, Los Angeles, CA
- Ph.D., Harvard Medical School, Harvard University, Cambridge, MA
- B.S., Biochemistry, B.A., Chemistry, New Mexico State University, Las Cruces, NM
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302A Rowell Building