Assistant Professor

Research in the Krementsov laboratory is focused on understanding the molecular mechanisms underlying the pathogenesis of immune-mediated or infectious diseases. One of our principal interests is the autoimmune disease multiple sclerosis (MS), the most common neurologic disorder affecting young adults, which occurs occurs when the immune system aberrantly initiates an attack against the central nervous system. MS is three times more prevalent in women, and our research is aimed at understanding why and how the disease affects women and men differently. This line of investigation has uncovered a druggable molecular pathway in myeloid cells (macrophages or microglia), which is regulated by sex hormones.

Additionally, we are studying the genetic basis of MS, and how these genes may interact with various environmental risk factors such as vitamin D deficiency, or imbalance in the gut microbiome. The latter is of particular interest, and we are investigating the complex dialogue between the genome of the mammalian host and the commensal bacteria residing in the gut.

Other interests in the lab include genetics of other immune-mediated diseases such as inflammatory bowel disease, as well as genetics of host-pathogen interactions, especially viruses. We employ various immunologic and molecular techniques, animal and cellular models, as well as genomic approaches, including transcriptomics, bioinformatic analysis, forward genetics, 16S sequencing, etc.

Publications

  • Raza A, Crothers JW, McGill MM, Mawe GM, Teuscher C, Krementsov DN. Anti-inflammatory roles of p38α MAPK in macrophages are context-dependent and require IL-10. J Leuk Biol. 2017 Accepted
  • Krementsov DN, Case LK, Dienz O, Raza A, Fang Q, Ather JL, Poynter ME, Boyson JE, Bunn JY, Teuscher C. Genetic variation in chromosome Y regulates susceptibility to influenza A virus infection.  Proc Natl Acad Sci U S A. 2017 Feb 27. pii: 201620889. PMID: 28242695
  • Bearoff F, del Rio R, Case LK, Dragon JA, Nguyen-Vu T, Lin CY, Blankenhorn EP, Teuscher C, Krementsov DN. Natural genetic variation profoundly regulates gene expression in immune cells and dictates susceptibility to CNS autoimmunity. Genes and Immunity 2016 Dec;17(7):386-395. doi:10.1038/gene.2016.37. PMID: 27653816
  • Krementsov DN, Case LK, Hickey WF, Teuscher C. Exacerbation of autoimmune neuroinflammation by dietary sodium is genetically controlled and sex specific. FASEB J. 2015 Aug;29(8):3446-57. PubMed PMID: 25917331
  • Krementsov DN, Noubade R, Dragon JA, Otsu K, Rincon M, Teuscher C. Sex-specific control of central nervous system autoimmunity by p38 mitogen-activated protein kinase signaling in myeloid cells. Ann Neurol. 2014 Jan;75(1):50-66. PubMed PMID: 24027119
  • Krementsov DN, Thornton TM, Teuscher C, Rincon M. The emerging role of p38 mitogen-activated protein kinase in multiple sclerosis and its models. Mol Cell Biol. 2013 Oct;33(19):3728-34. PubMed PMID: 23897428
  • Krementsov DN, Katchy A, Case LK, Carr FE, Davis B, Williams C, Teuscher C. Studies in experimental autoimmune encephalomyelitis do not support developmental bisphenol a exposure as an environmental factor in increasing multiple sclerosis risk. Toxicol Sci. 2013 Sep;135(1):91-102. PubMed PMID: 23798566
  • Krementsov DN, Teuscher C. Environmental factors acting during development to influence MS risk: insights from animal studies. Mult Scler. 2013 Nov;19(13):1684-9. PubMed PMID: 24077054

Full Bibliography >>

Areas of Expertise and/or Research

  • Autoimmunity
  • Microbiome
  • Neuroimmunology
  • Sex differences
  • Multiple sclerosis
  • Gene-by-environment interactions
  • Virology
  • Inflammatory bowel disease

Education

  • Postdoctoral training, University of Vermont (Laboratory of Dr. Cory Teuscher, Department of Medicine, Immunobiology Division, University of Vermont)
  • Ph.D. in Cell and Molecular Biology, University of Vermont (Laboratory of Dr. Markus Thali, Department of Microbiology and Molecular Genetics)
  • B.S. in Biology, University of Vermont (Undergraduate Research with Dr. Kathleen Trybus, Department of Molecular Physiology and Biophysics)

Contact

Phone:
  • 802-656-9024
Office Location:

Given C319A