Protein-protein interaction on the membrane of A. actinomycetemcomitans
I am a second year graduate student and I came from Jilin University, China. I decided to attend UVM for my graduate studies because the research being conducted here interested me and matched my undergraduate research experiences. Besides, the faculty and administrators here are really kind. Outside the laboratory, I enjoy photography and cooking.
Aggregatibacter actinomycetemcomitans is a Gram-negative, fastidious, microaerophilic bacterium involved in periodontal disease, a disease happening in oral cavity. Previous research showed that disruption of an outer membrane protein (morphogenesis protein C, MorC) leads to multiple phenotypic changes, including the alteration of the bacterial outer membrane from convoluted to flat, reduction of leukotoxin secretion and decrease of the ability of bacteria growth in detergents. These results indicate that MorC is interacting with other proteins on the membrane and the protein interaction is important for outer membrane function. I am interested in studying the protein interaction happening on the outer membrane of A. actinomycetemcomitans associated with MorC, the identity and function of the individual proteins involved in this protein-protein interaction.
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