I graduated from Trinity College in 2006 with a BS in biology and joined the CMB program in the fall of 2007. I decided to join the lab of Markus Thali to study the assembly and transmission process of HIV-1, with emphasis on host factors that can both negatively and positively influence viral replication. HIV-1 (like all viruses) relies heavily on host proteins and machinery to successfully replicate, therefore by identifying and understanding these interactions we can gain insight into basic cellular processes.
In the Thali lab, we use a variety of cellular and virological techniques in our studies. I have focused on using fluorescence imaging to investigate the specialized membrane domains formed by the HIV-1 Gag protein. In line with this, we now have access (here at the UVM microscopy imaging center) to a microscope setup capable of super-resolution imaging. I have begun to extend our studies to this non-diffraction limited imaging technique.
Roy NH, Chan J, Lambelé M, Thali M (2013) Clustering and mobility of HIV-1 Env at viral assembly sites predict its propensity to induce cell-cell fusion. J Virol 87(13): 7516-25.
Krementsov DN, Rassam P, Margeat E, Roy NH, Schneider-Schaulies J, Milhiet PE, Thali M (2010) HIV-1 assembly differentially alters dynamics and partitioning of tetraspanins and raft components. Traffic 11(11): 1401-14.
Krementsov DN, Weng J, Lambelé M, Roy NH, Thali M (2009) Tetraspanins regulate cell-to-cell transmission of HIV-1. Retrovirology 6: 64.
Weng J, Krementsov DN, Khurana S, Roy NH, Thali M (2009) Formation of syncytia is repressed by tetraspanins in human immunodeficiency virus type 1-producing cells. J Virol 83(15): 7467-74.
Office: 318 Stafford
Lab: 318 Stafford
- 12/10/2013 11:30 AM – 12:30 PM
Dr. Kelly Fimlaid
- 12/17/2013 11:30 AM – 12:30 PM
- 1/28/2014 11:30 AM – 12:30 PM
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