James Nolin

Redox control of inflammation in airway epithelial cells


Profile

I received my BS in Biology in 2006 from the University of Maine. After graduating, I spent the next two years living in Salzburg, Austria studying German and traveling (don’t ask about kangaroos). After coming back to reality, I worked in a lab at MMCRI in Scarborough, Maine for a year, and discovered a passion for research. I joined the CMB program in 2009, and am currently working in Dr. Yvonne Janssen-Heininger’s lab.

Recent Publications

Chapman DG, Tully JE, Nolin JD, Jansen-Heininger YM, Irvin CG (2014) Animal Models of Allergic Airways Disease: Where Are We and Where to Next? J Cell Biochem in press.

Nolin JD, Tully JE, Hoffman SM, Guala AS, van der Velden JL, Poynter ME, van der Vliet A, Anathy V, Janssen-Heininger YM (2014) The glutaredoxin/S-glutathionylation axis regulates interleukin-17A-induced proinflammatory responses in lung epithelial cells in association with S-glutathionylation of nuclear factor κB family proteins. Free Radic Biol Med 73: 143-53.

Hoffman SM, Tully JE, Nolin JD, Lahue KG, Goldman DH, Daphtary N, Aliyeva M, Irvin CG, Dixon AE, Poynter ME, Anathy V (2013) Endoplasmic reticulum stress mediates house dust mite-induced airway epithelial apoptosis and fibrosis. Respir Res 14: 141.

Tully JE, Hoffman SM, Lahue KG, Nolin JD, Anathy V, Lundblad LK, Daphtary N, Aliyeva M, Black KE, Dixon AE, Poynter ME, Irvin CG, Janssen-Heininger YM (2013) Epithelial NF-κB orchestrates house dust mite-induced airway inflammation, hyperresponsiveness, and fibrotic remodeling. J Immunol 191(12): 5811-21.

Janssen-Heininger YM, Nolin JD, Hoffman SM, van der Velden JL, Tully JE, Lahue KG, Abdalla ST, Chapman DG, Reynaert NL, van der Vliet A, Anathy V (2013) Emerging mechanisms of glutathione-dependent chemistry in biology and disease. J Cell Biochem 114(9): 1962-8.

Hoffman SM, Tully JE, Lahue KG, Anathy V, Nolin JD, Guala AS, van der Velden JL, Ho YS, Aliyeva M, Daphtary N, Lundblad LK, Irvin CG, Janssen-Heininger YM (2012) Genetic ablation of glutaredoxin-1 causes enhanced resolution of airways hyperresponsiveness and mucus metaplasia in mice with allergic airways disease. Am J Physiol Lung Cell Mol Physiol 303(6): L528-38.

Anathy V, Roberson E, Cunniff B, Nolin JD, Hoffman S, Spiess P, Guala AS, Lahue KG, Goldman D, Flemer S, van der Vliet A, Heintz NH, Budd RC, Tew KD, Janssen-Heininger YM (2012) Oxidative processing of latent Fas in the endoplasmic reticulum controls the strength of apoptosis. Mol Cell Biol 32(17): 3464-78.

View all Nolin publications here.