Dr. Irvin obtained his Ph.D. in Physiology from the University of Wisconsin in 1978, did a NIH postdoctoral fellowship at McGill University in Montreal from 1978-1980 and then moved to the National Jewish Center for Immunology and Respiratory Medicine in 1980. In 1998, he became head of the Vermont Lung Center. His translational research on animal models is extensively published as is his research into the mechanisms of asthma and lung disease.

Research Interests

Research focuses on asthma, pulmonary physiology and animal models of lung disease.

Selected Publications

Lee JJ, Dimina D, Macias MMP, Ochkur SI, McGarry MP, O’Neill KR, Protheroe C, Pero R, Nguyen T, Cormier SA, Lenkiewicz E, Colbert D, Rinaldi L, Ackerman SJ, Irvin CG, Lee NA. Mice Congenitally Deficient of Eosinophils Define a Link with Asthma Science 305:1773-1776, 2004.

Wagers SS, Norton RJ, Rinaldi LM, Bates JHT, Sobel BE, Irvin CG. Extravascular Fibrin, Plasminogen Activator, Plasminogen Activator Inhibitors, and Airway Hyperrresponsiveness. J Clin Invest 114:104-111, 2004

Diehl S. Krahl T, Rinaldi L, Norton R, Irvin CG, Rincon M. Inhibition of NFAT specifically in T cells prevents allergic pulmonary inflammation. J Immunol 172:3597-3603, 2004.

Wagers, Lundblad LKA, EkmanM, Irvin CG, Bates JHT. The Allergic Mouse Model of Asthma: Normal Smooth Muscle in an Abnormal Lung J. Appl. Physiol 96:2019-2027, 2004.

Poynter ME, Irvin CG, Janssen-Heininger YMW. A Prominent Role for Airway Epithelial NF-κB Activation on Lipopolysaccharide-Induced Airway Inflammation. J Immunology 170:6257-6265, 2003.