Wolfgang earned his M.D. from the Institute of Pharmacology and Toxicology, Technical University of Munich and his Ph.D. in organic chemistry from the University of Bremen, 1987. Wolfgang joined the UVM faculty in 1998 and is an Associate Professor in Pharmacology.

Research Interests

As a faculty member of the Department of Pharmacology at the University of Vermont, my research has continued to develop methods and tools that allow us to study the cGMP-PKG pathway in vitro and in vivo in unprecedented detail. Particularly our successes in developing fluorescence based cGMP-indicators and highly specific PKG inhibitors have allowed me to combine all aspects of my academic training.
Although my research interests are highly focused, my research projects have been and will continue to be stimulated and integrated through the use of a large variety of methods and techniques ranging from organic chemistry, biochemistry, molecular biology, cell biology, biophysics and pharmacology.

Selected Publications

Honda A, Sawyer CL, Cawley SM, and Dostmann, WRG. Cygnets: FRET-based intracellular cGMP imaging, Front. Bio. Sci., (2004)

Saywer CL, Honda A and Dostmann, WRG. Cygnets: intracellular cGMP-sensing in primary cells using fluorescent indicators Cell Biol. (2004)

Honda A, Saywer, CL, Cawley, SM and Dostmann, WRG. Cygnets: in vitro characterization of novel cGMP indicators and in vivo imaging of intracellular cGMP. Meth Mol Biol. (2004)

Foley KF, De Frutos S, Laskovski, KE and Dostmann, WR Cellular uptake mechanisms of membrane translocating cGMP-dependent protein kinase peptide inhibitors, Front. Biosci., (2004) in press

Dey N, Foley KF, Lincoln TM and Dostmann WRG. Inhibition of cGMP-dependent protein kinase-I attenuates contractile protein expression and contractile morphology in cultured rat aortic smooth muscle cells, J. Cardiovasc. Pharmacol, in press

CMB Lab Members