cGMP/PKG signaling in vascular smooth muscle; Pharmacology


Please see The Dostmann Lab Website for more information.

Recent Publications

Held KF, Dostmann WR (2013) Real-time monitoring the spatiotemporal dynamics of intracellular cGMP in vascular smooth muscle cells. Methods Mol Biol 1020: 131-45.

Moon TM, Osborne BW, Dostmann WR (2013) The switch helix: a putative combinatorial relay for interprotomer communication in cGMP-dependent protein kinase. Biochim Biophys Acta 1834(7): 1346-51.

Held KF, Dostmann WR (2012) Sub-Nanomolar Sensitivity of Nitric Oxide Mediated Regulation of cGMP and Vasomotor Reactivity in Vascular Smooth Muscle. Front Pharmacol 3: 130.

Miller CL, Cai Y, Oikawa M, Thomas T, Dostmann WR, Zaccolo M, Fujiwara K, Yan C (2011) Cyclic nucleotide phosphodiesterase 1A: a key regulator of cardiac fibroblast activation and extracellular matrix remodeling in the heart. Basic Res Cardiol 106(6): 1023-39.

Osborne BW, Wu J, McFarland CJ, Nickl CK, Sankaran B, Casteel DE, Woods VL Jr, Kornev AP, Taylor SS, Dostmann WR (2011) Crystal structure of cGMP-dependent protein kinase reveals novel site of interchain communication. Structure 19(9): 1317-27.

Caldwell GB, Howe AK, Nickl CK, Dostmann WR, Ballif BA, Deming PB (2012) Direct modulation of the protein kinase A catalytic subunit α by growth factor receptor tyrosine kinases. J Cell Biochem 113(1): 39-48.

Batchelor AM, Bartus K, Reynell C, Constantinou S, Halvey EJ, Held KF, Dostmann WR, Vernon J, Garthwaite J (2010) Exquisite sensitivity to subsecond, picomolar nitric oxide transients conferred on cells by guanylyl cyclase-coupled receptors. Proc Natl Acad Sci U S A 107(51): 22060-5.

View all Dostmann publications here.

Wolfgang Dostmann, M.D./Ph.D.

Dostmann, M.D./Ph.D.

Assistant Professor
Department of Pharmacology


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Lab: 330 HSRF

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