Vascular Smooth Muscle Signaling: Tumor Angiogenesis and Atherosclerosis

Integrating Cell Biology, Biochemistry and Molecular Biology
Regulation of hypoxia-inducible factor (HIF) by cytokines in ovarian cancer cells



Profile

Dr. Lounsbury received her B.S. in Biochemistry at Penn State in 1987 and her Ph.D. in Pharmacology at the University of Pennsylvania in 1993. She trained as a postdoc at the University of Vermont with Dr. Ian Macara from 1993-1997 and with Drs. Mark Nelson and Joseph Brayden from 1997-1998. She received her appointment to Assistant Professor of Pharmacology at UVM in 1998 and was promoted to Associate Professor with tenure in 2004.

Research Description

The overall goal of our research program is to define specific signal transduction patterns that relate to changes in gene expression in vascular smooth muscle. The intent of the research is to better understand signals generated under normal physiological versus pathological conditions to identify potential targets for both cancer and cardiovascular therapies. The research can be roughly divided into 3 project areas: 1) Calcium Regulated Gene Transcription in Vascular Smooth Muscle; 2) Signaling in Lung Epithelial Injury Proliferation and Fibrosis; 3) Regulation of Tumor Angiogenesis: Vascular Cell Responses to Hypoxia. The future directions of these projects include defining mechanisms of signaling pathways using molecular and cellular biology as well as exploring pharmacologic targets using animal models and clinical correlations.

Integrating Cell Biology, Biochemistry and Molecular Biology

Integrating Cell Biology, Biochemistry and Molecular Biology

Recent Publications

Wellman TL, Eckenstein M, Wong C, Rincon M, Ashikaga T, Mount SL, Francklyn CS, Lounsbury KM (2014) Threonyl-tRNA synthetase overexpression correlates with angiogenic markers and progression of human ovarian cancer. BMC Cancer 14: 620.

Shao Y, Wellman TL, Lounsbury KM, Zhao FQ (2014) Differential regulation of GLUT1 and GLUT8 expression by hypoxia in mammary epithelial cells. Am J Physiol Regul Integr Comp Physiol 307(3): R237-47.

Williams TF, Mirando AC, Wilkinson B, Francklyn CS, Lounsbury KM (2013) Secreted Threonyl-tRNA synthetase stimulates endothelial cell migration and angiogenesis. Sci Rep 3: 1317.

Cassavaugh JM, Hale SA, Wellman TL, Howe AK, Wong C, Lounsbury KM (2011) Negative regulation of HIF-1α by an FBW7-mediated degradation pathway during hypoxia. J Cell Biochem 112(12): 3882-90.

Olson N, Hristova M, Heintz NH, Lounsbury KM, van der Vliet A (2011) Activation of hypoxia-inducible factor-1 protects airway epithelium against oxidant-induced barrier dysfunction. Am J Physiol Lung Cell Mol Physiol 301(6): L993-L1002.

Cassavaugh J, Lounsbury KM (2011) Hypoxia-mediated biological control. J Cell Biochem 112(3): 735-44.

Buder-Hoffmann SA, Shukla A, Barrett TF, MacPherson MB, Lounsbury KM, Mossman BT (2009) A protein kinase Cdelta-dependent protein kinase D pathway modulates ERK1/2 and JNK1/2 phosphorylation and Bim-associated apoptosis by asbestos. Am J Pathol 174(2): 449-59.

View all Lounsbury publications here.

Selected Awards

AHA Scientist Development Award (1999-2002)

National Research Service Award (1994-1996)

NIH National Heart Lung Blood Institute (2001-2006)

Mary Kay Ash Ovarian Cancer Research Award (2003-2005)


Karen Lounsbury, Ph.D.

Karen
Lounsbury, Ph.D.

Associate Professor
Department of Pharmacology

 

802-656-1319
Office: 320 HSRF
Lab: 327 HSRF

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Upcoming Events

  • 9/16/2014 11:30 AM - 12:30 PM
    Davis Auditorium
    TBA
    Krithika Rao
  • 9/17/2014 9:30 AM - 10:30 AM
    Stafford Hall 101
    Genome variation and health/disease
    Dr. Kenneth Kidd
  • 9/23/2014 11:30 AM - 12:30 PM
    Davis Auditorium
    TBA
    Dr. Arsalan Syed

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