Molecular Mechanisms of Signal Transduction
After receiving a B.S. in Microbiology and a M.S. in Biochemistry I received a Ph.D. in Cell and Developmental Biology from Harvard University in 2001 where I studied core signaling pathways regulating cell survival in the laboratory of John Blenis. I then moved to Seattle where I studied signaling pathways regulating brain development for two years in the laboratory of Jonathan Cooper at the Fred Hutchinson Cancer Research Center. I then moved back to Boston where I completed my postdoctoral training at Harvard Medical School in the laboratory of Steven Gygi where I studied mass spectrometry and proteomics for three years. In 2006 I joined the Department of Biology at the University of Vermont.
Research in the Ballif lab is primarily focused on elucidating molecular mechanisms of signal transduction with two major emphases: (A) genetically-defined signaling pathways regulating mammalian brain development and (B) core signaling pathways regulating cell proliferation, growth and survival. In addition to biochemical and cell biological approaches, we employ mass spectrometry-based proteomics as a primary tool to simultaneously monitor hundreds to thousands of proteins, their modifications and their interactions with other proteins following acute signal administration or across developmental stages.
A second focus of our work involves developing and applying proteomic methodology to advance diverse lines of biological inquiry, some of which have had little to no interface with proteomics. This makes these projects both exciting and challenging. These collaborative projects range from the identification of novel human blood group antigens; to the identification of host proteins that interact with arenavirus proteins; to targeted proteomic characterizations of wasps, pitcher plant ecosystems, ants, fruit flies, unicellular ciliates and parasitic protozoa.
Klaus JP, Eisenhauer P, Russo J, Mason AB, Do D, King B, Taatjes D, Cornillez-Ty C, Boyson JE, Thali M, Zheng C, Liao L, Yates JR 3rd, Zhang B, Ballif BA, Botten JW (2013) The Intracellular Cargo Receptor ERGIC-53 Is Required for the Production of Infectious Arenavirus, Coronavirus, and Filovirus Particles. Cell Host Microbe 14(5): 522-34.
Aten TM, Redmond MM, Weaver SO, Love CC, Joy RM, Lapp AS, Rivera OD, Hinkle KL, Ballif BA (2013) Tyrosine phosphorylation of the orphan receptor ESDN/DCBLD2 serves as a scaffold for the signaling adaptor CrkL. FEBS Lett 587(15): 2313-8.
Ballif BA, Helias V, Peyrard T, Menanteau C, Saison C, Lucien N, Bourgouin S, Le Gall M, Cartron JP, Arnaud L (2013) Disruption of SMIM1 causes the Vel- blood type. EMBO Mol Med 5(5): 751-61.
Bior BK, Ballif BA (2013) Dab1 stabilizes its interaction with Cin85 by suppressing Cin85 phosphorylation at serine 587. FEBS Lett 587(1): 60-6.
Yano J, Rajendran A, Valentine MS, Saha M, Ballif BA, Van Houten JL (2013) Proteomic analysis of the cilia membrane of Paramecium tetraurelia. J Proteomics 78: 113-22.
Anjum R, Pae E, Blenis J, Ballif BA (2012) TPCK inhibits AGC kinases by direct activation loop adduction at phenylalanine-directed cysteine residues. FEBS Lett 586(19): 3471-6.
Saha M, Carriere A, Cheerathodi M, Zhang X, Lavoie G, Rush J, Roux PP, Ballif BA (2012) RSK phosphorylates SOS1 creating 14-3-3-docking sites and negatively regulating MAPK activation. Biochem J 447(1): 159-66.
Department of Biology
Office: 311 Marsh
Lab: 304 Marsh
- 12/10/2013 11:30 AM - 12:30 PM
Dr. Kelly Fimlaid
- 12/17/2013 11:30 AM - 12:30 PM
- 1/28/2014 11:30 AM - 12:30 PM
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