Neural control of cardiovascular function; stress, obesity and aging
M.D. Semmelweis University, Budapest, Hungary; 1993-1999
Ph.D., Physiology, Semmelweis University, Budapest, Hungary; 1999-2004
Postdoctoral Fellow, Dept. of Physiology and Pharmacology, Wake Forest University; 2001-2004
Supervisor: Prof. David W. Busija
Postdoctoral Fellow, Dept. of Pharmacology and Therapeutics, University of Florida 2004-2006
Supervisor: Prof. Nihal Tumer
Research Assistant Professor, Dept. of Pharmacology and Therapeutics, University of Florida; 2006-2011
Research Assistant Professor, Dept. of Physiology and Functional Genomics, University of Florida; 2011-2014
Assistant Professor, Dept. of Pharmacology, University of Vermont; 2014-
My research focuses on understanding how stress, obesity and aging affect neuroendocrine regulation of blood pressure with an aim to identify novel therapeutic targets for the treatment of hypertension and cardiovascular diseases.
The paraventricular nucleus of the hypothalamus (PVN) is a complex structure composed of several subgroups of neurons involved in maintaining homeostasis, regulating autonomic and endocrine responses to internal or external stressors and controlling food intake and energy expenditure. We are investigating these regulatory mechanisms within the PVN in order to better understand the ways stress, changes in diet, age and the combination of these factors lead to elevations in blood pressure. Ongoing projects are aimed to reveal the roles of neurotrophins such as brain-derived neurotrophic factor and nerve growth factor within the PVN and their involvement in acute stress responses, regulation of food intake and energy balance, neuroplasticity and enhancing antioxidant capacity.
We use whole animal and molecular techniques including radiotelemetric measurement of blood pressure in conscious animals, sympathetic nerve activity recording, stereotaxic brain injections of pharmacological agents and viral vectors for in vivo gene transfer, immunohistochemistry, fluorescent and confocal microscopy, Western blot, ELISA and quantitative real-time PCR.
Tümer N, Svetlov S, Whidden M, Kirichenko N, Prima V, Erdos B, Sherman A, Kobeissy F, Yezierski R, Scarpace PJ, Vierck C, Wang KK (2013) Overpressure blast-wave induced brain injury elevates oxidative stress in the hypothalamus and catecholamine biosynthesis in the rat adrenal medulla. Neurosci Lett 544: 62-7.
Daubert DL, McCowan M, Erdos B, Scheuer DA (2012) Nucleus of the solitary tract catecholaminergic neurons modulate the cardiovascular response to psychological stress in rats. J Physiol 590(Pt 19): 4881-95.
Erdos B, Kirichenko N, Whidden M, Basgut B, Woods M, Cudykier I, Tawil R, Scarpace PJ, Tumer N (2011) Effect of age on high-fat diet-induced hypertension. Am J Physiol Heart Circ Physiol 301(1): H164-72.
Whidden MA, Kirichenko N, Halici Z, Erdos B, Foster TC, Tümer N (2011) Lifelong caloric restriction prevents age-induced oxidative stress in the sympathoadrenal system of Fischer 344 x Brown Norway rats. Biochem Biophys Res Commun 408(3): 454-8.
Zhang Y, Rodrigues E, Gao YX, King M, Cheng KY, Erdös B, Tümer N, Carter C, Scarpace PJ (2010) Pro-opiomelanocortin gene transfer to the nucleus of the solitary track but not arcuate nucleus ameliorates chronic diet-induced obesity. Neuroscience 169(4): 1662-71.
Erdos B, Cudykier I, Woods M, Basgut B, Whidden M, Tawil R, Cardounel AJ, Tümer N (2010) Hypertensive effects of central angiotensin II infusion and restraint stress are reduced with age. J Hypertens 28(6): 1298-306.
Erdos B, Broxson CS, Cudykier I, Basgut B, Whidden M, Landa T, Scarpace PJ, Tümer N (2009) Effect of high-fat diet feeding on hypothalamic redox signaling and central blood pressure regulation. Hypertens Res 32(11): 983-8.
Department of Pharmacology
Office: E315 Given
Lab: E311 Given
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